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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May-2026 Volume 68 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International Journal of Functional Nutrition

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Article Open Access

Therapeutic implications of targeting cancer testis antigen MAGEA1 in cervical cancer

  • Authors:
    • Ayoung Kim
    • Jina Kim
    • Woori Kwak
    • Kyumin Mo
    • Soohyun Choe
    • Minyeong Jeon
    • Jisun Lee
    • Jun-Won Yun
    • Hyunho Yoon

  • View Affiliations / Copyright

    Affiliations: Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi 14662, Republic of Korea, Laboratory of Veterinary Toxicology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Republic of Korea
    Copyright: © Kim et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 57
    |
    Published online on: March 12, 2026
       https://doi.org/10.3892/ijo.2026.5870
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Abstract

MAGE family member A1 (MAGEA1), a cancer‑testis antigen (CTA), is aberrantly expressed in several malignancies such as lung and liver cancers. However, its role in cervical cancer remains to be elucidated. The present study investigated the functional significance and therapeutic potential of MAGEA1 in cervical cancer using lentiviral short hairpin RNA‑mediated knockdown, a series of functional assays, RNA sequencing (RNA‑seq), and nude mouse xenograft models. It was found that MAGEA1 was upregulated in cervical cancer cells and its knockdown substantially suppressed cell proliferation, migration, invasion, and in vivo tumor growth. RNA‑seq analysis further revealed that MAGEA1 silencing altered pathways related to apoptosis, DNA repair, and metabolism. Moreover, MAGEA1 knockdown enhanced chemosensitivity, indicating a potential role in mediating drug resistance. Collectively, the findings identified MAGEA1 as a key oncogenic driver in cervical cancer and highlighted its promise as both a prognostic biomarker and a therapeutic target, offering novel avenues for personalized treatment strategies in cervical cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Kim A, Kim J, Kwak W, Mo K, Choe S, Jeon M, Lee J, Yun J and Yoon H: Therapeutic implications of targeting cancer testis antigen MAGEA1 in cervical cancer. Int J Oncol 68: 57, 2026.
APA
Kim, A., Kim, J., Kwak, W., Mo, K., Choe, S., Jeon, M. ... Yoon, H. (2026). Therapeutic implications of targeting cancer testis antigen MAGEA1 in cervical cancer. International Journal of Oncology, 68, 57. https://doi.org/10.3892/ijo.2026.5870
MLA
Kim, A., Kim, J., Kwak, W., Mo, K., Choe, S., Jeon, M., Lee, J., Yun, J., Yoon, H."Therapeutic implications of targeting cancer testis antigen MAGEA1 in cervical cancer". International Journal of Oncology 68.5 (2026): 57.
Chicago
Kim, A., Kim, J., Kwak, W., Mo, K., Choe, S., Jeon, M., Lee, J., Yun, J., Yoon, H."Therapeutic implications of targeting cancer testis antigen MAGEA1 in cervical cancer". International Journal of Oncology 68, no. 5 (2026): 57. https://doi.org/10.3892/ijo.2026.5870
Copy and paste a formatted citation
x
Spandidos Publications style
Kim A, Kim J, Kwak W, Mo K, Choe S, Jeon M, Lee J, Yun J and Yoon H: Therapeutic implications of targeting cancer testis antigen MAGEA1 in cervical cancer. Int J Oncol 68: 57, 2026.
APA
Kim, A., Kim, J., Kwak, W., Mo, K., Choe, S., Jeon, M. ... Yoon, H. (2026). Therapeutic implications of targeting cancer testis antigen MAGEA1 in cervical cancer. International Journal of Oncology, 68, 57. https://doi.org/10.3892/ijo.2026.5870
MLA
Kim, A., Kim, J., Kwak, W., Mo, K., Choe, S., Jeon, M., Lee, J., Yun, J., Yoon, H."Therapeutic implications of targeting cancer testis antigen MAGEA1 in cervical cancer". International Journal of Oncology 68.5 (2026): 57.
Chicago
Kim, A., Kim, J., Kwak, W., Mo, K., Choe, S., Jeon, M., Lee, J., Yun, J., Yoon, H."Therapeutic implications of targeting cancer testis antigen MAGEA1 in cervical cancer". International Journal of Oncology 68, no. 5 (2026): 57. https://doi.org/10.3892/ijo.2026.5870
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