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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 2011 Volume 38 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2011 Volume 38 Issue 6

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Article

A demethylating agent enhances chemosensitivity to vinblastine in a xenograft model of renal cell carcinoma

  • Authors:
    • Hiroki Iwata
    • Hiromi Sato
    • Rina Suzuki
    • Ryota Yamada
    • Saki Ichinomiya
    • Midori  Yanagihara
    • Hiroyuki Okabe
    • Yuko Sekine
    • Tomohiro Yano
    • Koichi Ueno
  • View Affiliations / Copyright

    Affiliations: Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan
  • Pages: 1653-1661
    |
    Published online on: April 6, 2011
       https://doi.org/10.3892/ijo.2011.999
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Abstract

Renal cell carcinoma (RCC) is resistant to chemo­therapy partly due to the overexpression of the P-glycoprotein. Several tumor suppressor genes have been reported to be silenced by hypermethylation of the promoter region in RCC. We recently reported that the in vitro cytotoxicity of vinblastine (VBL) was enhanced by pre-treatment with the demethylating agent, 5-aza-2’-deoxycytidine (Aza), in the RCC cell line, Caki-1. In this study, we investigated the combined effect of Aza and VBL in a Caki-1 xenograft model and in other RCC cell lines in vitro. In the xenograft model, tumor volume and weight were significantly suppressed in the co-treatment group, compared to the control, and the expressions of P-glycoprotein, Bcl-2 and cyclin B1 were reduced. Thus, this combined effect could be mediated by the accumulation of intracellular VBL and the enhancement of apoptosis and cell cycle arrest. More­over, the cytotoxicity of VBL was enhanced in vitro in three RCC cell lines by Aza treatment. These findings suggest that the combination treatment with Aza and VBL is effective against RCC.

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Copy and paste a formatted citation
Spandidos Publications style
Iwata H, Sato H, Suzuki R, Yamada R, Ichinomiya S, Yanagihara M, Okabe H, Sekine Y, Yano T, Ueno K, Ueno K, et al: A demethylating agent enhances chemosensitivity to vinblastine in a xenograft model of renal cell carcinoma. Int J Oncol 38: 1653-1661, 2011.
APA
Iwata, H., Sato, H., Suzuki, R., Yamada, R., Ichinomiya, S., Yanagihara, M. ... Ueno, K. (2011). A demethylating agent enhances chemosensitivity to vinblastine in a xenograft model of renal cell carcinoma. International Journal of Oncology, 38, 1653-1661. https://doi.org/10.3892/ijo.2011.999
MLA
Iwata, H., Sato, H., Suzuki, R., Yamada, R., Ichinomiya, S., Yanagihara, M., Okabe, H., Sekine, Y., Yano, T., Ueno, K."A demethylating agent enhances chemosensitivity to vinblastine in a xenograft model of renal cell carcinoma". International Journal of Oncology 38.6 (2011): 1653-1661.
Chicago
Iwata, H., Sato, H., Suzuki, R., Yamada, R., Ichinomiya, S., Yanagihara, M., Okabe, H., Sekine, Y., Yano, T., Ueno, K."A demethylating agent enhances chemosensitivity to vinblastine in a xenograft model of renal cell carcinoma". International Journal of Oncology 38, no. 6 (2011): 1653-1661. https://doi.org/10.3892/ijo.2011.999
Copy and paste a formatted citation
x
Spandidos Publications style
Iwata H, Sato H, Suzuki R, Yamada R, Ichinomiya S, Yanagihara M, Okabe H, Sekine Y, Yano T, Ueno K, Ueno K, et al: A demethylating agent enhances chemosensitivity to vinblastine in a xenograft model of renal cell carcinoma. Int J Oncol 38: 1653-1661, 2011.
APA
Iwata, H., Sato, H., Suzuki, R., Yamada, R., Ichinomiya, S., Yanagihara, M. ... Ueno, K. (2011). A demethylating agent enhances chemosensitivity to vinblastine in a xenograft model of renal cell carcinoma. International Journal of Oncology, 38, 1653-1661. https://doi.org/10.3892/ijo.2011.999
MLA
Iwata, H., Sato, H., Suzuki, R., Yamada, R., Ichinomiya, S., Yanagihara, M., Okabe, H., Sekine, Y., Yano, T., Ueno, K."A demethylating agent enhances chemosensitivity to vinblastine in a xenograft model of renal cell carcinoma". International Journal of Oncology 38.6 (2011): 1653-1661.
Chicago
Iwata, H., Sato, H., Suzuki, R., Yamada, R., Ichinomiya, S., Yanagihara, M., Okabe, H., Sekine, Y., Yano, T., Ueno, K."A demethylating agent enhances chemosensitivity to vinblastine in a xenograft model of renal cell carcinoma". International Journal of Oncology 38, no. 6 (2011): 1653-1661. https://doi.org/10.3892/ijo.2011.999
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