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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 2012 Volume 41 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2012 Volume 41 Issue 1

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Article

CYP1A1 is a target of miR-892a-mediated post-transcriptional repression

  • Authors:
    • Yeong Min Choi
    • Sungkwan An
    • Eun-Mee Lee
    • Karam Kim
    • Sung Jin Choi
    • Ju Sub Kim
    • Hyun Hee Jang
    • In-Sook An
    • Seunghee Bae

  • View Affiliations / Copyright

    Affiliations: Functional Genoproteome Research Centre and LIFEnGENE Inc., Seoul 143-701, Republic of Korea, Department of Cosmetology, Sangji Youngseo College, Wonju-si, Gwangwon‑do 220‑713, Republic of Korea, School of Cosmetology, Kyungbok University, Pocheon-si, Gyeonggi-do 487-717, Republic of Korea
  • Pages: 331-336
    |
    Published online on: March 28, 2012
       https://doi.org/10.3892/ijo.2012.1418
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Abstract

Cytochrome P450 1A1 (CYP1A1) is a member of the cytochrome p450 enzyme family, which is involved in the metabolisms of carcinogenic metabolites, such as benzo(a)pyrene. In this study, we identified miR-892a as a negative regulator of CYP1A1 expression. Luciferase assays revealed a sequence in the 3'-untranslated region of CYP1A1 that displayed a perfect match with miR-892a, and revealed that this sequence was a specific miR-892a target site. The overexpression of miR‑892a inhibited the expression of the CYP1A1 protein, and the miR‑892a antagonist increased CYP1A1 expression. Of note, benzo(a)pyrene, a major inducer of CYP1A1 transcription, decreased the expression of miR-892a. Moreover, the miR-892a-induced CYP1A1 repression inhibited the benzo(a)pyrene-mediated decrease in cell viability. These data provide insight into the CYP1A1 regulatory network.

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Copy and paste a formatted citation
Spandidos Publications style
Choi YM, An S, Lee E, Kim K, Choi SJ, Kim JS, Jang HH, An I and Bae S: CYP1A1 is a target of miR-892a-mediated post-transcriptional repression. Int J Oncol 41: 331-336, 2012.
APA
Choi, Y.M., An, S., Lee, E., Kim, K., Choi, S.J., Kim, J.S. ... Bae, S. (2012). CYP1A1 is a target of miR-892a-mediated post-transcriptional repression. International Journal of Oncology, 41, 331-336. https://doi.org/10.3892/ijo.2012.1418
MLA
Choi, Y. M., An, S., Lee, E., Kim, K., Choi, S. J., Kim, J. S., Jang, H. H., An, I., Bae, S."CYP1A1 is a target of miR-892a-mediated post-transcriptional repression". International Journal of Oncology 41.1 (2012): 331-336.
Chicago
Choi, Y. M., An, S., Lee, E., Kim, K., Choi, S. J., Kim, J. S., Jang, H. H., An, I., Bae, S."CYP1A1 is a target of miR-892a-mediated post-transcriptional repression". International Journal of Oncology 41, no. 1 (2012): 331-336. https://doi.org/10.3892/ijo.2012.1418
Copy and paste a formatted citation
x
Spandidos Publications style
Choi YM, An S, Lee E, Kim K, Choi SJ, Kim JS, Jang HH, An I and Bae S: CYP1A1 is a target of miR-892a-mediated post-transcriptional repression. Int J Oncol 41: 331-336, 2012.
APA
Choi, Y.M., An, S., Lee, E., Kim, K., Choi, S.J., Kim, J.S. ... Bae, S. (2012). CYP1A1 is a target of miR-892a-mediated post-transcriptional repression. International Journal of Oncology, 41, 331-336. https://doi.org/10.3892/ijo.2012.1418
MLA
Choi, Y. M., An, S., Lee, E., Kim, K., Choi, S. J., Kim, J. S., Jang, H. H., An, I., Bae, S."CYP1A1 is a target of miR-892a-mediated post-transcriptional repression". International Journal of Oncology 41.1 (2012): 331-336.
Chicago
Choi, Y. M., An, S., Lee, E., Kim, K., Choi, S. J., Kim, J. S., Jang, H. H., An, I., Bae, S."CYP1A1 is a target of miR-892a-mediated post-transcriptional repression". International Journal of Oncology 41, no. 1 (2012): 331-336. https://doi.org/10.3892/ijo.2012.1418
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