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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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February 2004 Volume 24 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2004 Volume 24 Issue 2

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Article

Characterization of p53 gene mutations in a Brazilian population with oral squamous cell carcinomas

  • Authors:
    • Anna C.M. Chaves
    • Karen Cherubini
    • Nilton Herter
    • Roque Furian
    • Diogenes S. Santos
    • Christopher Squier
    • Frederick E. Domann

  • View Affiliations / Copyright

    Affiliations: Faculdade de Odontologia, Brazil
  • Pages: 295-303
    |
    Published online on: February 1, 2004
       https://doi.org/10.3892/ijo.24.2.295
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Abstract

Mutations in the p53 tumor suppressor gene are present in approximately 50% of all human cancers. We sought to determine the frequency and type of p53 mutations in squamous cell carcinomas (SCC) of the oral cavity in a Brazilian population. To identify p53 mutations we used PCR-SSCP in tumor tissue microdissected from paraffin- embedded and from fresh-frozen sections followed by direct sequencing of SSCP bands with altered electrophoretic mobility. We identified p53 mutations in 40% of the human SCC analyzed. The mutations were of a broad spectrum, with a preponderance of G↷A and A↷G transitions with an apparent hotspot at the CpG dinucleotide at codon 290. Patient samples were stratified according to tobacco and alcohol consumption as well as by anatomic location of the tumor, and although trends did emerge, no statistically significant associations were obtained between the occurance of TP53 mutations and these lifestyle habits. We conclude that p53 mutations are common among oral cavity cancers in this population, and stress the significance of this study since it is the first analysis of p53 mutation in oral cancer in a southern Brazilian population.

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Copy and paste a formatted citation
Spandidos Publications style
Chaves AC, Cherubini K, Herter N, Furian R, Santos DS, Squier C and Domann FE: Characterization of p53 gene mutations in a Brazilian population with oral squamous cell carcinomas. Int J Oncol 24: 295-303, 2004.
APA
Chaves, A.C., Cherubini, K., Herter, N., Furian, R., Santos, D.S., Squier, C., & Domann, F.E. (2004). Characterization of p53 gene mutations in a Brazilian population with oral squamous cell carcinomas. International Journal of Oncology, 24, 295-303. https://doi.org/10.3892/ijo.24.2.295
MLA
Chaves, A. C., Cherubini, K., Herter, N., Furian, R., Santos, D. S., Squier, C., Domann, F. E."Characterization of p53 gene mutations in a Brazilian population with oral squamous cell carcinomas". International Journal of Oncology 24.2 (2004): 295-303.
Chicago
Chaves, A. C., Cherubini, K., Herter, N., Furian, R., Santos, D. S., Squier, C., Domann, F. E."Characterization of p53 gene mutations in a Brazilian population with oral squamous cell carcinomas". International Journal of Oncology 24, no. 2 (2004): 295-303. https://doi.org/10.3892/ijo.24.2.295
Copy and paste a formatted citation
x
Spandidos Publications style
Chaves AC, Cherubini K, Herter N, Furian R, Santos DS, Squier C and Domann FE: Characterization of p53 gene mutations in a Brazilian population with oral squamous cell carcinomas. Int J Oncol 24: 295-303, 2004.
APA
Chaves, A.C., Cherubini, K., Herter, N., Furian, R., Santos, D.S., Squier, C., & Domann, F.E. (2004). Characterization of p53 gene mutations in a Brazilian population with oral squamous cell carcinomas. International Journal of Oncology, 24, 295-303. https://doi.org/10.3892/ijo.24.2.295
MLA
Chaves, A. C., Cherubini, K., Herter, N., Furian, R., Santos, D. S., Squier, C., Domann, F. E."Characterization of p53 gene mutations in a Brazilian population with oral squamous cell carcinomas". International Journal of Oncology 24.2 (2004): 295-303.
Chicago
Chaves, A. C., Cherubini, K., Herter, N., Furian, R., Santos, D. S., Squier, C., Domann, F. E."Characterization of p53 gene mutations in a Brazilian population with oral squamous cell carcinomas". International Journal of Oncology 24, no. 2 (2004): 295-303. https://doi.org/10.3892/ijo.24.2.295
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