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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 2002 Volume 21 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2002 Volume 21 Issue 4

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Review

IVIg to prevent tumor metastases (Review)

  • Authors:
    • Pnina Fishman
    • Sara Bar-Yehuda
    • Yehuda Shoenfeld

  • View Affiliations / Copyright

    Affiliations: Felsenstein Medical Research Center, Rabin Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Petach-Tikva 49100, Israel
  • Pages: 875-880
    |
    Published online on: October 1, 2002
       https://doi.org/10.3892/ijo.21.4.875
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Abstract

Intravenous γ globulin (IVIg) is produced from a pool of precipitated IgG from over 3,000 healthy donors. IVIg was originally given to subjects with Igs deficiencies. Later on its beneficial effects on a diverse autoimmune clinical conditions were revealed. Based on large experimental studies in mice as well as limited clinical experience, we consider IVIg useful in preventing metastatic spread. In mice, the employment of IVIg reduced significantly metastatic spread of melanoma, carcinoma and sarcoma. The effect of IVIg was achieved following i.v. or s.c. administration at high dose (2 g/kg body weight) and at 100 times lower doses. The effect of IVIg on the prevention of metastases are diverse and achieved via enhancement of IL-12 secretion and increased NK activity as well as inhibition of matrix metalloproteinase-9 (MMP-9). The lack of serious side effects with the remarkable decrease in metastatic spread make IVIg a suitable adjuvant therapy in early and advanced cancer conditions.

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Copy and paste a formatted citation
Spandidos Publications style
Fishman P, Bar-Yehuda S and Shoenfeld Y: IVIg to prevent tumor metastases (Review). Int J Oncol 21: 875-880, 2002.
APA
Fishman, P., Bar-Yehuda, S., & Shoenfeld, Y. (2002). IVIg to prevent tumor metastases (Review). International Journal of Oncology, 21, 875-880. https://doi.org/10.3892/ijo.21.4.875
MLA
Fishman, P., Bar-Yehuda, S., Shoenfeld, Y."IVIg to prevent tumor metastases (Review)". International Journal of Oncology 21.4 (2002): 875-880.
Chicago
Fishman, P., Bar-Yehuda, S., Shoenfeld, Y."IVIg to prevent tumor metastases (Review)". International Journal of Oncology 21, no. 4 (2002): 875-880. https://doi.org/10.3892/ijo.21.4.875
Copy and paste a formatted citation
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Spandidos Publications style
Fishman P, Bar-Yehuda S and Shoenfeld Y: IVIg to prevent tumor metastases (Review). Int J Oncol 21: 875-880, 2002.
APA
Fishman, P., Bar-Yehuda, S., & Shoenfeld, Y. (2002). IVIg to prevent tumor metastases (Review). International Journal of Oncology, 21, 875-880. https://doi.org/10.3892/ijo.21.4.875
MLA
Fishman, P., Bar-Yehuda, S., Shoenfeld, Y."IVIg to prevent tumor metastases (Review)". International Journal of Oncology 21.4 (2002): 875-880.
Chicago
Fishman, P., Bar-Yehuda, S., Shoenfeld, Y."IVIg to prevent tumor metastases (Review)". International Journal of Oncology 21, no. 4 (2002): 875-880. https://doi.org/10.3892/ijo.21.4.875
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