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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April 2003 Volume 22 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April 2003 Volume 22 Issue 4

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Article

The effect of bone-associated growth factors and cytokines on the growth of prostate cancer cells derived from soft tissue versus bone metastases in vitro

  • Authors:
    • Hyung-Lae Lee
    • Kenneth J. Pienta
    • Wun-Jae Kim
    • Carlton R. Cooper

  • View Affiliations / Copyright

    Affiliations: Chungbuk National University, Cheongju, Korea
  • Pages: 921-926
    |
    Published online on: April 1, 2003
       https://doi.org/10.3892/ijo.22.4.921
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Abstract

Prostate cancer metastasis to bone may be mediated by preferential proliferation of these cells in the bone's microenvironment. We hypothesize that this preferential proliferation is mediated by bone-associated growth factors (GFs) and cytokines. To test our hypothesis, human prostate cancer cells, derived from both soft tissue (LNCaP, DuCaP, DU145) and bone metastases (PC-3, VCaP, MDA-2a, MDA-2b), were treated with bone-associated GFs and cytokines (PDGF, IGF-1, TGF-β, EGF, bFGF, TNF-α, IL-1, and IL-6) for 48 h, and their growth responses were compared. The responses of soft tissue-derived prostate cancer cell lines to bone GFs and cytokines were variable. LNCaP cell growth was stimulated by IGF-1 but was inhibited by TNF-α. DU145 cell growth was stimulated with EGF. Prostate cancer cell lines derived from bone metastases also responded variably to bone GFs and cytokines. IL-1 stimulated the growth of MDA-2a and 2b cell lines in a dose-dependent manner. PDGF and bFGF both demonstrated variable effects on bone-derived prostate cancer cell lines. TNF-α inhibited proliferation of the VCaP cells. These findings demonstrate that human prostate cancer cell lines derived from bone metastases may not respond preferentially to bone-associated GFs and cytokines.

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Copy and paste a formatted citation
Spandidos Publications style
Lee H, Pienta KJ, Kim W and Cooper CR: The effect of bone-associated growth factors and cytokines on the growth of prostate cancer cells derived from soft tissue versus bone metastases in vitro. Int J Oncol 22: 921-926, 2003.
APA
Lee, H., Pienta, K.J., Kim, W., & Cooper, C.R. (2003). The effect of bone-associated growth factors and cytokines on the growth of prostate cancer cells derived from soft tissue versus bone metastases in vitro. International Journal of Oncology, 22, 921-926. https://doi.org/10.3892/ijo.22.4.921
MLA
Lee, H., Pienta, K. J., Kim, W., Cooper, C. R."The effect of bone-associated growth factors and cytokines on the growth of prostate cancer cells derived from soft tissue versus bone metastases in vitro". International Journal of Oncology 22.4 (2003): 921-926.
Chicago
Lee, H., Pienta, K. J., Kim, W., Cooper, C. R."The effect of bone-associated growth factors and cytokines on the growth of prostate cancer cells derived from soft tissue versus bone metastases in vitro". International Journal of Oncology 22, no. 4 (2003): 921-926. https://doi.org/10.3892/ijo.22.4.921
Copy and paste a formatted citation
x
Spandidos Publications style
Lee H, Pienta KJ, Kim W and Cooper CR: The effect of bone-associated growth factors and cytokines on the growth of prostate cancer cells derived from soft tissue versus bone metastases in vitro. Int J Oncol 22: 921-926, 2003.
APA
Lee, H., Pienta, K.J., Kim, W., & Cooper, C.R. (2003). The effect of bone-associated growth factors and cytokines on the growth of prostate cancer cells derived from soft tissue versus bone metastases in vitro. International Journal of Oncology, 22, 921-926. https://doi.org/10.3892/ijo.22.4.921
MLA
Lee, H., Pienta, K. J., Kim, W., Cooper, C. R."The effect of bone-associated growth factors and cytokines on the growth of prostate cancer cells derived from soft tissue versus bone metastases in vitro". International Journal of Oncology 22.4 (2003): 921-926.
Chicago
Lee, H., Pienta, K. J., Kim, W., Cooper, C. R."The effect of bone-associated growth factors and cytokines on the growth of prostate cancer cells derived from soft tissue versus bone metastases in vitro". International Journal of Oncology 22, no. 4 (2003): 921-926. https://doi.org/10.3892/ijo.22.4.921
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