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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 2002 Volume 21 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2002 Volume 21 Issue 1

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Article

Thiazolidinedione, a peroxisome proliferator-activated receptor-γ ligand, modulates the E-cadherin/β-catenin system in a human pancreatic cancer cell line, BxPC-3

  • Authors:
    • T. Ohta
    • A. Elnemr
    • M. Yamamoto
    • I. Ninomiya
    • S. Fushida
    • G.-I. Nishimura
    • T. Fujimura
    • H. Kitagawa
    • M. Kayahara
    • K. Shimizu
    • S. Yi
    • K. Miwa
  • View Affiliations / Copyright

    Affiliations: Department of Surgery II, School of Medicine, Kanazawa University, Kanazawa 920-0934, Japan. ohtat@surg2.m.kanazawa-u.ac.jp
  • Pages: 37-42
    |
    Published online on: July 1, 2002
       https://doi.org/10.3892/ijo.21.1.37
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Abstract

Activation of peroxisome proliferator-activated receptor (PPAR)-γ induces terminal differentiation and growth inhibition associated with G1 cell cycle arrest in some cancer cells. The multifunctional molecule β-catenin performs important roles in intercellular adhesion and signal transduction. However, no report has focused on actions of PPAR-γ in regulating the E-cadherin/β-catenin system. We examined whether thiazolidinedione (TZD), a potent PPAR-γ ligand, could modulate the E-cadherin/β-catenin system in a human pancreatic cancer cell line, BxPC-3, that has been found to express PPAR-γ. According to Western blotting, TZD markedly increased differentiation markers including E-cadherin and carcinoembryonic antigen, while β-catenin did not change significantly. In untreated cells, fluorescence immunostaining demonstrated β-catenin predominantly in the cytoplasm and/or nucleus; in TZD-treated cells, β-catenin localization had dramatically shifted to the plasma membrane, in association with increased E-cadherin at this site. Thus, a PPAR-γ ligand appears to participate not only in induction of differentiation in pancreatic cancer cells, but also in the regulation of the E-cadherin/β-catenin system. Such ligands may prove clinically useful as cytostatic anticancer agents.

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Copy and paste a formatted citation
Spandidos Publications style
Ohta T, Elnemr A, Yamamoto M, Ninomiya I, Fushida S, Nishimura G, Fujimura T, Kitagawa H, Kayahara M, Shimizu K, Shimizu K, et al: Thiazolidinedione, a peroxisome proliferator-activated receptor-γ ligand, modulates the E-cadherin/β-catenin system in a human pancreatic cancer cell line, BxPC-3. Int J Oncol 21: 37-42, 2002.
APA
Ohta, T., Elnemr, A., Yamamoto, M., Ninomiya, I., Fushida, S., Nishimura, G. ... Miwa, K. (2002). Thiazolidinedione, a peroxisome proliferator-activated receptor-γ ligand, modulates the E-cadherin/β-catenin system in a human pancreatic cancer cell line, BxPC-3. International Journal of Oncology, 21, 37-42. https://doi.org/10.3892/ijo.21.1.37
MLA
Ohta, T., Elnemr, A., Yamamoto, M., Ninomiya, I., Fushida, S., Nishimura, G., Fujimura, T., Kitagawa, H., Kayahara, M., Shimizu, K., Yi, S., Miwa, K."Thiazolidinedione, a peroxisome proliferator-activated receptor-γ ligand, modulates the E-cadherin/β-catenin system in a human pancreatic cancer cell line, BxPC-3". International Journal of Oncology 21.1 (2002): 37-42.
Chicago
Ohta, T., Elnemr, A., Yamamoto, M., Ninomiya, I., Fushida, S., Nishimura, G., Fujimura, T., Kitagawa, H., Kayahara, M., Shimizu, K., Yi, S., Miwa, K."Thiazolidinedione, a peroxisome proliferator-activated receptor-γ ligand, modulates the E-cadherin/β-catenin system in a human pancreatic cancer cell line, BxPC-3". International Journal of Oncology 21, no. 1 (2002): 37-42. https://doi.org/10.3892/ijo.21.1.37
Copy and paste a formatted citation
x
Spandidos Publications style
Ohta T, Elnemr A, Yamamoto M, Ninomiya I, Fushida S, Nishimura G, Fujimura T, Kitagawa H, Kayahara M, Shimizu K, Shimizu K, et al: Thiazolidinedione, a peroxisome proliferator-activated receptor-γ ligand, modulates the E-cadherin/β-catenin system in a human pancreatic cancer cell line, BxPC-3. Int J Oncol 21: 37-42, 2002.
APA
Ohta, T., Elnemr, A., Yamamoto, M., Ninomiya, I., Fushida, S., Nishimura, G. ... Miwa, K. (2002). Thiazolidinedione, a peroxisome proliferator-activated receptor-γ ligand, modulates the E-cadherin/β-catenin system in a human pancreatic cancer cell line, BxPC-3. International Journal of Oncology, 21, 37-42. https://doi.org/10.3892/ijo.21.1.37
MLA
Ohta, T., Elnemr, A., Yamamoto, M., Ninomiya, I., Fushida, S., Nishimura, G., Fujimura, T., Kitagawa, H., Kayahara, M., Shimizu, K., Yi, S., Miwa, K."Thiazolidinedione, a peroxisome proliferator-activated receptor-γ ligand, modulates the E-cadherin/β-catenin system in a human pancreatic cancer cell line, BxPC-3". International Journal of Oncology 21.1 (2002): 37-42.
Chicago
Ohta, T., Elnemr, A., Yamamoto, M., Ninomiya, I., Fushida, S., Nishimura, G., Fujimura, T., Kitagawa, H., Kayahara, M., Shimizu, K., Yi, S., Miwa, K."Thiazolidinedione, a peroxisome proliferator-activated receptor-γ ligand, modulates the E-cadherin/β-catenin system in a human pancreatic cancer cell line, BxPC-3". International Journal of Oncology 21, no. 1 (2002): 37-42. https://doi.org/10.3892/ijo.21.1.37
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