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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 2002 Volume 21 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2002 Volume 21 Issue 3

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Article

Alteration of intestinal putrescine uptake in tumour-bearing rats

  • Authors:
    • Gwenaelle Desury
    • Jacques-Philippe Moulinoux
    • Jean-Guy Delcros

  • View Affiliations / Copyright

    Affiliations: Groupe de Recherche En Therapeutiques AntiCancereuses (GRETAC), CNRS-FRE 2261, Faculte de Medecine, CS 34317, 35043 Rennes Cedex, France
  • Pages: 569-576
    |
    Published online on: September 1, 2002
       https://doi.org/10.3892/ijo.21.3.569
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Abstract

Polyamines are essential for rapidly dividing cells such as enterocytes and tumour cells. In both cells, polyamine pools are maintained by biosynthetic pathways along with active uptake systems. Because of their strategic position, enterocytes play an important role in the trafficking of luminal polyamines. The aim of this study was to determine whether the high polyamine demanding MAT-LyLu prostatic tumour alter the absorption and metabolism of putrescine in the small intestine tissue of rats. In vivo, after intragastric intubation of [14C]-putrescine, both the uptake of putrescine and its metabolic conversion into non-polyamine metabolites were enhanced in the small intestine of tumour-bearing rats. The presence of the tumour also altered the biodistribution of the radioactivity with a striking increased level of radioactivity in the plasma, which was probably the consequence of a higher net flux of putrescine from the lumen to the blood. Ex vivo studies using everted small intestine segments supported this hypothesis. The stimulation of putrescine uptake and metabolism in enterocytes of tumour-bearing animals may be an adaptation to compensate for the energy deficit caused by the competition with the tumour for nutrients and worsened by the tumour-associated cachexy.

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Copy and paste a formatted citation
Spandidos Publications style
Desury G, Moulinoux J and Delcros J: Alteration of intestinal putrescine uptake in tumour-bearing rats. Int J Oncol 21: 569-576, 2002.
APA
Desury, G., Moulinoux, J., & Delcros, J. (2002). Alteration of intestinal putrescine uptake in tumour-bearing rats. International Journal of Oncology, 21, 569-576. https://doi.org/10.3892/ijo.21.3.569
MLA
Desury, G., Moulinoux, J., Delcros, J."Alteration of intestinal putrescine uptake in tumour-bearing rats". International Journal of Oncology 21.3 (2002): 569-576.
Chicago
Desury, G., Moulinoux, J., Delcros, J."Alteration of intestinal putrescine uptake in tumour-bearing rats". International Journal of Oncology 21, no. 3 (2002): 569-576. https://doi.org/10.3892/ijo.21.3.569
Copy and paste a formatted citation
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Spandidos Publications style
Desury G, Moulinoux J and Delcros J: Alteration of intestinal putrescine uptake in tumour-bearing rats. Int J Oncol 21: 569-576, 2002.
APA
Desury, G., Moulinoux, J., & Delcros, J. (2002). Alteration of intestinal putrescine uptake in tumour-bearing rats. International Journal of Oncology, 21, 569-576. https://doi.org/10.3892/ijo.21.3.569
MLA
Desury, G., Moulinoux, J., Delcros, J."Alteration of intestinal putrescine uptake in tumour-bearing rats". International Journal of Oncology 21.3 (2002): 569-576.
Chicago
Desury, G., Moulinoux, J., Delcros, J."Alteration of intestinal putrescine uptake in tumour-bearing rats". International Journal of Oncology 21, no. 3 (2002): 569-576. https://doi.org/10.3892/ijo.21.3.569
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