Genome-wide cDNA microarray analysis of gene-expression profiles involved in ovarian endometriosis

Arimoto,Takahide; Katagiri,Toyomasa; Oda,Katsutoshi; Tsunoda,Tatsuhiko; Yasugi,Toshiharu; Osuga,Yutaka; Yoshikawa,Hiroyuki; Nishii,Osamu; Yano,Tetsu; Taketani,Yuji; Nakamura,Yusuke

doi:10.3892/ijo.22.3.551

March 2003 Volume 22 Issue 3

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March 2003 Volume 22 Issue 3

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Article

Genome-wide cDNA microarray analysis of gene-expression profiles involved in ovarian endometriosis

Authors:
- Takahide Arimoto
- Toyomasa Katagiri
- Katsutoshi Oda
- Tatsuhiko Tsunoda
- Toshiharu Yasugi
- Yutaka Osuga
- Hiroyuki Yoshikawa
- Osamu Nishii
- Tetsu Yano
- Yuji Taketani
- Yusuke Nakamura
View Affiliations / Copyright

Affiliations: Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan
Pages: 551-560
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Published online on: March 1, 2003

https://doi.org/10.3892/ijo.22.3.551
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Abstract

Using a cDNA microarray consisting of 23,040 genes, we analyzed gene-expression profiles of ovarian endometrial cysts from 23 patients in order to identify genes involved in endometriosis. By comparing expression patterns between endometriotic tissues and corresponding eutopic endometria, we identified 15 genes that were commonly up-regulated in the endometrial cysts during both proliferative and secretory phases of the menstrual cycle, 42 that were up-regulated only in the proliferative phase, and 40 that were up-regulated only in the secretory phase. The up-regulated elements included genes encoding some HLA antigens, complement factors, ribosomal proteins, and TGFBI. On the other hand, 337 genes were commonly down-regulated throughout the menstrual cycle, 144 only in the proliferative phase, and 835 only in the secretory phase. The down-regulated elements included the tumor suppressor TP53, genes related to apoptosis such as GADD34, GADD45A, GADD45B and PIG11, and the gene encoding OVGP1, a protein involved in maintenance of early pregnancy. Semi-quantitative RT-PCR experiments supported the results of our microarray analysis. These data should provide useful information for finding candidate genes whose products might serve as molecular targets for diagnosis or treatment of endometriosis.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Genome-wide cDNA microarray analysis of gene-expression profiles involved in ovarian endometriosis

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