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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May 2011 Volume 38 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2011 Volume 38 Issue 5

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Article

Auto-stimulatory action of secreted caveolin-1 on the proliferation of Ewing's sarcoma cells

  • Authors:
    • Aniruddha Sengupta
    • Silvia Mateo-Lozano
    • Oscar M. Tirado
    • Vicente Notario

  • View Affiliations / Copyright

    Affiliations: Department of Radiation Medicine, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA, Department of Radiation Medicine, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA
  • Pages: 1259-1265
    |
    Published online on: March 3, 2011
       https://doi.org/10.3892/ijo.2011.963
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Abstract

Caveolin-1 (CAV1) is highly expressed in Ewing's sarcoma (EWS). We previously showed that increased cellular CAV1 is associated with the regulation of the tumorigenicity, drug resistance and metastatic ability of EWS cells. Because several studies reported that melanoma and prostate cancer cells, which express relatively high CAV1 levels, secrete CAV1, and that secreted CAV1 is associated with tumor progression, our study explored the possibility that EWS cells also secreted CAV1 and that secreted CAV1 may contribute to EWS pathobiology. Results from experiments involving the ectopic expression of a Myc-tagged CAV1 protein in EWS cells as well as the supplementation of culture media with purified CAV1 protein followed by its intracellular localization using immunofluorescence demonstrated that EWS cells secrete CAV1, that they are able to take up the secreted protein, and that extracellular CAV1 enhances EWS cell proliferation. These findings strongly support the notion that secreted CAV1 may also contribute to the malignant properties of EWS.

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Copy and paste a formatted citation
Spandidos Publications style
Sengupta A, Mateo-Lozano S, Tirado OM and Notario V: Auto-stimulatory action of secreted caveolin-1 on the proliferation of Ewing's sarcoma cells. Int J Oncol 38: 1259-1265, 2011.
APA
Sengupta, A., Mateo-Lozano, S., Tirado, O.M., & Notario, V. (2011). Auto-stimulatory action of secreted caveolin-1 on the proliferation of Ewing's sarcoma cells. International Journal of Oncology, 38, 1259-1265. https://doi.org/10.3892/ijo.2011.963
MLA
Sengupta, A., Mateo-Lozano, S., Tirado, O. M., Notario, V."Auto-stimulatory action of secreted caveolin-1 on the proliferation of Ewing's sarcoma cells". International Journal of Oncology 38.5 (2011): 1259-1265.
Chicago
Sengupta, A., Mateo-Lozano, S., Tirado, O. M., Notario, V."Auto-stimulatory action of secreted caveolin-1 on the proliferation of Ewing's sarcoma cells". International Journal of Oncology 38, no. 5 (2011): 1259-1265. https://doi.org/10.3892/ijo.2011.963
Copy and paste a formatted citation
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Spandidos Publications style
Sengupta A, Mateo-Lozano S, Tirado OM and Notario V: Auto-stimulatory action of secreted caveolin-1 on the proliferation of Ewing's sarcoma cells. Int J Oncol 38: 1259-1265, 2011.
APA
Sengupta, A., Mateo-Lozano, S., Tirado, O.M., & Notario, V. (2011). Auto-stimulatory action of secreted caveolin-1 on the proliferation of Ewing's sarcoma cells. International Journal of Oncology, 38, 1259-1265. https://doi.org/10.3892/ijo.2011.963
MLA
Sengupta, A., Mateo-Lozano, S., Tirado, O. M., Notario, V."Auto-stimulatory action of secreted caveolin-1 on the proliferation of Ewing's sarcoma cells". International Journal of Oncology 38.5 (2011): 1259-1265.
Chicago
Sengupta, A., Mateo-Lozano, S., Tirado, O. M., Notario, V."Auto-stimulatory action of secreted caveolin-1 on the proliferation of Ewing's sarcoma cells". International Journal of Oncology 38, no. 5 (2011): 1259-1265. https://doi.org/10.3892/ijo.2011.963
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