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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2002 Volume 21 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2002 Volume 21 Issue 6

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Article

Phosphorylation of p53, induction of Bax and activation of caspases during β-lapachone-mediated apoptosis in human prostate epithelial cells

  • Authors:
    • Yung Hyun Choi
    • Mi Jung Kim
    • Seung Yeon Lee
    • Youl-Nam Lee
    • Gyoo Yong Chi
    • Hyun Sup Eom
    • Nam Deuk Kim
    • Byung Tae Choi

  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, Dong-Eui University College, Pusan 614-052, Korea. choiyh@dongeui.ac.kr
  • Pages: 1293-1299
    |
    Published online on: December 1, 2002
       https://doi.org/10.3892/ijo.21.6.1293
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Abstract

The DNA topoisomerase I inhibitor β-lapachone, the product of a tree from South America, is known to exhibit various biological properties, the mechanisms of which are poorly understood. We investigated the effects of β-lapachone on the growth of human prostate epithelial cells. Upon treatment with β-lapachone, a concentration-dependent inhibition of cell viability was observed and cells developed many of the hallmark features of apoptosis, including condensation of chromatin and DNA fragmentation. The apoptotic effects of β-lapachone were associated with marked induction of p53 phosphorylation and Bax protein without altering the expression of p53 and Bcl-2 protein. In addition, the proteolytic cleavage of specific target proteins such as poly(ADP-ribose) polymerase, β-catenin and Rad51, which are hallmarks of apoptosis, were observed, and Western blotting demonstrated that processing/activation of caspases release cytochrome c from the mitochondria into the cytosol and accompany the generation of β-lapachone-mediating apoptotic cell death. However, β-lapachone did not affect the levels of c-IAP family proteins. The present results suggest that apoptotic signals evoked by β-lapachone in human prostate epithelial cells may converge caspases activation through up-regulation of phosphorylation of p53 and Bax rather than down-regulation of c-IAPs family.

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Copy and paste a formatted citation
Spandidos Publications style
Choi YH, Kim MJ, Lee SY, Lee Y, Chi GY, Eom HS, Kim ND and Choi BT: Phosphorylation of p53, induction of Bax and activation of caspases during β-lapachone-mediated apoptosis in human prostate epithelial cells. Int J Oncol 21: 1293-1299, 2002.
APA
Choi, Y.H., Kim, M.J., Lee, S.Y., Lee, Y., Chi, G.Y., Eom, H.S. ... Choi, B.T. (2002). Phosphorylation of p53, induction of Bax and activation of caspases during β-lapachone-mediated apoptosis in human prostate epithelial cells. International Journal of Oncology, 21, 1293-1299. https://doi.org/10.3892/ijo.21.6.1293
MLA
Choi, Y. H., Kim, M. J., Lee, S. Y., Lee, Y., Chi, G. Y., Eom, H. S., Kim, N. D., Choi, B. T."Phosphorylation of p53, induction of Bax and activation of caspases during β-lapachone-mediated apoptosis in human prostate epithelial cells". International Journal of Oncology 21.6 (2002): 1293-1299.
Chicago
Choi, Y. H., Kim, M. J., Lee, S. Y., Lee, Y., Chi, G. Y., Eom, H. S., Kim, N. D., Choi, B. T."Phosphorylation of p53, induction of Bax and activation of caspases during β-lapachone-mediated apoptosis in human prostate epithelial cells". International Journal of Oncology 21, no. 6 (2002): 1293-1299. https://doi.org/10.3892/ijo.21.6.1293
Copy and paste a formatted citation
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Spandidos Publications style
Choi YH, Kim MJ, Lee SY, Lee Y, Chi GY, Eom HS, Kim ND and Choi BT: Phosphorylation of p53, induction of Bax and activation of caspases during β-lapachone-mediated apoptosis in human prostate epithelial cells. Int J Oncol 21: 1293-1299, 2002.
APA
Choi, Y.H., Kim, M.J., Lee, S.Y., Lee, Y., Chi, G.Y., Eom, H.S. ... Choi, B.T. (2002). Phosphorylation of p53, induction of Bax and activation of caspases during β-lapachone-mediated apoptosis in human prostate epithelial cells. International Journal of Oncology, 21, 1293-1299. https://doi.org/10.3892/ijo.21.6.1293
MLA
Choi, Y. H., Kim, M. J., Lee, S. Y., Lee, Y., Chi, G. Y., Eom, H. S., Kim, N. D., Choi, B. T."Phosphorylation of p53, induction of Bax and activation of caspases during β-lapachone-mediated apoptosis in human prostate epithelial cells". International Journal of Oncology 21.6 (2002): 1293-1299.
Chicago
Choi, Y. H., Kim, M. J., Lee, S. Y., Lee, Y., Chi, G. Y., Eom, H. S., Kim, N. D., Choi, B. T."Phosphorylation of p53, induction of Bax and activation of caspases during β-lapachone-mediated apoptosis in human prostate epithelial cells". International Journal of Oncology 21, no. 6 (2002): 1293-1299. https://doi.org/10.3892/ijo.21.6.1293
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