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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 2003 Volume 22 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2003 Volume 22 Issue 6

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Article

Identification of a novel human gene, ZFP91, involved in acute myelogenous leukemia

  • Authors:
    • Motoko Unoki
    • Junichi Okutsu
    • Yusuke Nakamura

  • View Affiliations / Copyright

    Affiliations: Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan
  • Pages: 1217-1223
    |
    Published online on: June 1, 2003
       https://doi.org/10.3892/ijo.22.6.1217
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Abstract

To elucidate mechanisms leading to acute myelogenous leukemia (AML), to find sensitive markers and novel targets for drug therapy, and to allow choice of suitable chemotherapy for each affected individual, we previously compared expression of mRNA from mononuclear cells of AML patients with that of normal controls using a cDNA microarray. Data from that study identified many genes that were commonly up- or down-regulated in AML cells. Of these, we report here the identification of a novel gene whose expression was increased in 27 (93%) of the 29 AML cases whose PBMC preparations include >70% leukemia cells. The gene product, localized in nuclei, showed several characteristics of transcription factors: five zinc-finger domains, a leucine zipper, and several nuclear localization signals. Its 92.5% identity in amino-acid sequence to the murine penta zinc finger protein (mPZf; gene symbol Zfp91), led us to term it ZFP91. Anti-sense oligonucleotides inhibited expression of ZFP91, suppressed cell growth, and induced apoptosis. Our results suggest that ZFP91 is likely to play an important role in cell proliferation and/or anti-apoptosis, and may serve as a molecular marker for AML.

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Copy and paste a formatted citation
Spandidos Publications style
Unoki M, Okutsu J and Nakamura Y: Identification of a novel human gene, ZFP91, involved in acute myelogenous leukemia. Int J Oncol 22: 1217-1223, 2003.
APA
Unoki, M., Okutsu, J., & Nakamura, Y. (2003). Identification of a novel human gene, ZFP91, involved in acute myelogenous leukemia. International Journal of Oncology, 22, 1217-1223. https://doi.org/10.3892/ijo.22.6.1217
MLA
Unoki, M., Okutsu, J., Nakamura, Y."Identification of a novel human gene, ZFP91, involved in acute myelogenous leukemia". International Journal of Oncology 22.6 (2003): 1217-1223.
Chicago
Unoki, M., Okutsu, J., Nakamura, Y."Identification of a novel human gene, ZFP91, involved in acute myelogenous leukemia". International Journal of Oncology 22, no. 6 (2003): 1217-1223. https://doi.org/10.3892/ijo.22.6.1217
Copy and paste a formatted citation
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Spandidos Publications style
Unoki M, Okutsu J and Nakamura Y: Identification of a novel human gene, ZFP91, involved in acute myelogenous leukemia. Int J Oncol 22: 1217-1223, 2003.
APA
Unoki, M., Okutsu, J., & Nakamura, Y. (2003). Identification of a novel human gene, ZFP91, involved in acute myelogenous leukemia. International Journal of Oncology, 22, 1217-1223. https://doi.org/10.3892/ijo.22.6.1217
MLA
Unoki, M., Okutsu, J., Nakamura, Y."Identification of a novel human gene, ZFP91, involved in acute myelogenous leukemia". International Journal of Oncology 22.6 (2003): 1217-1223.
Chicago
Unoki, M., Okutsu, J., Nakamura, Y."Identification of a novel human gene, ZFP91, involved in acute myelogenous leukemia". International Journal of Oncology 22, no. 6 (2003): 1217-1223. https://doi.org/10.3892/ijo.22.6.1217
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