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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 2002 Volume 21 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2002 Volume 21 Issue 1

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Article

Effects of hyperglycemia on oxygenation, radiosensitivity and bioenergetic status of subcutaneous RIF-1 tumors

  • Authors:
    • L. Nadal-Desbarats
    • H. Poptani
    • P. Oprysko
    • W. T. Jenkins
    • T. M. Busch
    • D. S. Nelson
    • J. D. Glickson
    • C. J. Koch
    • S. M. Evans

  • View Affiliations

    Affiliations: Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
  • Published online on: July 1, 2002     https://doi.org/10.3892/ijo.21.1.103
  • Pages: 103-110
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Abstract

Since tissue oxygen tension is a balance between delivery and consumption of oxygen, considerable effort has been directed at increasing the former and/or decreasing the latter. Techniques to decrease the rate of cellular oxygen consumption (increasing the distance oxygen can diffuse into tissues) include increasing glycolysis by administering supra-physiologic levels of glucose. We have examined the effect of hyperglycemia produced by intravenous glucose infusion on the tissue oxygenation and radiation response of subcutaneously implanted murine radiation induced fibrosarcomas (RIF-1). A 0.3 M glucose solution was delivered via tail vein injection according to a protocol that maintained glucose at a plasma concentration of 17±1 mM. The effect of this treatment on radiation response (clonogenic and growth delay studies), tumor oxygenation (needle electrode pO2 and 2-[2-nitro-1H-imidazol-1-yl]-N-(2,2,3,3,3-pentafluoropropyl) acetamide (EF5) binding), and tumor bioenergetics and pH (31P NMR spectroscopy) was examined. Systemic measurements included hematocrit and blood glucose and lactate concentrations. The results of these studies suggest that these subcutaneously implanted RIF-1 tumors are both radiobiologically and metabolically hypoxic and that intravenous glucose infusion is not an effective method of modifying this metabolic state.

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Copy and paste a formatted citation
Spandidos Publications style
Nadal-Desbarats L, Poptani H, Oprysko P, Jenkins WT, Busch TM, Nelson DS, Glickson JD, Koch CJ and Evans SM: Effects of hyperglycemia on oxygenation, radiosensitivity and bioenergetic status of subcutaneous RIF-1 tumors. Int J Oncol 21: 103-110, 2002.
APA
Nadal-Desbarats, L., Poptani, H., Oprysko, P., Jenkins, W.T., Busch, T.M., Nelson, D.S. ... Evans, S.M. (2002). Effects of hyperglycemia on oxygenation, radiosensitivity and bioenergetic status of subcutaneous RIF-1 tumors. International Journal of Oncology, 21, 103-110. https://doi.org/10.3892/ijo.21.1.103
MLA
Nadal-Desbarats, L., Poptani, H., Oprysko, P., Jenkins, W. T., Busch, T. M., Nelson, D. S., Glickson, J. D., Koch, C. J., Evans, S. M."Effects of hyperglycemia on oxygenation, radiosensitivity and bioenergetic status of subcutaneous RIF-1 tumors". International Journal of Oncology 21.1 (2002): 103-110.
Chicago
Nadal-Desbarats, L., Poptani, H., Oprysko, P., Jenkins, W. T., Busch, T. M., Nelson, D. S., Glickson, J. D., Koch, C. J., Evans, S. M."Effects of hyperglycemia on oxygenation, radiosensitivity and bioenergetic status of subcutaneous RIF-1 tumors". International Journal of Oncology 21, no. 1 (2002): 103-110. https://doi.org/10.3892/ijo.21.1.103
Copy and paste a formatted citation
x
Spandidos Publications style
Nadal-Desbarats L, Poptani H, Oprysko P, Jenkins WT, Busch TM, Nelson DS, Glickson JD, Koch CJ and Evans SM: Effects of hyperglycemia on oxygenation, radiosensitivity and bioenergetic status of subcutaneous RIF-1 tumors. Int J Oncol 21: 103-110, 2002.
APA
Nadal-Desbarats, L., Poptani, H., Oprysko, P., Jenkins, W.T., Busch, T.M., Nelson, D.S. ... Evans, S.M. (2002). Effects of hyperglycemia on oxygenation, radiosensitivity and bioenergetic status of subcutaneous RIF-1 tumors. International Journal of Oncology, 21, 103-110. https://doi.org/10.3892/ijo.21.1.103
MLA
Nadal-Desbarats, L., Poptani, H., Oprysko, P., Jenkins, W. T., Busch, T. M., Nelson, D. S., Glickson, J. D., Koch, C. J., Evans, S. M."Effects of hyperglycemia on oxygenation, radiosensitivity and bioenergetic status of subcutaneous RIF-1 tumors". International Journal of Oncology 21.1 (2002): 103-110.
Chicago
Nadal-Desbarats, L., Poptani, H., Oprysko, P., Jenkins, W. T., Busch, T. M., Nelson, D. S., Glickson, J. D., Koch, C. J., Evans, S. M."Effects of hyperglycemia on oxygenation, radiosensitivity and bioenergetic status of subcutaneous RIF-1 tumors". International Journal of Oncology 21, no. 1 (2002): 103-110. https://doi.org/10.3892/ijo.21.1.103
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