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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2002 Volume 21 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2002 Volume 21 Issue 6

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Review

Adenoviral gene therapy for cancer: From vectors to targeted and replication competent agents (Review)

  • Authors:
    • Gerd J. Bauerschmitz
    • Shannon D. Barker
    • Akseli Hemminki

  • View Affiliations / Copyright

    Affiliations: Division of Human Gene Therapy, Departments of Medicine, Pathology and Surgery, University of Alabama at Birmingham, Birmingham, AL 35294-3300, USA
  • Pages: 1161-1174
    |
    Published online on: December 1, 2002
       https://doi.org/10.3892/ijo.21.6.1161
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Abstract

Gene therapy is an exciting novel approach for treating cancers resistant to currently available modalities. Treatment approaches are based on taking advantage of molecular differences between normal and tumor cells. Various strategies are currently in clinical development, with some promising early results reported with mutation compensation, molecular chemotherapy and replication competent viruses. Adenoviruses are among the most popular vehicles and there is a wealth of clinical data suggesting excellent safety for treatment of cancer patients. Current developments include improving targeting strategies for gene delivery to tumor cells with tumor specific promoters. Another rapidly developing field is replication competent agents, which allow improved tumor penetration and local amplification of the anti-tumor effect. Further, infectivity enhancement strategies can overcome variable expression of the primary adenovirus receptor on tumor cells, which may have reduced the clinical efficacy of previous strategies. Adenoviral cancer gene therapy approaches lack cross-resistance with other treatment options and frequently synergistic effects can be observed. Therefore, the first routine clinical applications are likely to be combination treatments.

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Copy and paste a formatted citation
Spandidos Publications style
Bauerschmitz GJ, Barker SD and Hemminki A: Adenoviral gene therapy for cancer: From vectors to targeted and replication competent agents (Review). Int J Oncol 21: 1161-1174, 2002.
APA
Bauerschmitz, G.J., Barker, S.D., & Hemminki, A. (2002). Adenoviral gene therapy for cancer: From vectors to targeted and replication competent agents (Review). International Journal of Oncology, 21, 1161-1174. https://doi.org/10.3892/ijo.21.6.1161
MLA
Bauerschmitz, G. J., Barker, S. D., Hemminki, A."Adenoviral gene therapy for cancer: From vectors to targeted and replication competent agents (Review)". International Journal of Oncology 21.6 (2002): 1161-1174.
Chicago
Bauerschmitz, G. J., Barker, S. D., Hemminki, A."Adenoviral gene therapy for cancer: From vectors to targeted and replication competent agents (Review)". International Journal of Oncology 21, no. 6 (2002): 1161-1174. https://doi.org/10.3892/ijo.21.6.1161
Copy and paste a formatted citation
x
Spandidos Publications style
Bauerschmitz GJ, Barker SD and Hemminki A: Adenoviral gene therapy for cancer: From vectors to targeted and replication competent agents (Review). Int J Oncol 21: 1161-1174, 2002.
APA
Bauerschmitz, G.J., Barker, S.D., & Hemminki, A. (2002). Adenoviral gene therapy for cancer: From vectors to targeted and replication competent agents (Review). International Journal of Oncology, 21, 1161-1174. https://doi.org/10.3892/ijo.21.6.1161
MLA
Bauerschmitz, G. J., Barker, S. D., Hemminki, A."Adenoviral gene therapy for cancer: From vectors to targeted and replication competent agents (Review)". International Journal of Oncology 21.6 (2002): 1161-1174.
Chicago
Bauerschmitz, G. J., Barker, S. D., Hemminki, A."Adenoviral gene therapy for cancer: From vectors to targeted and replication competent agents (Review)". International Journal of Oncology 21, no. 6 (2002): 1161-1174. https://doi.org/10.3892/ijo.21.6.1161
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