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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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January 2012 Volume 40 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2012 Volume 40 Issue 1

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Article

Increased P-glycoprotein expression in mitochondria is related to acquired multidrug resistance in human hepatoma cells depleted of mitochondrial DNA

  • Authors:
    • Xianlong Ling
    • Yuqi He
    • Guoqiao Zhang
    • Yuan Zhou
    • Bin Yan

  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, P.R. China
  • Pages: 109-118
    |
    Published online on: August 31, 2011
       https://doi.org/10.3892/ijo.2011.1181
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Abstract

Mitochondrial DNA-depleted ρ0 cells are resistant to apoptosis, but the mechanism remains unclear. A human hepatoma cell line (SK-Hep1) depleted of mtDNA (ρ0SK-Hep1) was induced by ethidium bromide treatment. The ρ0SK-Hep1 cells were resistant to both doxorubicin- and cisplatin-induced apoptosis, while cybrids (SK-Hep1Cyb) prepared by fusing ρ0SK-Hep1 cells with platelets showed restored susceptibility to both drugs. We observed P-glycoprotein and MRP1 were both overexpressed in ρ0 cells, and more P-glycoproteins were localized in the mitochondria and were functionally active. ρ0 cells showed resistance to chemotherapeutic drug-induced apoptosis. The increased expression and localization of P-glycoproteins in the mitochondria of ρ0 cells may facilitate the exclusion of chemotherapeutic drugs from the mitochondria to the cytosol.

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Copy and paste a formatted citation
Spandidos Publications style
Ling X, He Y, Zhang G, Zhou Y and Yan B: Increased P-glycoprotein expression in mitochondria is related to acquired multidrug resistance in human hepatoma cells depleted of mitochondrial DNA. Int J Oncol 40: 109-118, 2012.
APA
Ling, X., He, Y., Zhang, G., Zhou, Y., & Yan, B. (2012). Increased P-glycoprotein expression in mitochondria is related to acquired multidrug resistance in human hepatoma cells depleted of mitochondrial DNA. International Journal of Oncology, 40, 109-118. https://doi.org/10.3892/ijo.2011.1181
MLA
Ling, X., He, Y., Zhang, G., Zhou, Y., Yan, B."Increased P-glycoprotein expression in mitochondria is related to acquired multidrug resistance in human hepatoma cells depleted of mitochondrial DNA". International Journal of Oncology 40.1 (2012): 109-118.
Chicago
Ling, X., He, Y., Zhang, G., Zhou, Y., Yan, B."Increased P-glycoprotein expression in mitochondria is related to acquired multidrug resistance in human hepatoma cells depleted of mitochondrial DNA". International Journal of Oncology 40, no. 1 (2012): 109-118. https://doi.org/10.3892/ijo.2011.1181
Copy and paste a formatted citation
x
Spandidos Publications style
Ling X, He Y, Zhang G, Zhou Y and Yan B: Increased P-glycoprotein expression in mitochondria is related to acquired multidrug resistance in human hepatoma cells depleted of mitochondrial DNA. Int J Oncol 40: 109-118, 2012.
APA
Ling, X., He, Y., Zhang, G., Zhou, Y., & Yan, B. (2012). Increased P-glycoprotein expression in mitochondria is related to acquired multidrug resistance in human hepatoma cells depleted of mitochondrial DNA. International Journal of Oncology, 40, 109-118. https://doi.org/10.3892/ijo.2011.1181
MLA
Ling, X., He, Y., Zhang, G., Zhou, Y., Yan, B."Increased P-glycoprotein expression in mitochondria is related to acquired multidrug resistance in human hepatoma cells depleted of mitochondrial DNA". International Journal of Oncology 40.1 (2012): 109-118.
Chicago
Ling, X., He, Y., Zhang, G., Zhou, Y., Yan, B."Increased P-glycoprotein expression in mitochondria is related to acquired multidrug resistance in human hepatoma cells depleted of mitochondrial DNA". International Journal of Oncology 40, no. 1 (2012): 109-118. https://doi.org/10.3892/ijo.2011.1181
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