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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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August 2003 Volume 23 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2003 Volume 23 Issue 2

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Article

Introductory experiments on ligand liposomes as delivery agents for boron neutron capture therapy

  • Authors:
    • Erika Bohl Kullberg
    • Jörgen Carlsson
    • Katarina Edwards
    • Jacek Capala
    • Stefan Sjöberg
    • Lars Gedda

  • View Affiliations / Copyright

    Affiliations: Division of Biomedical Radiation Sciences, Rudbeck Laboratory, Uppsala University, 75185 Uppsala, Sweden. Erika Bohl@bms.uu.se
  • Pages: 461-467
    |
    Published online on: August 1, 2003
       https://doi.org/10.3892/ijo.23.2.461
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Abstract

Liposomes are, when coupled to receptor ligands, candidates for receptor mediated delivery of boron for tumour therapy since they have capacity to deliver large amounts of boron per receptor interaction. With EGF-liposomes we present a pegylated ligand liposome delivery vehicle, containing water soluble boronated phenanthridine, WSP1, or water soluble boronated acridine, WSA1, for EGFR targeting. In the case of WSA1 a ligand dependent uptake was obtained and the boron uptake was as good as if free WSA1 was given. No ligand dependent boron uptake was seen for WSP1 containing liposomes. Thus, WSA1 is a candidate for further studies. Approximately 105 boron atoms were in each liposome. A critical assessment indicates that after optimization up to 106 boron atoms can be loaded. Since it is known that, for therapeutic effect, approximately 108-109 boron atoms are needed in a single tumour cell it is realized that 102-103 receptor interactions are needed to meet the demand. Tests applying cultured glioma cells indicate, without optimization of the delivery conditions, a boron uptake in the ppm range, which is necessary for successful BNCT. Thus, it seems possible to kill micro-invasive tumour cells with targeted liposomes if the delivery conditions are optimal.

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Copy and paste a formatted citation
Spandidos Publications style
Bohl Kullberg E, Carlsson J, Edwards K, Capala J, Sjöberg S and Gedda L: Introductory experiments on ligand liposomes as delivery agents for boron neutron capture therapy. Int J Oncol 23: 461-467, 2003.
APA
Bohl Kullberg, E., Carlsson, J., Edwards, K., Capala, J., Sjöberg, S., & Gedda, L. (2003). Introductory experiments on ligand liposomes as delivery agents for boron neutron capture therapy. International Journal of Oncology, 23, 461-467. https://doi.org/10.3892/ijo.23.2.461
MLA
Bohl Kullberg, E., Carlsson, J., Edwards, K., Capala, J., Sjöberg, S., Gedda, L."Introductory experiments on ligand liposomes as delivery agents for boron neutron capture therapy". International Journal of Oncology 23.2 (2003): 461-467.
Chicago
Bohl Kullberg, E., Carlsson, J., Edwards, K., Capala, J., Sjöberg, S., Gedda, L."Introductory experiments on ligand liposomes as delivery agents for boron neutron capture therapy". International Journal of Oncology 23, no. 2 (2003): 461-467. https://doi.org/10.3892/ijo.23.2.461
Copy and paste a formatted citation
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Spandidos Publications style
Bohl Kullberg E, Carlsson J, Edwards K, Capala J, Sjöberg S and Gedda L: Introductory experiments on ligand liposomes as delivery agents for boron neutron capture therapy. Int J Oncol 23: 461-467, 2003.
APA
Bohl Kullberg, E., Carlsson, J., Edwards, K., Capala, J., Sjöberg, S., & Gedda, L. (2003). Introductory experiments on ligand liposomes as delivery agents for boron neutron capture therapy. International Journal of Oncology, 23, 461-467. https://doi.org/10.3892/ijo.23.2.461
MLA
Bohl Kullberg, E., Carlsson, J., Edwards, K., Capala, J., Sjöberg, S., Gedda, L."Introductory experiments on ligand liposomes as delivery agents for boron neutron capture therapy". International Journal of Oncology 23.2 (2003): 461-467.
Chicago
Bohl Kullberg, E., Carlsson, J., Edwards, K., Capala, J., Sjöberg, S., Gedda, L."Introductory experiments on ligand liposomes as delivery agents for boron neutron capture therapy". International Journal of Oncology 23, no. 2 (2003): 461-467. https://doi.org/10.3892/ijo.23.2.461
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