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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 2003 Volume 23 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2003 Volume 23 Issue 5

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Article

HER2 testing in gastric cancer: Molecular morphology and storage time-related changes in archival samples

  • Authors:
    • Mauro Risio
    • Giovanni De Rosa
    • Ivana Sarotto
    • Laura Casorzo
    • Lorenzo Capussotti
    • Bruno Torchio
    • Massimo Aglietta
    • Laura Chiecchio

  • View Affiliations / Copyright

    Affiliations: Unit of Pathology, Institute for Cancer Research and Treatment (I.R.C.C.), Km. 3.95, I-10060 Candiolo-Torino, Italy. mrisio@mauriziano.it
  • Pages: 1381-1387
    |
    Published online on: November 1, 2003
       https://doi.org/10.3892/ijo.23.5.1381
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Abstract

Seventy-two archival specimens of advanced gastric adenocarcinoma were analyzed by fluorescence in situ hybridization and immunohistochemistry for HER2 gene status. Gene amplification and concomitant protein overexpression were detected in 15.2% of cases. Intratumor topographical variability of HER2 amplification was observed, indicative of the late involvement of HER gene in gastric tumorigenesis. No significant correlations were found between HER2 status and histopathologic type, grade of differentiation, and Goseki classification of carcinomas, suggesting that HER2 gene is variably linked with the morphogenesis of gastric adenocarcinoma. A significant decrease of the incidence of HER2 amplified carcinomas in function of the duration of the storage of paraffin blocks was observed: 42-33% for tumor specimens paraffin-embedded in 2002-2001; 8.3%, 15.7%, 11.1% for the years 2000, 1999, 1998, respectively; 0% for cases embedded during 1997. According to these results, the reliability of the FISH and immunohistochemical assays decreases after prolonged storage of paraffin-embedded specimens.

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Copy and paste a formatted citation
Spandidos Publications style
Risio M, De Rosa G, Sarotto I, Casorzo L, Capussotti L, Torchio B, Aglietta M and Chiecchio L: HER2 testing in gastric cancer: Molecular morphology and storage time-related changes in archival samples. Int J Oncol 23: 1381-1387, 2003.
APA
Risio, M., De Rosa, G., Sarotto, I., Casorzo, L., Capussotti, L., Torchio, B. ... Chiecchio, L. (2003). HER2 testing in gastric cancer: Molecular morphology and storage time-related changes in archival samples. International Journal of Oncology, 23, 1381-1387. https://doi.org/10.3892/ijo.23.5.1381
MLA
Risio, M., De Rosa, G., Sarotto, I., Casorzo, L., Capussotti, L., Torchio, B., Aglietta, M., Chiecchio, L."HER2 testing in gastric cancer: Molecular morphology and storage time-related changes in archival samples". International Journal of Oncology 23.5 (2003): 1381-1387.
Chicago
Risio, M., De Rosa, G., Sarotto, I., Casorzo, L., Capussotti, L., Torchio, B., Aglietta, M., Chiecchio, L."HER2 testing in gastric cancer: Molecular morphology and storage time-related changes in archival samples". International Journal of Oncology 23, no. 5 (2003): 1381-1387. https://doi.org/10.3892/ijo.23.5.1381
Copy and paste a formatted citation
x
Spandidos Publications style
Risio M, De Rosa G, Sarotto I, Casorzo L, Capussotti L, Torchio B, Aglietta M and Chiecchio L: HER2 testing in gastric cancer: Molecular morphology and storage time-related changes in archival samples. Int J Oncol 23: 1381-1387, 2003.
APA
Risio, M., De Rosa, G., Sarotto, I., Casorzo, L., Capussotti, L., Torchio, B. ... Chiecchio, L. (2003). HER2 testing in gastric cancer: Molecular morphology and storage time-related changes in archival samples. International Journal of Oncology, 23, 1381-1387. https://doi.org/10.3892/ijo.23.5.1381
MLA
Risio, M., De Rosa, G., Sarotto, I., Casorzo, L., Capussotti, L., Torchio, B., Aglietta, M., Chiecchio, L."HER2 testing in gastric cancer: Molecular morphology and storage time-related changes in archival samples". International Journal of Oncology 23.5 (2003): 1381-1387.
Chicago
Risio, M., De Rosa, G., Sarotto, I., Casorzo, L., Capussotti, L., Torchio, B., Aglietta, M., Chiecchio, L."HER2 testing in gastric cancer: Molecular morphology and storage time-related changes in archival samples". International Journal of Oncology 23, no. 5 (2003): 1381-1387. https://doi.org/10.3892/ijo.23.5.1381
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