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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 2012 Volume 41 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

PSK induces apoptosis through the inhibition of activated STAT3 in human esophageal carcinoma cells

  • Authors:
    • Seiji Umehara
    • Hitoshi Fujiwara
    • Atsushi Shiozaki
    • Momoko Todo
    • Akinobu Furutani
    • Masayuki Yoneda
    • Atsushi Ikai
    • Hiroyuki Tada
    • Shuhei Komatsu
    • Daisuke Ichikawa
    • Kazuma Okamoto
    • Toshiya Ochiai
    • Yukihito Kokuba
    • Eigo Otsuji

  • View Affiliations / Copyright

    Affiliations: Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
  • Pages: 61-66
    |
    Published online on: April 30, 2012
       https://doi.org/10.3892/ijo.2012.1454
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Abstract

PSK, a protein-bound polysaccharide, is widely used in Japan as an immunopotentiating biological response modifier for cancer patients. PSK exerts antitumor activities through stimulation of the host's immune response; however, few studies have addressed the direct actions of PSK on tumor cells. Recently, it has been found that STAT3 is aberrantly activated in various types of malignancies, and plays a crucial role in tumor cell proliferation and survival. In the present study, STAT3 was constitutively activated in KYSE170 and TE13 esophageal carcinoma cells, and PSK inhibited proliferation and induced apoptosis in these cells in a dose-dependent manner. Based on these findings, the relationship between STAT3 and apoptosis in these cells was investigated. Results showed that PSK inhibited the expression of activated STAT3 and stimulated the expression of pro-apoptotic Bax in a dose-dependent manner, without affecting the expression of anti-apoptotic Bcl-xL and Mcl-1. These results indicate that PSK may induce apoptosis in esophageal carcinoma cells by inhibiting the expression of activated STAT3.

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Copy and paste a formatted citation
Spandidos Publications style
Umehara S, Fujiwara H, Shiozaki A, Todo M, Furutani A, Yoneda M, Ikai A, Tada H, Komatsu S, Ichikawa D, Ichikawa D, et al: PSK induces apoptosis through the inhibition of activated STAT3 in human esophageal carcinoma cells. Int J Oncol 41: 61-66, 2012.
APA
Umehara, S., Fujiwara, H., Shiozaki, A., Todo, M., Furutani, A., Yoneda, M. ... Otsuji, E. (2012). PSK induces apoptosis through the inhibition of activated STAT3 in human esophageal carcinoma cells. International Journal of Oncology, 41, 61-66. https://doi.org/10.3892/ijo.2012.1454
MLA
Umehara, S., Fujiwara, H., Shiozaki, A., Todo, M., Furutani, A., Yoneda, M., Ikai, A., Tada, H., Komatsu, S., Ichikawa, D., Okamoto, K., Ochiai, T., Kokuba, Y., Otsuji, E."PSK induces apoptosis through the inhibition of activated STAT3 in human esophageal carcinoma cells". International Journal of Oncology 41.1 (2012): 61-66.
Chicago
Umehara, S., Fujiwara, H., Shiozaki, A., Todo, M., Furutani, A., Yoneda, M., Ikai, A., Tada, H., Komatsu, S., Ichikawa, D., Okamoto, K., Ochiai, T., Kokuba, Y., Otsuji, E."PSK induces apoptosis through the inhibition of activated STAT3 in human esophageal carcinoma cells". International Journal of Oncology 41, no. 1 (2012): 61-66. https://doi.org/10.3892/ijo.2012.1454
Copy and paste a formatted citation
x
Spandidos Publications style
Umehara S, Fujiwara H, Shiozaki A, Todo M, Furutani A, Yoneda M, Ikai A, Tada H, Komatsu S, Ichikawa D, Ichikawa D, et al: PSK induces apoptosis through the inhibition of activated STAT3 in human esophageal carcinoma cells. Int J Oncol 41: 61-66, 2012.
APA
Umehara, S., Fujiwara, H., Shiozaki, A., Todo, M., Furutani, A., Yoneda, M. ... Otsuji, E. (2012). PSK induces apoptosis through the inhibition of activated STAT3 in human esophageal carcinoma cells. International Journal of Oncology, 41, 61-66. https://doi.org/10.3892/ijo.2012.1454
MLA
Umehara, S., Fujiwara, H., Shiozaki, A., Todo, M., Furutani, A., Yoneda, M., Ikai, A., Tada, H., Komatsu, S., Ichikawa, D., Okamoto, K., Ochiai, T., Kokuba, Y., Otsuji, E."PSK induces apoptosis through the inhibition of activated STAT3 in human esophageal carcinoma cells". International Journal of Oncology 41.1 (2012): 61-66.
Chicago
Umehara, S., Fujiwara, H., Shiozaki, A., Todo, M., Furutani, A., Yoneda, M., Ikai, A., Tada, H., Komatsu, S., Ichikawa, D., Okamoto, K., Ochiai, T., Kokuba, Y., Otsuji, E."PSK induces apoptosis through the inhibition of activated STAT3 in human esophageal carcinoma cells". International Journal of Oncology 41, no. 1 (2012): 61-66. https://doi.org/10.3892/ijo.2012.1454
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