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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 2011 Volume 39 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2011 Volume 39 Issue 5

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Article

BART inhibits pancreatic cancer cell invasion by inhibiting ARL2-mediated RhoA inactivation

  • Authors:
    • Keisuke Taniuchi
    • Shinji Iwasaki
    • Toshiji Saibara
  • View Affiliations / Copyright

    Affiliations: Department of Gastro­enterology and Hepatology, Kochi University Medical School, Nankoku, Kochi 783-8505, Japan
  • Pages: 1243-1252
    |
    Published online on: August 10, 2011
       https://doi.org/10.3892/ijo.2011.1156
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Abstract

We report that BART plays a role in inhibiting cell invasion by regulating the activity of the Rho GTPase protein RhoA in pancreatic cancer cells. BART was originally identified as a binding partner of ARL2, a small G-protein implicated as a regulator of microtubule dynamics and folding. We show that BART interacts with GTP-bound ARL2 and is required for the binding of GTP-bound ARL2 with active forms of RhoA at leading edges in migrating cancer cells. GTP-bound ARL2 inactivates RhoA and BART prevents ARL2 from regulating RhoA activity. Thus, BART binds to and functions as an inhibitor of ARL2 at leading edges of migrating cells, thereby increasing the amount of active RhoA. Treatment with the Rho inhibitor C3 exoenzyme induces cell invasion by pancreatic cancer cells to the same level as that of cells in which BART is stably knocked down by RNA interference. GTP-bound ARL2 acts as a RhoA inhibitor by a mechanism that involves the induction of actin-cytoskeleton rearrangements. We show that BART decreases actin-cytoskeleton rearrangements by inhi­biting ARL2 function and by increasing the amount of active RhoA in pancreatic cancer cells. Our results imply that BART increases active RhoA by inhibiting ARL2 function, which in turn inhibits invasiveness of cancer cells.

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Copy and paste a formatted citation
Spandidos Publications style
Taniuchi K, Iwasaki S and Saibara T: BART inhibits pancreatic cancer cell invasion by inhibiting ARL2-mediated RhoA inactivation. Int J Oncol 39: 1243-1252, 2011.
APA
Taniuchi, K., Iwasaki, S., & Saibara, T. (2011). BART inhibits pancreatic cancer cell invasion by inhibiting ARL2-mediated RhoA inactivation. International Journal of Oncology, 39, 1243-1252. https://doi.org/10.3892/ijo.2011.1156
MLA
Taniuchi, K., Iwasaki, S., Saibara, T."BART inhibits pancreatic cancer cell invasion by inhibiting ARL2-mediated RhoA inactivation". International Journal of Oncology 39.5 (2011): 1243-1252.
Chicago
Taniuchi, K., Iwasaki, S., Saibara, T."BART inhibits pancreatic cancer cell invasion by inhibiting ARL2-mediated RhoA inactivation". International Journal of Oncology 39, no. 5 (2011): 1243-1252. https://doi.org/10.3892/ijo.2011.1156
Copy and paste a formatted citation
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Spandidos Publications style
Taniuchi K, Iwasaki S and Saibara T: BART inhibits pancreatic cancer cell invasion by inhibiting ARL2-mediated RhoA inactivation. Int J Oncol 39: 1243-1252, 2011.
APA
Taniuchi, K., Iwasaki, S., & Saibara, T. (2011). BART inhibits pancreatic cancer cell invasion by inhibiting ARL2-mediated RhoA inactivation. International Journal of Oncology, 39, 1243-1252. https://doi.org/10.3892/ijo.2011.1156
MLA
Taniuchi, K., Iwasaki, S., Saibara, T."BART inhibits pancreatic cancer cell invasion by inhibiting ARL2-mediated RhoA inactivation". International Journal of Oncology 39.5 (2011): 1243-1252.
Chicago
Taniuchi, K., Iwasaki, S., Saibara, T."BART inhibits pancreatic cancer cell invasion by inhibiting ARL2-mediated RhoA inactivation". International Journal of Oncology 39, no. 5 (2011): 1243-1252. https://doi.org/10.3892/ijo.2011.1156
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