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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 2002 Volume 21 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2002 Volume 21 Issue 3

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Article

Supra-additive antitumor activity of 5FU with tumor necrosis factor-related apoptosis-inducing ligand on gastric and colon cancers in vitro

  • Authors:
    • Shouji Shimoyama
    • Yoshino Mochizuki
    • Osamu Kusada
    • Michio Kaminishi

  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, University of Tokyo, Tokyo 113-8655, Japan. shimoyama-dis@h.u-tokyo.ac.jp
  • Pages: 643-648
    |
    Published online on: September 1, 2002
       https://doi.org/10.3892/ijo.21.3.643
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Abstract

We investigated supra-additive cytotoxic effects of 5-fluorouracil (5FU) on gastric and colon cancer cells with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in vitro. p53 wild- and mutant-type gastric and colon cancer cell lines were treated by 5FU alone, TRAIL alone, and a combination of 5FU and TRAIL, and cell viability after each treatment was determined by MTT assay. The p53 wild-type cells were more sensitive to 5FU alone or to TRAIL alone than p53 mutant-type cells. The cell growth inhibitory effects of the combined treatment were supra-additive and more significant in proportion to the increasing concentrations of TRAIL as compared with 5FU alone both in p53 wild- and mutant-type cells. Furthermore, TRAIL could cause a decrease in 5FU IC50 to within the range of clinically relevant doses, particularly in p53 wild-type cells. This is the first demonstration of the supra-additive antitumor activity of 5FU with TRAIL on gastric cancer cells, giving evidence that TRAIL can reduce the requirement for 5FU that ultimately results in minimizing risks for systemic side effects while increasing the antitumor activity of 5FU, suggesting the clinical applicability of this combination for gastric and colon cancers.

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Copy and paste a formatted citation
Spandidos Publications style
Shimoyama S, Mochizuki Y, Kusada O and Kaminishi M: Supra-additive antitumor activity of 5FU with tumor necrosis factor-related apoptosis-inducing ligand on gastric and colon cancers in vitro. Int J Oncol 21: 643-648, 2002.
APA
Shimoyama, S., Mochizuki, Y., Kusada, O., & Kaminishi, M. (2002). Supra-additive antitumor activity of 5FU with tumor necrosis factor-related apoptosis-inducing ligand on gastric and colon cancers in vitro. International Journal of Oncology, 21, 643-648. https://doi.org/10.3892/ijo.21.3.643
MLA
Shimoyama, S., Mochizuki, Y., Kusada, O., Kaminishi, M."Supra-additive antitumor activity of 5FU with tumor necrosis factor-related apoptosis-inducing ligand on gastric and colon cancers in vitro". International Journal of Oncology 21.3 (2002): 643-648.
Chicago
Shimoyama, S., Mochizuki, Y., Kusada, O., Kaminishi, M."Supra-additive antitumor activity of 5FU with tumor necrosis factor-related apoptosis-inducing ligand on gastric and colon cancers in vitro". International Journal of Oncology 21, no. 3 (2002): 643-648. https://doi.org/10.3892/ijo.21.3.643
Copy and paste a formatted citation
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Spandidos Publications style
Shimoyama S, Mochizuki Y, Kusada O and Kaminishi M: Supra-additive antitumor activity of 5FU with tumor necrosis factor-related apoptosis-inducing ligand on gastric and colon cancers in vitro. Int J Oncol 21: 643-648, 2002.
APA
Shimoyama, S., Mochizuki, Y., Kusada, O., & Kaminishi, M. (2002). Supra-additive antitumor activity of 5FU with tumor necrosis factor-related apoptosis-inducing ligand on gastric and colon cancers in vitro. International Journal of Oncology, 21, 643-648. https://doi.org/10.3892/ijo.21.3.643
MLA
Shimoyama, S., Mochizuki, Y., Kusada, O., Kaminishi, M."Supra-additive antitumor activity of 5FU with tumor necrosis factor-related apoptosis-inducing ligand on gastric and colon cancers in vitro". International Journal of Oncology 21.3 (2002): 643-648.
Chicago
Shimoyama, S., Mochizuki, Y., Kusada, O., Kaminishi, M."Supra-additive antitumor activity of 5FU with tumor necrosis factor-related apoptosis-inducing ligand on gastric and colon cancers in vitro". International Journal of Oncology 21, no. 3 (2002): 643-648. https://doi.org/10.3892/ijo.21.3.643
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