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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May 2011 Volume 38 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2011 Volume 38 Issue 5

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Review

microRNA-34 family and treatment of cancers with mutant or wild-type p53 (Review)

  • Authors:
    • May Y.W. Wong
    • Yan Yu
    • William R. Walsh
    • Jia-Lin Yang

  • View Affiliations / Copyright

    Affiliations: Surgical and Orthopaedics Research Laboratories, Prince of Wales Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia, Oncology Research Centre, Level 2 Clinical Sciences Building, Prince of Wales Hospital, Randwick, Sydney, NSW 2031, Australia
  • Pages: 1189-1195
    |
    Published online on: March 10, 2011
       https://doi.org/10.3892/ijo.2011.970
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Abstract

In the last decade, microRNAs (miRNAs; small noncoding RNA molecules) as post-transcriptional regulators have been a hotspot in research for their involvement in biological processes and tumour development. However, there have been few reviews focusing on a single miRNA family. The dysregulation of miRNAs appears to play a crucial role in cancer pathogenesis where they exert their effect as oncogenes or as tumour suppressors. This review summarises current studies on the dysregulation of the microRNA-34 (miR-34) family in different types of cancers and its role in the p53 network. The structure of the miR-34 family members includes p53-binding sites reflecting their function as tumour suppressors downstream of the p53 pathway. miR-34 dysregulation occurs in cancers, including several epithelial cancers, melanomas, neuroblastomas, leukemias and sarcomas, in the presence or absence of the p53 mutation. For these cancers, functional restoration of miR-34 is a useful novel therapy. As evidenced from preclinical and clinical studies, the miR-34 family plays an important role in the treatment of miR-34-dysregulated cancers with mutant or wild-type p53. This review will have a potential impact in the clinical treatment of p53-mutant and/or miR-34-dysregulated cancers using a miR-34 restoration approach.

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Copy and paste a formatted citation
Spandidos Publications style
Wong MY, Yu Y, Walsh WR and Yang J: microRNA-34 family and treatment of cancers with mutant or wild-type p53 (Review). Int J Oncol 38: 1189-1195, 2011.
APA
Wong, M.Y., Yu, Y., Walsh, W.R., & Yang, J. (2011). microRNA-34 family and treatment of cancers with mutant or wild-type p53 (Review). International Journal of Oncology, 38, 1189-1195. https://doi.org/10.3892/ijo.2011.970
MLA
Wong, M. Y., Yu, Y., Walsh, W. R., Yang, J."microRNA-34 family and treatment of cancers with mutant or wild-type p53 (Review)". International Journal of Oncology 38.5 (2011): 1189-1195.
Chicago
Wong, M. Y., Yu, Y., Walsh, W. R., Yang, J."microRNA-34 family and treatment of cancers with mutant or wild-type p53 (Review)". International Journal of Oncology 38, no. 5 (2011): 1189-1195. https://doi.org/10.3892/ijo.2011.970
Copy and paste a formatted citation
x
Spandidos Publications style
Wong MY, Yu Y, Walsh WR and Yang J: microRNA-34 family and treatment of cancers with mutant or wild-type p53 (Review). Int J Oncol 38: 1189-1195, 2011.
APA
Wong, M.Y., Yu, Y., Walsh, W.R., & Yang, J. (2011). microRNA-34 family and treatment of cancers with mutant or wild-type p53 (Review). International Journal of Oncology, 38, 1189-1195. https://doi.org/10.3892/ijo.2011.970
MLA
Wong, M. Y., Yu, Y., Walsh, W. R., Yang, J."microRNA-34 family and treatment of cancers with mutant or wild-type p53 (Review)". International Journal of Oncology 38.5 (2011): 1189-1195.
Chicago
Wong, M. Y., Yu, Y., Walsh, W. R., Yang, J."microRNA-34 family and treatment of cancers with mutant or wild-type p53 (Review)". International Journal of Oncology 38, no. 5 (2011): 1189-1195. https://doi.org/10.3892/ijo.2011.970
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