Anti-tumor activity of fucoidan is mediated by nitric oxide released from macrophages

Takeda,Kaori; Tomimori,Koh; Kimura,Ryuichiro; Ishikawa,Chie; Nowling,Tamara  K.; Mori,Naoki

doi:10.3892/ijo.2011.1168

January 2012 Volume 40 Issue 1

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January 2012 Volume 40 Issue 1

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Article

Anti-tumor activity of fucoidan is mediated by nitric oxide released from macrophages

Authors:
- Kaori Takeda
- Koh Tomimori
- Ryuichiro Kimura
- Chie Ishikawa
- Tamara K. Nowling
- Naoki Mori
View Affiliations / Copyright

Affiliations: Department of Microbiology and Oncology, Graduate School of Medicine, University of the Ryukyus, Okinawa 903-0215, Japan, Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC 29425, USA
Pages: 251-260
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Published online on: August 18, 2011

https://doi.org/10.3892/ijo.2011.1168
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Abstract

Fucoidan, a sulfated polysaccharide, has significant cytotoxic activity against tumor cells; however, the mechanism(s) of this action remains poorly understood. The present study was designed to determine the in vitro and in vivo effects of fucoidan and their molecular mechanisms. Fucoidan from Cladosiphon okamuranus Tokida cultivated in Okinawa, Japan, delayed tumor growth in Sarcoma 180 (S-180)-bearing mice. However, it failed to inhibit S-180 cell growth in vitro. Activated macrophages are known to have anti-tumor effects. Murine RAW264.7 macrophages stimulated with fucoidan exerted cytotoxicity towards S-180 cells in vitro. This cytotoxicity was associated with nitric oxide (NO) production. Both cytocidal effect and NO production were significantly inhibited by L-NAME, an inhibitor of NO synthase (NOS). Furthermore, activation of nuclear factor-κB was a key step in the transcriptional activation of the inducible NOS gene. Taken together, our results indicate that the anti-tumor activity of fucoidan on S-180 cells is mediated through increased NO production by fucoidan-stimulated macrophages via nuclear factor-κB-dependent signaling pathway.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Anti-tumor activity of fucoidan is mediated by nitric oxide released from macrophages

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