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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 2003 Volume 23 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2003 Volume 23 Issue 5

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Article

Bystander effect in suicide gene therapy is directly proportional to the degree of gap junctional intercellular communication in esophageal cancer

  • Authors:
    • Satoru Matono
    • Toshiaki Tanaka
    • Susumu Sueyoshi
    • Hideaki Yamana
    • Hiromasa Fujita
    • Kazuo Shirouzu

  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Kurume University School of Medicine, Kurume-shi 830-0011, Japan
  • Pages: 1309-1315
    |
    Published online on: November 1, 2003
       https://doi.org/10.3892/ijo.23.5.1309
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Abstract

Gap junctional intercellular communication (GJIC) has been shown to be involved in the bystander effect through herpes simplex virus thymidine kinase/ganciclovir (HSV-tk/GCV) gene therapy. In this study, we examined the expression of connexins, the components of gap junction, and the degree of GJIC in esophageal cancer cell lines and compared the bystander effect in cells with different capacities of GJIC. We found loss in connexin 26 expression and reduced connexin 43 in esophageal cancer. GJIC capacity varied among cell lines and was dependent on the connexin 43 expression in the cell-cell contact areas. In mixing assay, the extent of the bystander effect was tightly correlated with the degree of GJIC capacity. The effects of retinoic acid and cAMP on the bystander effect were also investigated. Treatment with retinoic acid, but not with cAMP, was associated with augmented bystander killing by increase in GJIC in some esophageal cancer cell lines. Our results indicated that the degree of GJIC was predictive to identify a tumor as suitable for gene therapy with the HSV-tk/GCV system. Also GJIC chemically-enhanced with retinoic acid might be useful to improve response in suicide gene therapy.

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Copy and paste a formatted citation
Spandidos Publications style
Matono S, Tanaka T, Sueyoshi S, Yamana H, Fujita H and Shirouzu K: Bystander effect in suicide gene therapy is directly proportional to the degree of gap junctional intercellular communication in esophageal cancer. Int J Oncol 23: 1309-1315, 2003.
APA
Matono, S., Tanaka, T., Sueyoshi, S., Yamana, H., Fujita, H., & Shirouzu, K. (2003). Bystander effect in suicide gene therapy is directly proportional to the degree of gap junctional intercellular communication in esophageal cancer. International Journal of Oncology, 23, 1309-1315. https://doi.org/10.3892/ijo.23.5.1309
MLA
Matono, S., Tanaka, T., Sueyoshi, S., Yamana, H., Fujita, H., Shirouzu, K."Bystander effect in suicide gene therapy is directly proportional to the degree of gap junctional intercellular communication in esophageal cancer". International Journal of Oncology 23.5 (2003): 1309-1315.
Chicago
Matono, S., Tanaka, T., Sueyoshi, S., Yamana, H., Fujita, H., Shirouzu, K."Bystander effect in suicide gene therapy is directly proportional to the degree of gap junctional intercellular communication in esophageal cancer". International Journal of Oncology 23, no. 5 (2003): 1309-1315. https://doi.org/10.3892/ijo.23.5.1309
Copy and paste a formatted citation
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Spandidos Publications style
Matono S, Tanaka T, Sueyoshi S, Yamana H, Fujita H and Shirouzu K: Bystander effect in suicide gene therapy is directly proportional to the degree of gap junctional intercellular communication in esophageal cancer. Int J Oncol 23: 1309-1315, 2003.
APA
Matono, S., Tanaka, T., Sueyoshi, S., Yamana, H., Fujita, H., & Shirouzu, K. (2003). Bystander effect in suicide gene therapy is directly proportional to the degree of gap junctional intercellular communication in esophageal cancer. International Journal of Oncology, 23, 1309-1315. https://doi.org/10.3892/ijo.23.5.1309
MLA
Matono, S., Tanaka, T., Sueyoshi, S., Yamana, H., Fujita, H., Shirouzu, K."Bystander effect in suicide gene therapy is directly proportional to the degree of gap junctional intercellular communication in esophageal cancer". International Journal of Oncology 23.5 (2003): 1309-1315.
Chicago
Matono, S., Tanaka, T., Sueyoshi, S., Yamana, H., Fujita, H., Shirouzu, K."Bystander effect in suicide gene therapy is directly proportional to the degree of gap junctional intercellular communication in esophageal cancer". International Journal of Oncology 23, no. 5 (2003): 1309-1315. https://doi.org/10.3892/ijo.23.5.1309
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