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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May-2026 Volume 68 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

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An International Open Access Journal Devoted to General Medicine.

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Review Open Access

Enolase 1: A paradigm of metabolic enzyme moonlighting in tumorigenesis (Review)

  • Authors:
    • Xiaochen Ni
    • Mingsi Zhang
    • Kaiyuan Zhang
    • Chuhang Wang
    • Jianing Guo
    • Wei Fan
    • Linfeng Zheng
    • Tao Jiang
    • Guangji Zhang

  • View Affiliations / Copyright

    Affiliations: School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, P.R. China
    Copyright: © Ni et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 56
    |
    Published online on: March 12, 2026
       https://doi.org/10.3892/ijo.2026.5869
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Abstract

Enolase 1 (ENO1) plays a pivotal role in tumor development, recognized as a multifunctional oncogene across diverse cancers. Initially known for its central role in glycolysis, where it catalyzes the conversion of 2‑phosphoglycerate to phosphoenolpyruvate, the influence of ENO1 extends far beyond. Recent studies have unveiled its additional roles in promoting tumor progression through plasminogen receptor activity, nucleic acid binding activity and signaling functions. The function of ENO1 is intricately regulated by a wide array of post‑translational modifications, such as phosphorylation, ubiquitination, acetylation, methylation, succinylation and glycosylation. These modifications fine‑tune its enzymatic activity, stability and subcellular localization, thereby affecting tumor behavior. ENO1 holds significant diagnostic and prognostic value, with its expression levels closely linked to tumor malignancy and patient survival outcomes. In preclinical models, multiple therapeutic approaches targeting ENO1 have demonstrated tumor progression‑inhibiting effects. Consequently, drug development efforts centered on ENO1 are gaining momentum, with anticancer agents targeting this protein showing promising potential. As ENO1 emerges as a novel therapeutic target in oncology, the present review summarizes the latest research progress on ENO1 in the field of cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Ni X, Zhang M, Zhang K, Wang C, Guo J, Fan W, Zheng L, Jiang T and Zhang G: Enolase 1: A paradigm of metabolic enzyme moonlighting in tumorigenesis (Review). Int J Oncol 68: 56, 2026.
APA
Ni, X., Zhang, M., Zhang, K., Wang, C., Guo, J., Fan, W. ... Zhang, G. (2026). Enolase 1: A paradigm of metabolic enzyme moonlighting in tumorigenesis (Review). International Journal of Oncology, 68, 56. https://doi.org/10.3892/ijo.2026.5869
MLA
Ni, X., Zhang, M., Zhang, K., Wang, C., Guo, J., Fan, W., Zheng, L., Jiang, T., Zhang, G."Enolase 1: A paradigm of metabolic enzyme moonlighting in tumorigenesis (Review)". International Journal of Oncology 68.5 (2026): 56.
Chicago
Ni, X., Zhang, M., Zhang, K., Wang, C., Guo, J., Fan, W., Zheng, L., Jiang, T., Zhang, G."Enolase 1: A paradigm of metabolic enzyme moonlighting in tumorigenesis (Review)". International Journal of Oncology 68, no. 5 (2026): 56. https://doi.org/10.3892/ijo.2026.5869
Copy and paste a formatted citation
x
Spandidos Publications style
Ni X, Zhang M, Zhang K, Wang C, Guo J, Fan W, Zheng L, Jiang T and Zhang G: Enolase 1: A paradigm of metabolic enzyme moonlighting in tumorigenesis (Review). Int J Oncol 68: 56, 2026.
APA
Ni, X., Zhang, M., Zhang, K., Wang, C., Guo, J., Fan, W. ... Zhang, G. (2026). Enolase 1: A paradigm of metabolic enzyme moonlighting in tumorigenesis (Review). International Journal of Oncology, 68, 56. https://doi.org/10.3892/ijo.2026.5869
MLA
Ni, X., Zhang, M., Zhang, K., Wang, C., Guo, J., Fan, W., Zheng, L., Jiang, T., Zhang, G."Enolase 1: A paradigm of metabolic enzyme moonlighting in tumorigenesis (Review)". International Journal of Oncology 68.5 (2026): 56.
Chicago
Ni, X., Zhang, M., Zhang, K., Wang, C., Guo, J., Fan, W., Zheng, L., Jiang, T., Zhang, G."Enolase 1: A paradigm of metabolic enzyme moonlighting in tumorigenesis (Review)". International Journal of Oncology 68, no. 5 (2026): 56. https://doi.org/10.3892/ijo.2026.5869
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