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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2002 Volume 21 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2002 Volume 21 Issue 6

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Article

Identifying cancer-related genes in nasopharyngeal carcinoma cell lines using DNA and mRNA expression profiling analyses

  • Authors:
    • Xiang Guo
    • Weng-Onn Lui
    • Chao-Nan Qian
    • Jin-Dong Chen
    • Steven George Gray
    • Daniel Rhodes
    • Brian Haab
    • Eric Stanbridge
    • Huimin Wang
    • Ming-Huang Hong
    • Hua-Qing Min
    • Catharina Larsson
    • Bin Tean Teh

  • View Affiliations / Copyright

    Affiliations: Laboratory of Cancer Genetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA
  • Pages: 1197-1204
    |
    Published online on: December 1, 2002
       https://doi.org/10.3892/ijo.21.6.1197
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Abstract

The goals of this study were to evaluate the potential of detecting cryptic amplification and deletion of cancer-related genes using array-based comparative genomic hybridization (CGH), and to identify candidate cancer genes by combined parallel analyses of copy number and gene expression profiles in nasopharyngeal carcinoma (NPC) cell lines. We established global DNA copy number and mRNA expression profiles on human NPC cell lines using a high-density cDNA microarray. The DNA copy number alterations detected by array CGH were compared to the DNA copy number variations identified by metaphase CGH. A cryptic amplification at 3q26 was detected by array CGH, which was not found by metaphase CGH. By amplicon mapping and parallel analyses of DNA copy number and mRNA expression levels, we identified several candidates which could be important mediators in tumor formation or progression. Taken together, the combination of copy number and gene expression profiling using cDNA microarrays provides an improved strategy for gene discovery in human cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Guo X, Lui W, Qian C, Chen J, Gray SG, Rhodes D, Haab B, Stanbridge E, Wang H, Hong M, Hong M, et al: Identifying cancer-related genes in nasopharyngeal carcinoma cell lines using DNA and mRNA expression profiling analyses. Int J Oncol 21: 1197-1204, 2002.
APA
Guo, X., Lui, W., Qian, C., Chen, J., Gray, S.G., Rhodes, D. ... Teh, B.T. (2002). Identifying cancer-related genes in nasopharyngeal carcinoma cell lines using DNA and mRNA expression profiling analyses. International Journal of Oncology, 21, 1197-1204. https://doi.org/10.3892/ijo.21.6.1197
MLA
Guo, X., Lui, W., Qian, C., Chen, J., Gray, S. G., Rhodes, D., Haab, B., Stanbridge, E., Wang, H., Hong, M., Min, H., Larsson, C., Teh, B. T."Identifying cancer-related genes in nasopharyngeal carcinoma cell lines using DNA and mRNA expression profiling analyses". International Journal of Oncology 21.6 (2002): 1197-1204.
Chicago
Guo, X., Lui, W., Qian, C., Chen, J., Gray, S. G., Rhodes, D., Haab, B., Stanbridge, E., Wang, H., Hong, M., Min, H., Larsson, C., Teh, B. T."Identifying cancer-related genes in nasopharyngeal carcinoma cell lines using DNA and mRNA expression profiling analyses". International Journal of Oncology 21, no. 6 (2002): 1197-1204. https://doi.org/10.3892/ijo.21.6.1197
Copy and paste a formatted citation
x
Spandidos Publications style
Guo X, Lui W, Qian C, Chen J, Gray SG, Rhodes D, Haab B, Stanbridge E, Wang H, Hong M, Hong M, et al: Identifying cancer-related genes in nasopharyngeal carcinoma cell lines using DNA and mRNA expression profiling analyses. Int J Oncol 21: 1197-1204, 2002.
APA
Guo, X., Lui, W., Qian, C., Chen, J., Gray, S.G., Rhodes, D. ... Teh, B.T. (2002). Identifying cancer-related genes in nasopharyngeal carcinoma cell lines using DNA and mRNA expression profiling analyses. International Journal of Oncology, 21, 1197-1204. https://doi.org/10.3892/ijo.21.6.1197
MLA
Guo, X., Lui, W., Qian, C., Chen, J., Gray, S. G., Rhodes, D., Haab, B., Stanbridge, E., Wang, H., Hong, M., Min, H., Larsson, C., Teh, B. T."Identifying cancer-related genes in nasopharyngeal carcinoma cell lines using DNA and mRNA expression profiling analyses". International Journal of Oncology 21.6 (2002): 1197-1204.
Chicago
Guo, X., Lui, W., Qian, C., Chen, J., Gray, S. G., Rhodes, D., Haab, B., Stanbridge, E., Wang, H., Hong, M., Min, H., Larsson, C., Teh, B. T."Identifying cancer-related genes in nasopharyngeal carcinoma cell lines using DNA and mRNA expression profiling analyses". International Journal of Oncology 21, no. 6 (2002): 1197-1204. https://doi.org/10.3892/ijo.21.6.1197
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