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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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January 2012 Volume 40 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2012 Volume 40 Issue 1

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Article

Altered intestinal epithelium-associated lymphocyte repertoires and function in ApcMin/+ mice

  • Authors:
    • Lorraine Marsh
    • P. Louise Coletta
    • Mark A. Hull
    • Peter J. Selby
    • Simon R. Carding

  • View Affiliations / Copyright

    Affiliations: Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK, Leeds Institute of Molecular Medicine, Wellcome Trust Brenner Building, St. James's University Hospital, Leeds LS9 7TF, UK, Cancer Research UK Clinical Centre, St. James's University Hospital, Leeds LS9 7TF, UK, The Institute of Food Research and The University of East Anglia, Norwich Research Park, Norwich NR4 7UA, UK
  • Pages: 243-250
    |
    Published online on: August 29, 2011
       https://doi.org/10.3892/ijo.2011.1176
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Abstract

ApcMin/+ mice spontaneously develop multiple intestinal adenomas along the length of the small intestine and colon. Currently little is known about the role of the immune system in regulating intestinal tumorigenesis in these animals. This study characterised small intestinal intraepithelial lympho-­ cyte (IEL) populations in C56BL/6J ApcMin/+ mice and wild-type (Apc+/+) mice. We also determined the effect that T cells expressing either γδ or αβ encoded T cell receptors (TcR) exert on intestinal tumorigenesis. ApcMin/+ mice had significantly lower numbers of CD3+ IELs compared with Apc+/+ littermates and displayed reduced cytotoxicity against tumour target cells. Further analysis of IEL cytotoxicity revealed differences in the cytotoxic pathways utilised by IELs in ApcMin/+ and Apc+/+ mice with ApcMin/+ IELs displaying an absence of perforin/granzyme-mediated killing and increased levels of Fas-FasL-mediated cytotoxicity compared with wild-type IELs. Analysis of ApcMin/+ mice crossed with αβ T-cell deficient (TcRβ-/-) or γδ T-cell deficient (TcRδ-/-) mice on the same genetic background revealed decreased tumour multiplicity in the absence of both αβ and γδ T-cells. This study demonstrates that altered T-cell subsets play important roles in promoting tumorigenesis in ApcMin/+ mice and forms the basis for future mechanistic studies.

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Copy and paste a formatted citation
Spandidos Publications style
Marsh L, Coletta PL, Hull MA, Selby PJ and Carding SR: Altered intestinal epithelium-associated lymphocyte repertoires and function in ApcMin/+ mice. Int J Oncol 40: 243-250, 2012.
APA
Marsh, L., Coletta, P.L., Hull, M.A., Selby, P.J., & Carding, S.R. (2012). Altered intestinal epithelium-associated lymphocyte repertoires and function in ApcMin/+ mice. International Journal of Oncology, 40, 243-250. https://doi.org/10.3892/ijo.2011.1176
MLA
Marsh, L., Coletta, P. L., Hull, M. A., Selby, P. J., Carding, S. R."Altered intestinal epithelium-associated lymphocyte repertoires and function in ApcMin/+ mice". International Journal of Oncology 40.1 (2012): 243-250.
Chicago
Marsh, L., Coletta, P. L., Hull, M. A., Selby, P. J., Carding, S. R."Altered intestinal epithelium-associated lymphocyte repertoires and function in ApcMin/+ mice". International Journal of Oncology 40, no. 1 (2012): 243-250. https://doi.org/10.3892/ijo.2011.1176
Copy and paste a formatted citation
x
Spandidos Publications style
Marsh L, Coletta PL, Hull MA, Selby PJ and Carding SR: Altered intestinal epithelium-associated lymphocyte repertoires and function in ApcMin/+ mice. Int J Oncol 40: 243-250, 2012.
APA
Marsh, L., Coletta, P.L., Hull, M.A., Selby, P.J., & Carding, S.R. (2012). Altered intestinal epithelium-associated lymphocyte repertoires and function in ApcMin/+ mice. International Journal of Oncology, 40, 243-250. https://doi.org/10.3892/ijo.2011.1176
MLA
Marsh, L., Coletta, P. L., Hull, M. A., Selby, P. J., Carding, S. R."Altered intestinal epithelium-associated lymphocyte repertoires and function in ApcMin/+ mice". International Journal of Oncology 40.1 (2012): 243-250.
Chicago
Marsh, L., Coletta, P. L., Hull, M. A., Selby, P. J., Carding, S. R."Altered intestinal epithelium-associated lymphocyte repertoires and function in ApcMin/+ mice". International Journal of Oncology 40, no. 1 (2012): 243-250. https://doi.org/10.3892/ijo.2011.1176
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