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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 2002 Volume 21 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2002 Volume 21 Issue 1

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Article

Ribozyme mediated suppression of vascular endothelial growth factor gene expression enhances matrix metalloproteinase 1 expression in a human hepatocellular carcinoma cell line

  • Authors:
    • Junichiro Kamochi
    • Tetsuji Tokunaga
    • Fumitoshi Morino
    • Junko Nagata
    • Yasushi Tomii
    • Yoshiyuki Abe
    • Hiroyuki Hatanaka
    • Hiroshi Kijima
    • Hitoshi Yamazaki
    • Norihito Watanabe
    • Shohei Matsuzaki
    • Yoshito Ueyama
    • Masato Nakamura
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259-1193, Japan
  • Pages: 81-84
    |
    Published online on: July 1, 2002
       https://doi.org/10.3892/ijo.21.1.81
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Abstract

The levels of expression of various genes were altered in cellular transformants with manipulation of expression of single genes. Vascular endothelial growth factor A (VEGF-A) is a key molecule for tumor progression, although it is unclear how VEGF-A expression regulates various genes. Multiple gene expression levels were evaluated using cDNA arrays in a human hepatocellular carcinoma cell line (HLF) with suppression of the VEGF-A gene by anti-VEGF-A ribozyme (αVRz). The ribozyme-mediated suppression of VEGF-A gene solely up-regulated matrix metalloproteinase 1 (MMP1) gene level in HLF/αVRz. Levels of expression of other members of MMP family or tissue inhibitors of MMPs did not show any alteration. These results suggested that intracellular suppression of VEGF-A gene was specifically linked to up-regulation of MMP1 in human hepatocellular carcinoma cells.

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Copy and paste a formatted citation
Spandidos Publications style
Kamochi J, Tokunaga T, Morino F, Nagata J, Tomii Y, Abe Y, Hatanaka H, Kijima H, Yamazaki H, Watanabe N, Watanabe N, et al: Ribozyme mediated suppression of vascular endothelial growth factor gene expression enhances matrix metalloproteinase 1 expression in a human hepatocellular carcinoma cell line. Int J Oncol 21: 81-84, 2002.
APA
Kamochi, J., Tokunaga, T., Morino, F., Nagata, J., Tomii, Y., Abe, Y. ... Nakamura, M. (2002). Ribozyme mediated suppression of vascular endothelial growth factor gene expression enhances matrix metalloproteinase 1 expression in a human hepatocellular carcinoma cell line. International Journal of Oncology, 21, 81-84. https://doi.org/10.3892/ijo.21.1.81
MLA
Kamochi, J., Tokunaga, T., Morino, F., Nagata, J., Tomii, Y., Abe, Y., Hatanaka, H., Kijima, H., Yamazaki, H., Watanabe, N., Matsuzaki, S., Ueyama, Y., Nakamura, M."Ribozyme mediated suppression of vascular endothelial growth factor gene expression enhances matrix metalloproteinase 1 expression in a human hepatocellular carcinoma cell line". International Journal of Oncology 21.1 (2002): 81-84.
Chicago
Kamochi, J., Tokunaga, T., Morino, F., Nagata, J., Tomii, Y., Abe, Y., Hatanaka, H., Kijima, H., Yamazaki, H., Watanabe, N., Matsuzaki, S., Ueyama, Y., Nakamura, M."Ribozyme mediated suppression of vascular endothelial growth factor gene expression enhances matrix metalloproteinase 1 expression in a human hepatocellular carcinoma cell line". International Journal of Oncology 21, no. 1 (2002): 81-84. https://doi.org/10.3892/ijo.21.1.81
Copy and paste a formatted citation
x
Spandidos Publications style
Kamochi J, Tokunaga T, Morino F, Nagata J, Tomii Y, Abe Y, Hatanaka H, Kijima H, Yamazaki H, Watanabe N, Watanabe N, et al: Ribozyme mediated suppression of vascular endothelial growth factor gene expression enhances matrix metalloproteinase 1 expression in a human hepatocellular carcinoma cell line. Int J Oncol 21: 81-84, 2002.
APA
Kamochi, J., Tokunaga, T., Morino, F., Nagata, J., Tomii, Y., Abe, Y. ... Nakamura, M. (2002). Ribozyme mediated suppression of vascular endothelial growth factor gene expression enhances matrix metalloproteinase 1 expression in a human hepatocellular carcinoma cell line. International Journal of Oncology, 21, 81-84. https://doi.org/10.3892/ijo.21.1.81
MLA
Kamochi, J., Tokunaga, T., Morino, F., Nagata, J., Tomii, Y., Abe, Y., Hatanaka, H., Kijima, H., Yamazaki, H., Watanabe, N., Matsuzaki, S., Ueyama, Y., Nakamura, M."Ribozyme mediated suppression of vascular endothelial growth factor gene expression enhances matrix metalloproteinase 1 expression in a human hepatocellular carcinoma cell line". International Journal of Oncology 21.1 (2002): 81-84.
Chicago
Kamochi, J., Tokunaga, T., Morino, F., Nagata, J., Tomii, Y., Abe, Y., Hatanaka, H., Kijima, H., Yamazaki, H., Watanabe, N., Matsuzaki, S., Ueyama, Y., Nakamura, M."Ribozyme mediated suppression of vascular endothelial growth factor gene expression enhances matrix metalloproteinase 1 expression in a human hepatocellular carcinoma cell line". International Journal of Oncology 21, no. 1 (2002): 81-84. https://doi.org/10.3892/ijo.21.1.81
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