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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 2011 Volume 39 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article Open Access

Evaluation of effects caused by differentially spliced Ets-1 transcripts in fibroblasts

  • Authors:
    • Jens Claus Hahne
    • Tanja Fuchs
    • Alexandra Florin
    • Dylan Edwards
    • Albin Pourtier
    • Fabrice Soncin
    • Nicolas Wernert

  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, University of Würzburg, D-97080 Würzburg, Germany, Institute of Pathology, University of Bonn, P.O. Box 2120, D-53011 Bonn, Germany
  • Pages: 1073-1082
    |
    Published online on: August 9, 2011
       https://doi.org/10.3892/ijo.2011.1152
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Abstract

The transcription factor Ets-1 is known to be involved in a broad variety of cellular functions such as cell proliferation, migration, invasion, apoptosis and angiogenesis. In nearly all these reports, the full-length Ets-1 (p51) is commonly considered to be the active form and the role of the Ets-1ΔVII splice variant (p42) has not been addressed. Therefore, we studied the functional effects of p42 Ets-1 in comparison to p51 Ets-1 expression in a well-characterized mouse fibroblast cell line. Furthermore, the specific role of Ets-1 was evaluated using mouse fibroblasts with a reduced Ets-1 expression caused by RNAi and compared to fibroblasts with a binding inhibition of the whole ETS transcription factor family by stably overexpressing the ETS DNA binding domain as transdominant-negative mutant. Our results demonstrate that p42 Ets-1 has quite different functions and target genes compared to p51 Ets-1 (e.g. TIMP-4, MMP-3, MMP-9, MMP-13). In some cases (e.g. in cytokine expression) p42 Ets-1 is a functional transcription factor which acts in the same manner as a transdominant-negative approach.

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Copy and paste a formatted citation
Spandidos Publications style
Hahne JC, Fuchs T, Florin A, Edwards D, Pourtier A, Soncin F and Wernert N: Evaluation of effects caused by differentially spliced Ets-1 transcripts in fibroblasts. Int J Oncol 39: 1073-1082, 2011.
APA
Hahne, J.C., Fuchs, T., Florin, A., Edwards, D., Pourtier, A., Soncin, F., & Wernert, N. (2011). Evaluation of effects caused by differentially spliced Ets-1 transcripts in fibroblasts. International Journal of Oncology, 39, 1073-1082. https://doi.org/10.3892/ijo.2011.1152
MLA
Hahne, J. C., Fuchs, T., Florin, A., Edwards, D., Pourtier, A., Soncin, F., Wernert, N."Evaluation of effects caused by differentially spliced Ets-1 transcripts in fibroblasts". International Journal of Oncology 39.5 (2011): 1073-1082.
Chicago
Hahne, J. C., Fuchs, T., Florin, A., Edwards, D., Pourtier, A., Soncin, F., Wernert, N."Evaluation of effects caused by differentially spliced Ets-1 transcripts in fibroblasts". International Journal of Oncology 39, no. 5 (2011): 1073-1082. https://doi.org/10.3892/ijo.2011.1152
Copy and paste a formatted citation
x
Spandidos Publications style
Hahne JC, Fuchs T, Florin A, Edwards D, Pourtier A, Soncin F and Wernert N: Evaluation of effects caused by differentially spliced Ets-1 transcripts in fibroblasts. Int J Oncol 39: 1073-1082, 2011.
APA
Hahne, J.C., Fuchs, T., Florin, A., Edwards, D., Pourtier, A., Soncin, F., & Wernert, N. (2011). Evaluation of effects caused by differentially spliced Ets-1 transcripts in fibroblasts. International Journal of Oncology, 39, 1073-1082. https://doi.org/10.3892/ijo.2011.1152
MLA
Hahne, J. C., Fuchs, T., Florin, A., Edwards, D., Pourtier, A., Soncin, F., Wernert, N."Evaluation of effects caused by differentially spliced Ets-1 transcripts in fibroblasts". International Journal of Oncology 39.5 (2011): 1073-1082.
Chicago
Hahne, J. C., Fuchs, T., Florin, A., Edwards, D., Pourtier, A., Soncin, F., Wernert, N."Evaluation of effects caused by differentially spliced Ets-1 transcripts in fibroblasts". International Journal of Oncology 39, no. 5 (2011): 1073-1082. https://doi.org/10.3892/ijo.2011.1152
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