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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 2003 Volume 23 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2003 Volume 23 Issue 5

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Article

Clinical significance of telomerase activity in basal cell carcinomas and in tumour-free surgical margins

  • Authors:
    • Eva-Maria Fabricius
    • Aleksej Bezeluk
    • Ute Kruse-Boitschenko
    • Gustav-Paul Wildner
    • Martin Klein

  • View Affiliations / Copyright

    Affiliations: Medical Faculty of the Humboldt University of Berlin, Charité, Campus Virchow Hospital, Clinic for Oral and Maxillofacial Surgery, D-13353 Berlin, Germany. eva-maria.fabricius@charite.de
  • Pages: 1389-1399
    |
    Published online on: November 1, 2003
       https://doi.org/10.3892/ijo.23.5.1389
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Abstract

To distinguish the infiltrative from the non-infiltrative basal cell carcinoma (BCC), cell cycle markers are being used to supplement histopathological assessment, and proliferation markers are proving particularly useful. A successful radical therapeutic intervention depends on a clear histopathological diagnosis, especially for the tumour margins. For this purpose we investigated whether proof of telomerase activation is a suitable adjunctive molecular marker. We were also interested in the telomerase activity (TA) of BCC-free margin tissues as a prognostic parameter of relapse. Using PCR-ELISA kits, we found TA in 26/30 (87%) BCC tissues and in 8/25 (32%) of the tumour-free surgical margin tissues. Telomerase levels and the incidence of telomerase-positive tumour tissues are not always associated with positive p53 immunoreactive scores in BCC tissues. But telomerase levels correlate significantly with p53 expression levels. In the Kaplan-Meier curve, patients with telomerase-positive tumour-free surgical margin tissues showed significantly shorter relapse-free periods than patients with telomerase-negative tumour-free margin tissues.

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Copy and paste a formatted citation
Spandidos Publications style
Fabricius E, Bezeluk A, Kruse-Boitschenko U, Wildner G and Klein M: Clinical significance of telomerase activity in basal cell carcinomas and in tumour-free surgical margins. Int J Oncol 23: 1389-1399, 2003.
APA
Fabricius, E., Bezeluk, A., Kruse-Boitschenko, U., Wildner, G., & Klein, M. (2003). Clinical significance of telomerase activity in basal cell carcinomas and in tumour-free surgical margins. International Journal of Oncology, 23, 1389-1399. https://doi.org/10.3892/ijo.23.5.1389
MLA
Fabricius, E., Bezeluk, A., Kruse-Boitschenko, U., Wildner, G., Klein, M."Clinical significance of telomerase activity in basal cell carcinomas and in tumour-free surgical margins". International Journal of Oncology 23.5 (2003): 1389-1399.
Chicago
Fabricius, E., Bezeluk, A., Kruse-Boitschenko, U., Wildner, G., Klein, M."Clinical significance of telomerase activity in basal cell carcinomas and in tumour-free surgical margins". International Journal of Oncology 23, no. 5 (2003): 1389-1399. https://doi.org/10.3892/ijo.23.5.1389
Copy and paste a formatted citation
x
Spandidos Publications style
Fabricius E, Bezeluk A, Kruse-Boitschenko U, Wildner G and Klein M: Clinical significance of telomerase activity in basal cell carcinomas and in tumour-free surgical margins. Int J Oncol 23: 1389-1399, 2003.
APA
Fabricius, E., Bezeluk, A., Kruse-Boitschenko, U., Wildner, G., & Klein, M. (2003). Clinical significance of telomerase activity in basal cell carcinomas and in tumour-free surgical margins. International Journal of Oncology, 23, 1389-1399. https://doi.org/10.3892/ijo.23.5.1389
MLA
Fabricius, E., Bezeluk, A., Kruse-Boitschenko, U., Wildner, G., Klein, M."Clinical significance of telomerase activity in basal cell carcinomas and in tumour-free surgical margins". International Journal of Oncology 23.5 (2003): 1389-1399.
Chicago
Fabricius, E., Bezeluk, A., Kruse-Boitschenko, U., Wildner, G., Klein, M."Clinical significance of telomerase activity in basal cell carcinomas and in tumour-free surgical margins". International Journal of Oncology 23, no. 5 (2003): 1389-1399. https://doi.org/10.3892/ijo.23.5.1389
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