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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 2002 Volume 21 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2002 Volume 21 Issue 1

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Article

Expression of p16, p27, p53, p73 and Nup88 proteins in matched primary and metastatic melanoma cells

  • Authors:
    • H. Zhang
    • J. Schneider
    • I. Rosdahl

  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, Clinical Research Center, Institute of Biomedicine and Surgery, Linkoping University, SE-581 85 Linkoping, Sweden. hong.zhang@mcb.liu.se
  • Pages: 43-48
    |
    Published online on: July 1, 2002
       https://doi.org/10.3892/ijo.21.1.43
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Abstract

Cutaneous melanoma is a tumor with high metastatic potential, but the mechanisms leading to progression are still not fully understood. In this study, we examined whether p16, p27, p53, p73 and Nup88 proteins were involved in the progression from primary to metastatic melanomas by immunocytochemistry and Western blotting in eleven melanoma cell lines from five matched primary and metastatic melanomas. We demonstrated that the primary and metastatic melanomas expressed differently p16, p27, p73 and Nup88 proteins. When expressed in the primary melanoma cells p16 and p27 were lost or reduced in almost all the metastatic melanoma cell lines. In contrast, p73 and Nup88 were expressed in most of the tested melanoma cell lines and were increased in the metastatic melanomas. p53 was expressed at the same level in both the primary and metastatic melanoma cells. These data suggest that a reduced expression of p16 and p27 and an enhanced expression of p73 and Nup88 might play an important role in the progression of melanoma from primary tumor to metastasis.

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Copy and paste a formatted citation
Spandidos Publications style
Zhang H, Schneider J and Rosdahl I: Expression of p16, p27, p53, p73 and Nup88 proteins in matched primary and metastatic melanoma cells. Int J Oncol 21: 43-48, 2002.
APA
Zhang, H., Schneider, J., & Rosdahl, I. (2002). Expression of p16, p27, p53, p73 and Nup88 proteins in matched primary and metastatic melanoma cells. International Journal of Oncology, 21, 43-48. https://doi.org/10.3892/ijo.21.1.43
MLA
Zhang, H., Schneider, J., Rosdahl, I."Expression of p16, p27, p53, p73 and Nup88 proteins in matched primary and metastatic melanoma cells". International Journal of Oncology 21.1 (2002): 43-48.
Chicago
Zhang, H., Schneider, J., Rosdahl, I."Expression of p16, p27, p53, p73 and Nup88 proteins in matched primary and metastatic melanoma cells". International Journal of Oncology 21, no. 1 (2002): 43-48. https://doi.org/10.3892/ijo.21.1.43
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang H, Schneider J and Rosdahl I: Expression of p16, p27, p53, p73 and Nup88 proteins in matched primary and metastatic melanoma cells. Int J Oncol 21: 43-48, 2002.
APA
Zhang, H., Schneider, J., & Rosdahl, I. (2002). Expression of p16, p27, p53, p73 and Nup88 proteins in matched primary and metastatic melanoma cells. International Journal of Oncology, 21, 43-48. https://doi.org/10.3892/ijo.21.1.43
MLA
Zhang, H., Schneider, J., Rosdahl, I."Expression of p16, p27, p53, p73 and Nup88 proteins in matched primary and metastatic melanoma cells". International Journal of Oncology 21.1 (2002): 43-48.
Chicago
Zhang, H., Schneider, J., Rosdahl, I."Expression of p16, p27, p53, p73 and Nup88 proteins in matched primary and metastatic melanoma cells". International Journal of Oncology 21, no. 1 (2002): 43-48. https://doi.org/10.3892/ijo.21.1.43
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