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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 2011 Volume 39 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2011 Volume 39 Issue 4

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Article

Genetically engineered stem cells expressing cytosine deaminase and interferon-β migrate to human lung cancer cells and have potentially therapeutic anti-tumor effects

  • Authors:
    • Bo-Rim Yi
    • Si-Na O
    • Nam-Hee Kang
    • Kyung-A Hwang
    • Seung U. Kim
    • Eui-Bae Jeung
    • Yun-Bae Kim
    • Gang-Joon Heo
    • Kyung-Chul Choi

  • View Affiliations / Copyright

    Affiliations: College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 361-763, Republic of Korea, Laboratory of Veterinary Biochemistry and Immunology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 361-763, Republic of Korea
  • Pages: 833-839
    |
    Published online on: July 15, 2011
       https://doi.org/10.3892/ijo.2011.1126
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Abstract

Recent studies have shown that genetically engineered stem cells (GESTECs) produce suicide enzymes that convert non-toxic pro-drugs to toxic metabolites which selectively migrate toward tumor sites and reduce tumor growth. In the present study, we evaluated whether these GESTECs are capable of migrating to lung cancer cells and examined the potential therapeutic efficacy of gene-directed enzyme pro-drug therapy against lung cancer cells in vitro. A modified transwell migration assay was performed to determine the migratory capacity of GESTECs to lung cancer cells. GESTECs [i.e., HB1.F3.CD or HB1.F3.CD.interferon-β (IFN-β)] engineered to express a suicide gene, cytosine deaminase (CD), selectively migrated toward lung cancer cells. Treatment of a human non-small cell lung carcinoma cell line (A549, a lung carcinoma derived from human lung epithelial cells) with the pro-drug 5-fluorocytosine (5-FC) in the presence of HB1.F3.CD or HB1.F3.CD.IFN-β cells resulted in the inhibition of lung cancer cell growth. Based on the data presented herein, we suggest that GESTECs expressing CD may have a potent advantage for selective treatment of lung cancers. Furthermore, GESTECs expressing fusion genes (i.e., CD and IFN-β) may have a synergic antitumor effect on lung cancer cells.

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Copy and paste a formatted citation
Spandidos Publications style
Yi B, O S, Kang N, Hwang K, Kim SU, Jeung E, Kim Y, Heo G and Choi K: Genetically engineered stem cells expressing cytosine deaminase and interferon-β migrate to human lung cancer cells and have potentially therapeutic anti-tumor effects. Int J Oncol 39: 833-839, 2011.
APA
Yi, B., O, S., Kang, N., Hwang, K., Kim, S.U., Jeung, E. ... Choi, K. (2011). Genetically engineered stem cells expressing cytosine deaminase and interferon-β migrate to human lung cancer cells and have potentially therapeutic anti-tumor effects. International Journal of Oncology, 39, 833-839. https://doi.org/10.3892/ijo.2011.1126
MLA
Yi, B., O, S., Kang, N., Hwang, K., Kim, S. U., Jeung, E., Kim, Y., Heo, G., Choi, K."Genetically engineered stem cells expressing cytosine deaminase and interferon-β migrate to human lung cancer cells and have potentially therapeutic anti-tumor effects". International Journal of Oncology 39.4 (2011): 833-839.
Chicago
Yi, B., O, S., Kang, N., Hwang, K., Kim, S. U., Jeung, E., Kim, Y., Heo, G., Choi, K."Genetically engineered stem cells expressing cytosine deaminase and interferon-β migrate to human lung cancer cells and have potentially therapeutic anti-tumor effects". International Journal of Oncology 39, no. 4 (2011): 833-839. https://doi.org/10.3892/ijo.2011.1126
Copy and paste a formatted citation
x
Spandidos Publications style
Yi B, O S, Kang N, Hwang K, Kim SU, Jeung E, Kim Y, Heo G and Choi K: Genetically engineered stem cells expressing cytosine deaminase and interferon-β migrate to human lung cancer cells and have potentially therapeutic anti-tumor effects. Int J Oncol 39: 833-839, 2011.
APA
Yi, B., O, S., Kang, N., Hwang, K., Kim, S.U., Jeung, E. ... Choi, K. (2011). Genetically engineered stem cells expressing cytosine deaminase and interferon-β migrate to human lung cancer cells and have potentially therapeutic anti-tumor effects. International Journal of Oncology, 39, 833-839. https://doi.org/10.3892/ijo.2011.1126
MLA
Yi, B., O, S., Kang, N., Hwang, K., Kim, S. U., Jeung, E., Kim, Y., Heo, G., Choi, K."Genetically engineered stem cells expressing cytosine deaminase and interferon-β migrate to human lung cancer cells and have potentially therapeutic anti-tumor effects". International Journal of Oncology 39.4 (2011): 833-839.
Chicago
Yi, B., O, S., Kang, N., Hwang, K., Kim, S. U., Jeung, E., Kim, Y., Heo, G., Choi, K."Genetically engineered stem cells expressing cytosine deaminase and interferon-β migrate to human lung cancer cells and have potentially therapeutic anti-tumor effects". International Journal of Oncology 39, no. 4 (2011): 833-839. https://doi.org/10.3892/ijo.2011.1126
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