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Participation of fibroblasts in MMP-2 binding and activation on the surface of oral squamous cell carcinoma cells

  • Authors:
    • Yasutaka Hayashido
    • Kazuhiko Urabe
    • Yukio Yoshioka
    • Hisataka Kitano
    • Tetsuji Okamoto
    • Tokuzo Matsuya

  • View Affiliations

  • Published online on: March 1, 2003     https://doi.org/10.3892/ijo.22.3.657
  • Pages: 657-662
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Abstract

The effect of fibroblasts on the activation of matrix metalloproteinase-2 (MMP-2) in oral squamous cell carcinoma (SCC) cells was examined. The plasma membrane of SCC cells failed to bind and activate latent MMP-2. However, treatment of SCC cells with fibroblast-conditioned medium (fibroblast-CM) led to the enhancement of the binding and activation of latent MMP-2 on the cell surface. Moreover, fibroblasts induced the expression of membrane type 1 MMP (MT1-MMP) in SCC cells. MMP-2 activated on the cell surface bound to the surface of SCC cells via αv integrins. These findings suggest that fibroblasts might facilitate the invasion of SCC cells by increasing the proteolytic activity on the surfaces of SCC cells.

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Journal Cover

March 2003
Volume 22 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Journal Metrics
  • Impact Factor: 5.2
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 11.4
  • CiteScore Rank: Q1: #40/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 1.125
  • SCImago Journal Rank (SJR): 1.105
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Spandidos Publications style
Hayashido Y, Urabe K, Yoshioka Y, Kitano H, Okamoto T and Matsuya T: Participation of fibroblasts in MMP-2 binding and activation on the surface of oral squamous cell carcinoma cells. Int J Oncol 22: 657-662, 2003
APA
Hayashido, Y., Urabe, K., Yoshioka, Y., Kitano, H., Okamoto, T., & Matsuya, T. (2003). Participation of fibroblasts in MMP-2 binding and activation on the surface of oral squamous cell carcinoma cells. International Journal of Oncology, 22, 657-662. https://doi.org/10.3892/ijo.22.3.657
MLA
Hayashido, Y., Urabe, K., Yoshioka, Y., Kitano, H., Okamoto, T., Matsuya, T."Participation of fibroblasts in MMP-2 binding and activation on the surface of oral squamous cell carcinoma cells". International Journal of Oncology 22.3 (2003): 657-662.
Chicago
Hayashido, Y., Urabe, K., Yoshioka, Y., Kitano, H., Okamoto, T., Matsuya, T."Participation of fibroblasts in MMP-2 binding and activation on the surface of oral squamous cell carcinoma cells". International Journal of Oncology 22, no. 3 (2003): 657-662. https://doi.org/10.3892/ijo.22.3.657