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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 2002 Volume 21 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2002 Volume 21 Issue 1

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Article

Cyclin-dependent kinase inhibitor (roscovitine) suppresses growth and induces apoptosis by regulating Bcl-x in head and neck squamous cell carcinoma cells

  • Authors:
    • Mariko Mihara
    • Satoru Shintani
    • Akihisa Kiyota
    • Tomohiro Matsumura
    • David T.W. Wong

  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, Ehime University School of Medicine, Ehime 791-0295, Japan. mmariko@m.ehime-u.ac.jp
  • Pages: 95-101
    |
    Published online on: July 1, 2002
       https://doi.org/10.3892/ijo.21.1.95
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Abstract

Cyclin-dependent kinases (Cdks) play essential roles in the intracellular controls of the cell cycles. Roscovitine, [2-(R)-(1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine], is a potent and selective inhibitor of the Cdk2 and Cdc2. We investigated whether this compound was effective against head and neck squamous cell carcinoma (HNSCC) cells. Roscovitine was found to inhibit the growth of all 11 HNSCC cell lines in time- and dose-dependent manner and to diminish the Cdk2 and Cdc2 activities. An induction of apoptosis was observed in all cells, as judged by the cell morphology, along with the appearance of cells with sub-G1 DNA contents, DNA fragmentations, and poly(ADP-ribose) polymerase (PARP) cleavage. In four HNSCC cell lines, apoptosis was induced without antecedent marked cell cycle arrest, and in the other seven cell lines, cell cycle arrest preceded cell death. We also found up-regulation of Bcl-xS in the former cell lines, and in the latter cell lines, the expressions of Bcl-2 and Bcl-xL were induced simultaneously. These results suggest that roscovitine exerts antitumor activities in HNSCC and is associated with induction of Bcl-xS. Roscovitine can be considered to provide a new chemopreventive and chemotherapeutic strategy for the clinical management of HNSCC.

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Copy and paste a formatted citation
Spandidos Publications style
Mihara M, Shintani S, Kiyota A, Matsumura T and Wong DT: Cyclin-dependent kinase inhibitor (roscovitine) suppresses growth and induces apoptosis by regulating Bcl-x in head and neck squamous cell carcinoma cells. Int J Oncol 21: 95-101, 2002.
APA
Mihara, M., Shintani, S., Kiyota, A., Matsumura, T., & Wong, D.T. (2002). Cyclin-dependent kinase inhibitor (roscovitine) suppresses growth and induces apoptosis by regulating Bcl-x in head and neck squamous cell carcinoma cells. International Journal of Oncology, 21, 95-101. https://doi.org/10.3892/ijo.21.1.95
MLA
Mihara, M., Shintani, S., Kiyota, A., Matsumura, T., Wong, D. T."Cyclin-dependent kinase inhibitor (roscovitine) suppresses growth and induces apoptosis by regulating Bcl-x in head and neck squamous cell carcinoma cells". International Journal of Oncology 21.1 (2002): 95-101.
Chicago
Mihara, M., Shintani, S., Kiyota, A., Matsumura, T., Wong, D. T."Cyclin-dependent kinase inhibitor (roscovitine) suppresses growth and induces apoptosis by regulating Bcl-x in head and neck squamous cell carcinoma cells". International Journal of Oncology 21, no. 1 (2002): 95-101. https://doi.org/10.3892/ijo.21.1.95
Copy and paste a formatted citation
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Spandidos Publications style
Mihara M, Shintani S, Kiyota A, Matsumura T and Wong DT: Cyclin-dependent kinase inhibitor (roscovitine) suppresses growth and induces apoptosis by regulating Bcl-x in head and neck squamous cell carcinoma cells. Int J Oncol 21: 95-101, 2002.
APA
Mihara, M., Shintani, S., Kiyota, A., Matsumura, T., & Wong, D.T. (2002). Cyclin-dependent kinase inhibitor (roscovitine) suppresses growth and induces apoptosis by regulating Bcl-x in head and neck squamous cell carcinoma cells. International Journal of Oncology, 21, 95-101. https://doi.org/10.3892/ijo.21.1.95
MLA
Mihara, M., Shintani, S., Kiyota, A., Matsumura, T., Wong, D. T."Cyclin-dependent kinase inhibitor (roscovitine) suppresses growth and induces apoptosis by regulating Bcl-x in head and neck squamous cell carcinoma cells". International Journal of Oncology 21.1 (2002): 95-101.
Chicago
Mihara, M., Shintani, S., Kiyota, A., Matsumura, T., Wong, D. T."Cyclin-dependent kinase inhibitor (roscovitine) suppresses growth and induces apoptosis by regulating Bcl-x in head and neck squamous cell carcinoma cells". International Journal of Oncology 21, no. 1 (2002): 95-101. https://doi.org/10.3892/ijo.21.1.95
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