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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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March 2004 Volume 24 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 2004 Volume 24 Issue 3

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Article

Modulation of Matrix metalloproteinase-1 in nasopharyngeal cancer cells by photoactivation of hypericin

  • Authors:
    • Hongyan Du
    • Malini Olivo
    • Ratha Mahendran
    • Boon-Huat Bay

  • View Affiliations / Copyright

    Affiliations: Department of Anatomy, National University of Singapore, S117 597, Singapore
  • Pages: 657-662
    |
    Published online on: March 1, 2004
       https://doi.org/10.3892/ijo.24.3.657
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Abstract

Singlet oxygen (1O2) generated by ultraviolet A irradiation has been reported to induce cytokine-dependent Matrix metalloproteinase-1 (MMP-1) expression in dermal fibroblasts. In the present study, we analyzed the effect of hypericin-based photodynamic therapy (PDT) on MMP-1 expression in two nasopharyngeal cancer (NPC) cell lines and an animal tumor model. MMP-1 protein and mRNA expression were evaluated by Western blot analysis and quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR) respectively. Photoactivation of hypericin, a polycyclic phenanthroperylenedione, elicited an increase in MMP-1 protein and mRNA expression in well differentiated HK1 and poorly differentiated CNE-2 NPC cells in vitro. Similarly, there was up-regulation of MMP1 mRNA expression in hypericin-PDT-treated NPC/HK1-tumors. To our knowledge, this is the first time that modulation of MMP-1 expression has been demonstrated as a photodynamic effect of hypericin in NPC cells. This has clinical implications as MMP-1 is known to play an essential role in the biological process of matrix remodeling.

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Copy and paste a formatted citation
Spandidos Publications style
Du H, Olivo M, Mahendran R and Bay B: Modulation of Matrix metalloproteinase-1 in nasopharyngeal cancer cells by photoactivation of hypericin. Int J Oncol 24: 657-662, 2004.
APA
Du, H., Olivo, M., Mahendran, R., & Bay, B. (2004). Modulation of Matrix metalloproteinase-1 in nasopharyngeal cancer cells by photoactivation of hypericin. International Journal of Oncology, 24, 657-662. https://doi.org/10.3892/ijo.24.3.657
MLA
Du, H., Olivo, M., Mahendran, R., Bay, B."Modulation of Matrix metalloproteinase-1 in nasopharyngeal cancer cells by photoactivation of hypericin". International Journal of Oncology 24.3 (2004): 657-662.
Chicago
Du, H., Olivo, M., Mahendran, R., Bay, B."Modulation of Matrix metalloproteinase-1 in nasopharyngeal cancer cells by photoactivation of hypericin". International Journal of Oncology 24, no. 3 (2004): 657-662. https://doi.org/10.3892/ijo.24.3.657
Copy and paste a formatted citation
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Spandidos Publications style
Du H, Olivo M, Mahendran R and Bay B: Modulation of Matrix metalloproteinase-1 in nasopharyngeal cancer cells by photoactivation of hypericin. Int J Oncol 24: 657-662, 2004.
APA
Du, H., Olivo, M., Mahendran, R., & Bay, B. (2004). Modulation of Matrix metalloproteinase-1 in nasopharyngeal cancer cells by photoactivation of hypericin. International Journal of Oncology, 24, 657-662. https://doi.org/10.3892/ijo.24.3.657
MLA
Du, H., Olivo, M., Mahendran, R., Bay, B."Modulation of Matrix metalloproteinase-1 in nasopharyngeal cancer cells by photoactivation of hypericin". International Journal of Oncology 24.3 (2004): 657-662.
Chicago
Du, H., Olivo, M., Mahendran, R., Bay, B."Modulation of Matrix metalloproteinase-1 in nasopharyngeal cancer cells by photoactivation of hypericin". International Journal of Oncology 24, no. 3 (2004): 657-662. https://doi.org/10.3892/ijo.24.3.657
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