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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 2002 Volume 21 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2002 Volume 21 Issue 3

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Article

Cancer cell contact causes oscillatory and polarized rise of cytoplasmic ionized calcium concentration in human umbilical vein endothelial cells

  • Authors:
    • Yoshihisa Tsuji
    • Shoji Nakamori
    • Hideo Ariyoshi
    • Masato Sakon
    • Yasuhisa Aono
    • Atsushi Ueda
    • Masaru Tokunaga
    • Takashi Nakamura
    • Morito Monden

  • View Affiliations / Copyright

    Affiliations: Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan
  • Pages: 541-546
    |
    Published online on: September 1, 2002
       https://doi.org/10.3892/ijo.21.3.541
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Abstract

The rise of cytoplasmic ionized Ca2+ concentration ([Ca2+]i) is an important factor in cellular signal transduction, which regulates a variety of cellular functions in vascular endothelial cells (vECs) such as morphological change, secretion of vaso-active molecules, or endothelial permeability. It is also known that the loss of vEC integrity plays pivotal roles in several physiological or pathological phenomena, such as inflammation or cancer metastasis. The aim of this study was to clarify the mode of cancer cell induced vEC retraction by cell to cell contact. Digital imaging analysis using Ca2+ indicator, fluo-3, cleary demonstrated an oscillatory intracellular and intercellular [Ca2+]i wave originated from the site of human breast cancer cell line MCF-7 cell contact in HUVECs, which was not inhibited by extracellular Ni2+ and was inhibited by pretreating the cells by paraformaldehyde. Although this phenomenon could be observed in malignant cells including murine malignant melanoma cell line, BL6, as well as benign cells including human fibroblast cell line, WI38, innert neutrophils did not cause vEC retraction nor [Ca2+]i oscillation. Thus, cancer cells could activate vECs by a cell to cell contact to cause retraction via common property of non-blood cells.

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Copy and paste a formatted citation
Spandidos Publications style
Tsuji Y, Nakamori S, Ariyoshi H, Sakon M, Aono Y, Ueda A, Tokunaga M, Nakamura T and Monden M: Cancer cell contact causes oscillatory and polarized rise of cytoplasmic ionized calcium concentration in human umbilical vein endothelial cells. Int J Oncol 21: 541-546, 2002.
APA
Tsuji, Y., Nakamori, S., Ariyoshi, H., Sakon, M., Aono, Y., Ueda, A. ... Monden, M. (2002). Cancer cell contact causes oscillatory and polarized rise of cytoplasmic ionized calcium concentration in human umbilical vein endothelial cells. International Journal of Oncology, 21, 541-546. https://doi.org/10.3892/ijo.21.3.541
MLA
Tsuji, Y., Nakamori, S., Ariyoshi, H., Sakon, M., Aono, Y., Ueda, A., Tokunaga, M., Nakamura, T., Monden, M."Cancer cell contact causes oscillatory and polarized rise of cytoplasmic ionized calcium concentration in human umbilical vein endothelial cells". International Journal of Oncology 21.3 (2002): 541-546.
Chicago
Tsuji, Y., Nakamori, S., Ariyoshi, H., Sakon, M., Aono, Y., Ueda, A., Tokunaga, M., Nakamura, T., Monden, M."Cancer cell contact causes oscillatory and polarized rise of cytoplasmic ionized calcium concentration in human umbilical vein endothelial cells". International Journal of Oncology 21, no. 3 (2002): 541-546. https://doi.org/10.3892/ijo.21.3.541
Copy and paste a formatted citation
x
Spandidos Publications style
Tsuji Y, Nakamori S, Ariyoshi H, Sakon M, Aono Y, Ueda A, Tokunaga M, Nakamura T and Monden M: Cancer cell contact causes oscillatory and polarized rise of cytoplasmic ionized calcium concentration in human umbilical vein endothelial cells. Int J Oncol 21: 541-546, 2002.
APA
Tsuji, Y., Nakamori, S., Ariyoshi, H., Sakon, M., Aono, Y., Ueda, A. ... Monden, M. (2002). Cancer cell contact causes oscillatory and polarized rise of cytoplasmic ionized calcium concentration in human umbilical vein endothelial cells. International Journal of Oncology, 21, 541-546. https://doi.org/10.3892/ijo.21.3.541
MLA
Tsuji, Y., Nakamori, S., Ariyoshi, H., Sakon, M., Aono, Y., Ueda, A., Tokunaga, M., Nakamura, T., Monden, M."Cancer cell contact causes oscillatory and polarized rise of cytoplasmic ionized calcium concentration in human umbilical vein endothelial cells". International Journal of Oncology 21.3 (2002): 541-546.
Chicago
Tsuji, Y., Nakamori, S., Ariyoshi, H., Sakon, M., Aono, Y., Ueda, A., Tokunaga, M., Nakamura, T., Monden, M."Cancer cell contact causes oscillatory and polarized rise of cytoplasmic ionized calcium concentration in human umbilical vein endothelial cells". International Journal of Oncology 21, no. 3 (2002): 541-546. https://doi.org/10.3892/ijo.21.3.541
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