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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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February 2003 Volume 22 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2003 Volume 22 Issue 2

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Article

Induction of caspase-dependent and -independent apoptosis in response to methionine restriction

  • Authors:
    • Shan Lu
    • Sara M. Hoestje
    • Eugene Choo
    • Daniel E. Epner

  • View Affiliations / Copyright

    Affiliations: Department of Medicine, Baylor College of Medicine and VA Medical Center, Houston, TX 77030, USA
  • Pages: 415-420
    |
    Published online on: February 1, 2003
       https://doi.org/10.3892/ijo.22.2.415
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Abstract

Tumor cells are more sensitive to methionine restriction than normal tissues, a phenomenon known as methionine auxotrophy. Previous studies have demonstrated that methionine restriction causes tumor cell growth arrest and eventually apoptosis. The current studies were undertaken to elucidate the molecular pathways leading to apoptosis induced by methionine restriction. We found that methionine restriction induced formation of oligonucleosomal DNA fragment and cytochrome c release from mitochondria in methionine-dependent PC3 and Hela cells. Methionine restriction also led to cleavage and activation of initiator and effector caspases in Hela cells but not PC3 cells. Furthermore, methionine restriction resulted in cleavage of BID and reduction in Bcl-2 levels in both cell lines. These data suggest that apoptosis induced by methionine restriction is mitochondria-dependent. Methionine restriction induced caspase-independent cell death in PC3 cells, whereas it stimulated caspase-dependent cell death in Hela cells. Cleavage of BID and decreased expression of Bcl-2 upon methionine deprivation may be the underlying mechanism to stimulate release of cytochrome c from mitochondria.

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Copy and paste a formatted citation
Spandidos Publications style
Lu S, Hoestje SM, Choo E and Epner DE: Induction of caspase-dependent and -independent apoptosis in response to methionine restriction. Int J Oncol 22: 415-420, 2003.
APA
Lu, S., Hoestje, S.M., Choo, E., & Epner, D.E. (2003). Induction of caspase-dependent and -independent apoptosis in response to methionine restriction. International Journal of Oncology, 22, 415-420. https://doi.org/10.3892/ijo.22.2.415
MLA
Lu, S., Hoestje, S. M., Choo, E., Epner, D. E."Induction of caspase-dependent and -independent apoptosis in response to methionine restriction". International Journal of Oncology 22.2 (2003): 415-420.
Chicago
Lu, S., Hoestje, S. M., Choo, E., Epner, D. E."Induction of caspase-dependent and -independent apoptosis in response to methionine restriction". International Journal of Oncology 22, no. 2 (2003): 415-420. https://doi.org/10.3892/ijo.22.2.415
Copy and paste a formatted citation
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Spandidos Publications style
Lu S, Hoestje SM, Choo E and Epner DE: Induction of caspase-dependent and -independent apoptosis in response to methionine restriction. Int J Oncol 22: 415-420, 2003.
APA
Lu, S., Hoestje, S.M., Choo, E., & Epner, D.E. (2003). Induction of caspase-dependent and -independent apoptosis in response to methionine restriction. International Journal of Oncology, 22, 415-420. https://doi.org/10.3892/ijo.22.2.415
MLA
Lu, S., Hoestje, S. M., Choo, E., Epner, D. E."Induction of caspase-dependent and -independent apoptosis in response to methionine restriction". International Journal of Oncology 22.2 (2003): 415-420.
Chicago
Lu, S., Hoestje, S. M., Choo, E., Epner, D. E."Induction of caspase-dependent and -independent apoptosis in response to methionine restriction". International Journal of Oncology 22, no. 2 (2003): 415-420. https://doi.org/10.3892/ijo.22.2.415
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