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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 2002 Volume 21 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2002 Volume 21 Issue 5

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Article

Genetic profile, PTEN mutation and therapeutic role of PTEN in glioblastomas

  • Authors:
    • Xing Fan
    • Yan Aalto
    • Stephen G. Sanko
    • Sakari Knuutila
    • David Klatzmann
    • Javier S. Castresana

  • View Affiliations / Copyright

    Affiliations: Molecular Neuro-Oncology Laboratory, University of Navarre Medical School, Pamplona, Spain
  • Pages: 1141-1150
    |
    Published online on: November 1, 2002
       https://doi.org/10.3892/ijo.21.5.1141
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Abstract

New therapeutic strategies are needed to improve survival in glioblastoma (GBM) the most malignant astrocytic tumor. We evaluated: a) the genetic status of 22 GBMs by comparative genomic hybridization (CGH); b) the specific role of mutation and/or homozygous deletion of PTEN in the genesis of GBM; and c) the possible therapeutic role of PTEN against GBM, in vitro. CGH demonstrated that the most frequent region of gain was at chromosome 7p, whereas the most frequent losses occurred at chromosomes 10q and 13q. Losses at chromosome 10 were found in 36% of patients, and PTEN was mutated in 27% of the 22 GBMs, including 4 point mutations and 2 homozygous deletions. The possible therapeutic role of PTEN in GBM was also studied in a system based on retroviral infection of the GBM cell line A172, homozygously deleted at the PTEN locus. A172 growth and proliferation rate were reduced by 50% after PTEN transduction. Moreover, we showed that inhibition of cell growth occurred through the PI3K/Akt/p27 pathway. Our findings suggest that PTEN participates in the genesis of GBM, and might be further studied as a candidate therapeutic agent in other testing systems.

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Copy and paste a formatted citation
Spandidos Publications style
Fan X, Aalto Y, Sanko SG, Knuutila S, Klatzmann D and Castresana JS: Genetic profile, PTEN mutation and therapeutic role of PTEN in glioblastomas. Int J Oncol 21: 1141-1150, 2002.
APA
Fan, X., Aalto, Y., Sanko, S.G., Knuutila, S., Klatzmann, D., & Castresana, J.S. (2002). Genetic profile, PTEN mutation and therapeutic role of PTEN in glioblastomas. International Journal of Oncology, 21, 1141-1150. https://doi.org/10.3892/ijo.21.5.1141
MLA
Fan, X., Aalto, Y., Sanko, S. G., Knuutila, S., Klatzmann, D., Castresana, J. S."Genetic profile, PTEN mutation and therapeutic role of PTEN in glioblastomas". International Journal of Oncology 21.5 (2002): 1141-1150.
Chicago
Fan, X., Aalto, Y., Sanko, S. G., Knuutila, S., Klatzmann, D., Castresana, J. S."Genetic profile, PTEN mutation and therapeutic role of PTEN in glioblastomas". International Journal of Oncology 21, no. 5 (2002): 1141-1150. https://doi.org/10.3892/ijo.21.5.1141
Copy and paste a formatted citation
x
Spandidos Publications style
Fan X, Aalto Y, Sanko SG, Knuutila S, Klatzmann D and Castresana JS: Genetic profile, PTEN mutation and therapeutic role of PTEN in glioblastomas. Int J Oncol 21: 1141-1150, 2002.
APA
Fan, X., Aalto, Y., Sanko, S.G., Knuutila, S., Klatzmann, D., & Castresana, J.S. (2002). Genetic profile, PTEN mutation and therapeutic role of PTEN in glioblastomas. International Journal of Oncology, 21, 1141-1150. https://doi.org/10.3892/ijo.21.5.1141
MLA
Fan, X., Aalto, Y., Sanko, S. G., Knuutila, S., Klatzmann, D., Castresana, J. S."Genetic profile, PTEN mutation and therapeutic role of PTEN in glioblastomas". International Journal of Oncology 21.5 (2002): 1141-1150.
Chicago
Fan, X., Aalto, Y., Sanko, S. G., Knuutila, S., Klatzmann, D., Castresana, J. S."Genetic profile, PTEN mutation and therapeutic role of PTEN in glioblastomas". International Journal of Oncology 21, no. 5 (2002): 1141-1150. https://doi.org/10.3892/ijo.21.5.1141
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