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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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January 2004 Volume 24 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2004 Volume 24 Issue 1

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Article

Expression and localization of MUC1, MUC2, MUC5AC and small intestinal mucin antigen in pancreatic tumors

  • Authors:
    • Hiroyuki Yamasaki
    • Satoshi Ikeda
    • Masazumi Okajima
    • Yoshio Miura
    • Toshimasa Asahara
    • Nobuoki Kohno
    • Fumio Shimamoto

  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Minami-ku, Hiroshima 734-8551, Japan
  • Pages: 107-113
    |
    Published online on: January 1, 2004
       https://doi.org/10.3892/ijo.24.1.107
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Abstract

Alterations in the expression of mucin family members play an important role as well as alterations in oncogenes and onco-suppressor genes in carcinogenesis and progression of pancreatic cancer. We analyzed the expression and localization of MUC1, MUC2, MUC5AC and small intestinal mucin antigen (SIMA) in pancreatic tumors. MUC1 expression was observed in almost all samples, whereas MUC2 expression was not. MUC5AC expression was observed in 73.9% of the cancerous regions, 48.7% of the dysplastic regions and 72.0% of the hyperplastic regions but not in the normal pancreatic duct. SIMA expression was observed in 45.7% of cancerous regions, 17.9% of the dysplastic regions and 8.0% of the hyperplastic regions. Furthermore, stromal expression of MUC1, MUC5AC and SIMA was observed in 37.0%, 60.9% and 26.1% of the cancerous regions, respectively. Stromal expression of these mucins was not observed in the hyperplastic regions and normal pancreatic duct and was observed in only two dysplastic regions. The survival of pancreatic cancer patients with stromal expression of MUC1 or SIMA was worse than that of other patients (P=0.04). In conclusion, the localization of mucin expression, especially stromal expression of MUC1 or SIMA, might be a prognostic factor for patients with pancreatic cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Yamasaki H, Ikeda S, Okajima M, Miura Y, Asahara T, Kohno N and Shimamoto F: Expression and localization of MUC1, MUC2, MUC5AC and small intestinal mucin antigen in pancreatic tumors. Int J Oncol 24: 107-113, 2004.
APA
Yamasaki, H., Ikeda, S., Okajima, M., Miura, Y., Asahara, T., Kohno, N., & Shimamoto, F. (2004). Expression and localization of MUC1, MUC2, MUC5AC and small intestinal mucin antigen in pancreatic tumors. International Journal of Oncology, 24, 107-113. https://doi.org/10.3892/ijo.24.1.107
MLA
Yamasaki, H., Ikeda, S., Okajima, M., Miura, Y., Asahara, T., Kohno, N., Shimamoto, F."Expression and localization of MUC1, MUC2, MUC5AC and small intestinal mucin antigen in pancreatic tumors". International Journal of Oncology 24.1 (2004): 107-113.
Chicago
Yamasaki, H., Ikeda, S., Okajima, M., Miura, Y., Asahara, T., Kohno, N., Shimamoto, F."Expression and localization of MUC1, MUC2, MUC5AC and small intestinal mucin antigen in pancreatic tumors". International Journal of Oncology 24, no. 1 (2004): 107-113. https://doi.org/10.3892/ijo.24.1.107
Copy and paste a formatted citation
x
Spandidos Publications style
Yamasaki H, Ikeda S, Okajima M, Miura Y, Asahara T, Kohno N and Shimamoto F: Expression and localization of MUC1, MUC2, MUC5AC and small intestinal mucin antigen in pancreatic tumors. Int J Oncol 24: 107-113, 2004.
APA
Yamasaki, H., Ikeda, S., Okajima, M., Miura, Y., Asahara, T., Kohno, N., & Shimamoto, F. (2004). Expression and localization of MUC1, MUC2, MUC5AC and small intestinal mucin antigen in pancreatic tumors. International Journal of Oncology, 24, 107-113. https://doi.org/10.3892/ijo.24.1.107
MLA
Yamasaki, H., Ikeda, S., Okajima, M., Miura, Y., Asahara, T., Kohno, N., Shimamoto, F."Expression and localization of MUC1, MUC2, MUC5AC and small intestinal mucin antigen in pancreatic tumors". International Journal of Oncology 24.1 (2004): 107-113.
Chicago
Yamasaki, H., Ikeda, S., Okajima, M., Miura, Y., Asahara, T., Kohno, N., Shimamoto, F."Expression and localization of MUC1, MUC2, MUC5AC and small intestinal mucin antigen in pancreatic tumors". International Journal of Oncology 24, no. 1 (2004): 107-113. https://doi.org/10.3892/ijo.24.1.107
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