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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2002 Volume 21 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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December 2002 Volume 21 Issue 6

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Article

Unique properties of 189 amino acid isoform of vascular endothelial growth factor in tumorigenesis

  • Authors:
    • Yasushi Tomii
    • Hitoshi Yamazaki
    • Nobuko Sawa
    • Yasuyuki Ohnishi
    • Junichiro Kamochi
    • Tetsuji Tokunaga
    • Yoshiyuki Osamura
    • Sotaro Sadahiro
    • Hiroshi Kijima
    • Yoshiyuki Abe
    • Yoshito Ueyama
    • Norikazu Tamaoki
    • Masato Nakamura

  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259-1193, Japan
  • Pages: 1251-1257
    |
    Published online on: December 1, 2002
       https://doi.org/10.3892/ijo.21.6.1251
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Abstract

The 189 amino acid isoform of vascular endothelial growth factor (VEGF189) has been shown to be more strongly associated with the cell membrane than other isoforms of human VEGF (VEGF121, VEGF165). To analyze the biological activities of these VEGF isoforms on tumor growth, we transfected human VEGF121, VEGF165 or VEGF189 cDNA into the human colon cancer cell line SW-480, and established several clones overexpressing these VEGF isoforms. The total amounts of VEGF protein in the culture supernatants of the VEGF189-transfectants were less than those of VEGF121 and VEGF165-transfectants. These transfectants showed no significant differences in growth in culture. Nevertheless, the rate of in vivo tumor growth of VEGF189-transfectants was faster than or equivalent to that of VEGF121-transfectants, while the VEGF165-transfectant showed the greatest enhancement of tumor growth. The protein levels of VEGF were markedly increased only in the VEGF189-transfectants cultured in the presence of heparin. The enhanced in vivo tumor growth of VEGF189-transfectants can be partly explained by the cell-associated features of VEGF189 molecules. The VEGF189 molecule, which is strongly bound to the cell surface, has unique properties and high potential in local angiogenesis and tumor growth in the cancer inductive microenvironment.

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Copy and paste a formatted citation
Spandidos Publications style
Tomii Y, Yamazaki H, Sawa N, Ohnishi Y, Kamochi J, Tokunaga T, Osamura Y, Sadahiro S, Kijima H, Abe Y, Abe Y, et al: Unique properties of 189 amino acid isoform of vascular endothelial growth factor in tumorigenesis. Int J Oncol 21: 1251-1257, 2002.
APA
Tomii, Y., Yamazaki, H., Sawa, N., Ohnishi, Y., Kamochi, J., Tokunaga, T. ... Nakamura, M. (2002). Unique properties of 189 amino acid isoform of vascular endothelial growth factor in tumorigenesis. International Journal of Oncology, 21, 1251-1257. https://doi.org/10.3892/ijo.21.6.1251
MLA
Tomii, Y., Yamazaki, H., Sawa, N., Ohnishi, Y., Kamochi, J., Tokunaga, T., Osamura, Y., Sadahiro, S., Kijima, H., Abe, Y., Ueyama, Y., Tamaoki, N., Nakamura, M."Unique properties of 189 amino acid isoform of vascular endothelial growth factor in tumorigenesis". International Journal of Oncology 21.6 (2002): 1251-1257.
Chicago
Tomii, Y., Yamazaki, H., Sawa, N., Ohnishi, Y., Kamochi, J., Tokunaga, T., Osamura, Y., Sadahiro, S., Kijima, H., Abe, Y., Ueyama, Y., Tamaoki, N., Nakamura, M."Unique properties of 189 amino acid isoform of vascular endothelial growth factor in tumorigenesis". International Journal of Oncology 21, no. 6 (2002): 1251-1257. https://doi.org/10.3892/ijo.21.6.1251
Copy and paste a formatted citation
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Spandidos Publications style
Tomii Y, Yamazaki H, Sawa N, Ohnishi Y, Kamochi J, Tokunaga T, Osamura Y, Sadahiro S, Kijima H, Abe Y, Abe Y, et al: Unique properties of 189 amino acid isoform of vascular endothelial growth factor in tumorigenesis. Int J Oncol 21: 1251-1257, 2002.
APA
Tomii, Y., Yamazaki, H., Sawa, N., Ohnishi, Y., Kamochi, J., Tokunaga, T. ... Nakamura, M. (2002). Unique properties of 189 amino acid isoform of vascular endothelial growth factor in tumorigenesis. International Journal of Oncology, 21, 1251-1257. https://doi.org/10.3892/ijo.21.6.1251
MLA
Tomii, Y., Yamazaki, H., Sawa, N., Ohnishi, Y., Kamochi, J., Tokunaga, T., Osamura, Y., Sadahiro, S., Kijima, H., Abe, Y., Ueyama, Y., Tamaoki, N., Nakamura, M."Unique properties of 189 amino acid isoform of vascular endothelial growth factor in tumorigenesis". International Journal of Oncology 21.6 (2002): 1251-1257.
Chicago
Tomii, Y., Yamazaki, H., Sawa, N., Ohnishi, Y., Kamochi, J., Tokunaga, T., Osamura, Y., Sadahiro, S., Kijima, H., Abe, Y., Ueyama, Y., Tamaoki, N., Nakamura, M."Unique properties of 189 amino acid isoform of vascular endothelial growth factor in tumorigenesis". International Journal of Oncology 21, no. 6 (2002): 1251-1257. https://doi.org/10.3892/ijo.21.6.1251
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