MicroRNA miR-125b is a prognostic marker in human colorectal cancer

Nishida,Naohiro; Yokobori,Takehiko; Mimori,Koshi; Sudo,Tomoya; Tanaka,Fumiaki; Shibata,Kohei; Ishii,Hideshi; Doki,Yuichiro; Kuwano,Hiroyuki; Mori,Masaki

doi:10.3892/ijo.2011.969

May 2011 Volume 38 Issue 5

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May 2011 Volume 38 Issue 5

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Article

MicroRNA miR-125b is a prognostic marker in human colorectal cancer

Authors:
- Naohiro Nishida
- Takehiko Yokobori
- Koshi Mimori
- Tomoya Sudo
- Fumiaki Tanaka
- Kohei Shibata
- Hideshi Ishii
- Yuichiro Doki
- Hiroyuki Kuwano
- Masaki Mori
View Affiliations / Copyright

Affiliations: Department of Surgery and Molecular Oncology, Medical Institute of Bioregulation, Kyushu University, 4546 Tsurumibaru, Beppu, Oita 874-0838, Japan, Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita City, Osaka 565-0871, Japan
Pages: 1437-1443
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Published online on: March 10, 2011

https://doi.org/10.3892/ijo.2011.969
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Abstract

MicroRNAs (miRNAs) are small, non-coding RNAs that can function as oncogenes or tumor suppressors in human cancer. Recent reports have highlighted the oncogenic aspects of microRNA miR-125b. However, the clinical significance of miR-125b in gastrointestinal cancers has not been sufficiently investigated. To this end, we analyzed miR-125b expression in colorectal cancer cases. Quantitative RT-PCR was used to evaluate miR-125b expression in 89 colorectal cancer cases to determine the clinicopathological significance of miR-125b expression. The high miR-125b expression group showed a greater incidence of advanced tumor size and tumor invasion compared to the low miR-125b expression group (P<0.05). In addition, the high miR-125b expression group had a significantly poorer prognosis compared to the low expression group (P<0.05). Multivariate analysis indicated that high miR-125b expression was an independent prognostic factor for survival. Our analysis of miR-125b focused on the miR-125b/p53 pathway. In vitro assays revealed that overexpression of miR-125b repressed the endogenous level of p53 protein in human colorectal cancer cells. These data show that miR-125b is directly involved in cancer progression and is associated with poor prognosis in human colorectal cancer. Our findings suggest that miR-125b could be an important prognostic indicator for colorectal cancer patients.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

MicroRNA miR-125b is a prognostic marker in human colorectal cancer

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Abstract

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