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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 2002 Volume 21 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2002 Volume 21 Issue 1

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Review

Role of cyclinT/Cdk9 complex in basal and regulated transcription (Review)

  • Authors:
    • Giuliana Napolitano
    • Barbara Majello
    • Luigi Lania

  • View Affiliations / Copyright

    Affiliations: Department of Genetics, Molecular and General Biology, University of Naples <Federico II>, 80134 Naples, Italy
  • Pages: 171-177
    |
    Published online on: July 1, 2002
       https://doi.org/10.3892/ijo.21.1.171
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Abstract

Cell division and proliferation of all eukaryotics must follow a genetic program, termed the cell cycle. To ensure proper progression through the cell cycle, proteins that are intimately involved in its regulation must be periodically expressed within an appropriate window of the cycle. Cyclin and cyclin-dependent kinases are the modular components of the core clock machinery of the cell cycle. Progression through the cell cycle requires the activation of Cdks. The activities of these classes of kinases are tightly regulated by both positive and negative factors, and most importantly perturbation of Cdk activities can result in tumorigenesis. Progress has been made recently in connecting specific cyclin-Cdk kinase complexes and transcription. It is still unclear how cyclin/Cdk complexes regulate transcription, and most importantly what their substrates are. The aim of this review is to discuss our current understanding of the molecular mechanisms underlying the transcription properties of defined cyclin-dependent kinases, with a particular emphasis on the cyclin T/Cdk9 (P-TEFb) complex, and its role in the regulation of cell cycle controlling genes.

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Copy and paste a formatted citation
Spandidos Publications style
Napolitano G, Majello B and Lania L: Role of cyclinT/Cdk9 complex in basal and regulated transcription (Review). Int J Oncol 21: 171-177, 2002.
APA
Napolitano, G., Majello, B., & Lania, L. (2002). Role of cyclinT/Cdk9 complex in basal and regulated transcription (Review). International Journal of Oncology, 21, 171-177. https://doi.org/10.3892/ijo.21.1.171
MLA
Napolitano, G., Majello, B., Lania, L."Role of cyclinT/Cdk9 complex in basal and regulated transcription (Review)". International Journal of Oncology 21.1 (2002): 171-177.
Chicago
Napolitano, G., Majello, B., Lania, L."Role of cyclinT/Cdk9 complex in basal and regulated transcription (Review)". International Journal of Oncology 21, no. 1 (2002): 171-177. https://doi.org/10.3892/ijo.21.1.171
Copy and paste a formatted citation
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Spandidos Publications style
Napolitano G, Majello B and Lania L: Role of cyclinT/Cdk9 complex in basal and regulated transcription (Review). Int J Oncol 21: 171-177, 2002.
APA
Napolitano, G., Majello, B., & Lania, L. (2002). Role of cyclinT/Cdk9 complex in basal and regulated transcription (Review). International Journal of Oncology, 21, 171-177. https://doi.org/10.3892/ijo.21.1.171
MLA
Napolitano, G., Majello, B., Lania, L."Role of cyclinT/Cdk9 complex in basal and regulated transcription (Review)". International Journal of Oncology 21.1 (2002): 171-177.
Chicago
Napolitano, G., Majello, B., Lania, L."Role of cyclinT/Cdk9 complex in basal and regulated transcription (Review)". International Journal of Oncology 21, no. 1 (2002): 171-177. https://doi.org/10.3892/ijo.21.1.171
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