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5-Aminolevulinic acid-based photodynamic detection and therapy of brain tumors (Review)

  • Authors:
    • Scott A. Friesen
    • Geir Olav Hjortland
    • Steen J. Madsen
    • Henry Hirschberg
    • Olav Engebraten
    • Jahn M. Nesland
    • Qian Peng

  • View Affiliations

  • Published online on: September 1, 2002     https://doi.org/10.3892/ijo.21.3.577
  • Pages: 577-582
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

With current treatment methods the prognosis for patients with aggressive brain tumors is dismal. Treatment failure is usually due to local recurrence of tumor. Intra-operative photodynamic detection (PDD) of tumor tissue and post-surgical photodynamic therapy (PDT) of the resection cavity may be of benefit. The utility of 5-aminolevulinic acid (ALA) has been recognized in many different treatment fields over the past decade. Following administration of exogenous ALA, the endogenous photosensitizer, protoporphyrin IX (PpIX), accumulates in tumor tissue. A photodynamic effect occurs upon light activation of the target tissue. This article reviews the current preclinical and clinical studies and potential future applications of ALA and its ester-induced PpIX as a photosensitizing agent in the detection and treatment of brain tumors.

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Journal Cover

September 2002
Volume 21 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Journal Metrics
  • Impact Factor: 5.2
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 11.4
  • CiteScore Rank: Q1: #40/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 1.125
  • SCImago Journal Rank (SJR): 1.105
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Spandidos Publications style
Friesen SA, Hjortland GO, Madsen SJ, Hirschberg H, Engebraten O, Nesland JM and Peng Q: 5-Aminolevulinic acid-based photodynamic detection and therapy of brain tumors (Review). Int J Oncol 21: 577-582, 2002
APA
Friesen, S.A., Hjortland, G.O., Madsen, S.J., Hirschberg, H., Engebraten, O., Nesland, J.M., & Peng, Q. (2002). 5-Aminolevulinic acid-based photodynamic detection and therapy of brain tumors (Review). International Journal of Oncology, 21, 577-582. https://doi.org/10.3892/ijo.21.3.577
MLA
Friesen, S. A., Hjortland, G. O., Madsen, S. J., Hirschberg, H., Engebraten, O., Nesland, J. M., Peng, Q."5-Aminolevulinic acid-based photodynamic detection and therapy of brain tumors (Review)". International Journal of Oncology 21.3 (2002): 577-582.
Chicago
Friesen, S. A., Hjortland, G. O., Madsen, S. J., Hirschberg, H., Engebraten, O., Nesland, J. M., Peng, Q."5-Aminolevulinic acid-based photodynamic detection and therapy of brain tumors (Review)". International Journal of Oncology 21, no. 3 (2002): 577-582. https://doi.org/10.3892/ijo.21.3.577