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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 2004 Volume 25 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2004 Volume 25 Issue 1

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Article

Interleukin-1β and tumour necrosis factor-α promote the transformation of human immortalised mesothelial cells by erionite

  • Authors:
    • Yaohe Wang
    • Steven P. Faux
    • Gunnel Hallden
    • David H. Kirn
    • Cathy E. Houghton
    • Nicholas R. Lemoine
    • Graham Patrick

  • View Affiliations / Copyright

    Affiliations: Molecular Oncology Unit, Cancer Research UK, Imperial College London Hammersmith Hospital, London W12 0NN, UK. yaohe.wang@cancer.org.uk
  • Pages: 173-178
    |
    Published online on: July 1, 2004
       https://doi.org/10.3892/ijo.25.1.173
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Abstract

Asbestos fails to induce the transformation of human mesothelial cells in vitro although it has been known as a potential carcinogen to human mesothelial cells. Interleukin-1β (IL-1β) and tumour necrosis factor-α (TNF-α) are major cytokines released by macrophages after inhalation of asbestos. These cytokines can regulate mesothelial cell proliferation both in vitro and in vivo. In the present study, we used the growth in soft agar as an index of transformation and investigated the role of IL-1β and TNF-α during the process of human mesothelial cell carcinogenesis. Both IL-1β and TNF-α were demonstrated to enhance erionite-induced transformation of the immortalised, non-tumorigenic human mesothelial cell line (MeT-5A) in vitro. The MeT-5A cells could only be transformed when the cells were exposed to a combination of cytokines and erionite, or at least two cytokines together without erionite, for at least 4 months in vitro. The findings presented here suggest that IL-1β and TNF-α play a significant role in the pathogenesis of mesothelioma, and that it might be desirable to block or inhibit cytokine secretion in high risk populations to prevent mesothelioma.

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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Faux SP, Hallden G, Kirn DH, Houghton CE, Lemoine NR and Patrick G: Interleukin-1β and tumour necrosis factor-α promote the transformation of human immortalised mesothelial cells by erionite. Int J Oncol 25: 173-178, 2004.
APA
Wang, Y., Faux, S.P., Hallden, G., Kirn, D.H., Houghton, C.E., Lemoine, N.R., & Patrick, G. (2004). Interleukin-1β and tumour necrosis factor-α promote the transformation of human immortalised mesothelial cells by erionite. International Journal of Oncology, 25, 173-178. https://doi.org/10.3892/ijo.25.1.173
MLA
Wang, Y., Faux, S. P., Hallden, G., Kirn, D. H., Houghton, C. E., Lemoine, N. R., Patrick, G."Interleukin-1β and tumour necrosis factor-α promote the transformation of human immortalised mesothelial cells by erionite". International Journal of Oncology 25.1 (2004): 173-178.
Chicago
Wang, Y., Faux, S. P., Hallden, G., Kirn, D. H., Houghton, C. E., Lemoine, N. R., Patrick, G."Interleukin-1β and tumour necrosis factor-α promote the transformation of human immortalised mesothelial cells by erionite". International Journal of Oncology 25, no. 1 (2004): 173-178. https://doi.org/10.3892/ijo.25.1.173
Copy and paste a formatted citation
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Spandidos Publications style
Wang Y, Faux SP, Hallden G, Kirn DH, Houghton CE, Lemoine NR and Patrick G: Interleukin-1β and tumour necrosis factor-α promote the transformation of human immortalised mesothelial cells by erionite. Int J Oncol 25: 173-178, 2004.
APA
Wang, Y., Faux, S.P., Hallden, G., Kirn, D.H., Houghton, C.E., Lemoine, N.R., & Patrick, G. (2004). Interleukin-1β and tumour necrosis factor-α promote the transformation of human immortalised mesothelial cells by erionite. International Journal of Oncology, 25, 173-178. https://doi.org/10.3892/ijo.25.1.173
MLA
Wang, Y., Faux, S. P., Hallden, G., Kirn, D. H., Houghton, C. E., Lemoine, N. R., Patrick, G."Interleukin-1β and tumour necrosis factor-α promote the transformation of human immortalised mesothelial cells by erionite". International Journal of Oncology 25.1 (2004): 173-178.
Chicago
Wang, Y., Faux, S. P., Hallden, G., Kirn, D. H., Houghton, C. E., Lemoine, N. R., Patrick, G."Interleukin-1β and tumour necrosis factor-α promote the transformation of human immortalised mesothelial cells by erionite". International Journal of Oncology 25, no. 1 (2004): 173-178. https://doi.org/10.3892/ijo.25.1.173
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