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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April 2003 Volume 22 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April 2003 Volume 22 Issue 4

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Article

Splicing variant ΔVII-Ets1 is downregulated in invasive Ets1-expressing breast cancer cells

  • Authors:
    • Pia Ballschmieter
    • Melanie Braig
    • Ralph K. Lindemann
    • Alfred Nordheim
    • Jürgen Dittmer

  • View Affiliations / Copyright

    Affiliations: Friedrich Miescher Institut, 4058 Basel, Switzerland
  • Pages: 849-853
    |
    Published online on: April 1, 2003
       https://doi.org/10.3892/ijo.22.4.849
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Abstract

Transcription factor Ets1 is expressed in invasive breast cancer cells. In T-cells, the splicing variant ΔVII-Ets1 is naturally produced along with full length Ets1 (fl-Ets1). Though its function is unknown, the lack of important inhibitory domains predicts a regulatory role of ΔVII-Ets1 in fl-Ets1-controlled transcription. Examining the expression status of ΔVII-Ets1 in invasive Ets1-producing MDA-MB-231 breast cancer cells, we found that the ΔVII-Ets1 protein could only be detected when nuclear proteins from these cells were fractionated by ionic exchange chromatography. When overexpressed, ΔVII-Ets1 was found to be partially degraded in breast cancer cells, but not in Jurkat T-cells or SK-Mel melanoma cells. In contrast, no proteolytic products resulted from ectopic expression of fl-Ets1 suggesting that breast cancer cells are able to specifically cleave ΔVII-Ets1. Overexpression of ΔVII-Ets1 reduced survival of MDA-MB-231 cells, but not of MCF-7 cells. A mutant version of ΔVII-Ets1, lacking first 129 N-terminal amino acids, had no effect. These data suggest that Ets1-producing invasive breast cancer cells specifically downregulate ΔVII-Ets1, as it may be able to adversely affect the survival of these cells.

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Copy and paste a formatted citation
Spandidos Publications style
Ballschmieter P, Braig M, Lindemann RK, Nordheim A and Dittmer J: Splicing variant ΔVII-Ets1 is downregulated in invasive Ets1-expressing breast cancer cells. Int J Oncol 22: 849-853, 2003.
APA
Ballschmieter, P., Braig, M., Lindemann, R.K., Nordheim, A., & Dittmer, J. (2003). Splicing variant ΔVII-Ets1 is downregulated in invasive Ets1-expressing breast cancer cells. International Journal of Oncology, 22, 849-853. https://doi.org/10.3892/ijo.22.4.849
MLA
Ballschmieter, P., Braig, M., Lindemann, R. K., Nordheim, A., Dittmer, J."Splicing variant ΔVII-Ets1 is downregulated in invasive Ets1-expressing breast cancer cells". International Journal of Oncology 22.4 (2003): 849-853.
Chicago
Ballschmieter, P., Braig, M., Lindemann, R. K., Nordheim, A., Dittmer, J."Splicing variant ΔVII-Ets1 is downregulated in invasive Ets1-expressing breast cancer cells". International Journal of Oncology 22, no. 4 (2003): 849-853. https://doi.org/10.3892/ijo.22.4.849
Copy and paste a formatted citation
x
Spandidos Publications style
Ballschmieter P, Braig M, Lindemann RK, Nordheim A and Dittmer J: Splicing variant ΔVII-Ets1 is downregulated in invasive Ets1-expressing breast cancer cells. Int J Oncol 22: 849-853, 2003.
APA
Ballschmieter, P., Braig, M., Lindemann, R.K., Nordheim, A., & Dittmer, J. (2003). Splicing variant ΔVII-Ets1 is downregulated in invasive Ets1-expressing breast cancer cells. International Journal of Oncology, 22, 849-853. https://doi.org/10.3892/ijo.22.4.849
MLA
Ballschmieter, P., Braig, M., Lindemann, R. K., Nordheim, A., Dittmer, J."Splicing variant ΔVII-Ets1 is downregulated in invasive Ets1-expressing breast cancer cells". International Journal of Oncology 22.4 (2003): 849-853.
Chicago
Ballschmieter, P., Braig, M., Lindemann, R. K., Nordheim, A., Dittmer, J."Splicing variant ΔVII-Ets1 is downregulated in invasive Ets1-expressing breast cancer cells". International Journal of Oncology 22, no. 4 (2003): 849-853. https://doi.org/10.3892/ijo.22.4.849
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