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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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August 2004 Volume 25 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2004 Volume 25 Issue 2

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Article

Growth arrest and apoptosis in adult T cell leukemia cell lines following IL-2 deprivation

  • Authors:
    • Satoshi Fujimura
    • Fumiko Arakawa
    • Yasuaki Yamada
    • Shaoxi Liao
    • Pranay D. Khare
    • Masahide Kuroki
    • Junko Ono

  • View Affiliations / Copyright

    Affiliations: Department of Laboratory Medicine, Fukuoka University School of Medicine, Fukuoka 814-0180, Japan. fujimura@minf.med.fukuoka-u.ac.jp
  • Pages: 437-443
    |
    Published online on: August 1, 2004
       https://doi.org/10.3892/ijo.25.2.437
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Abstract

Adult T-cell leukemia (ATL) is a peripheral T-cell neoplasm caused by human T-cell leukemia virus type-I (HTLV-I). Since ATL cells often require IL-2 for their proliferation and survival, we examined the effect of IL-2 deprivation on the IL-2-dependent ATL cells established from ATL patients. After IL-2 withdrawal, these cells were arrested in the G1 phase and then underwent apoptosis. p27Kip1 was observed to act as a cell cycle inhibitor. A decrease in the amount of Bcl-xL was more distinct than that of Bcl-2, while Bax increased slightly during IL-2 withdrawal. The activation of caspase-3 and the loss of mitochondrial membrane potential were also observed. An overexpression of Bcl-xL protein in the KK1, one of the ATL cell lines, suppressed apoptosis by the 3rd day, however, apoptosis could not be prevented completely. Thereafter, a decrease in Bcl-xL and an activation of caspase-3 were observed even under the overexpression of Bcl-xL. The mitochondrial membrane potential and the intra-cellular levels of reactive oxygen species (ROS) also changed due to IL-2 deprivation. From these results, the IL-2 signals are considered to be essential for the survival of ATL cells, and the interruption of IL-2 signaling might thus be useful as a potentially new treatment for ATL.

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Copy and paste a formatted citation
Spandidos Publications style
Fujimura S, Arakawa F, Yamada Y, Liao S, Khare PD, Kuroki M and Ono J: Growth arrest and apoptosis in adult T cell leukemia cell lines following IL-2 deprivation. Int J Oncol 25: 437-443, 2004.
APA
Fujimura, S., Arakawa, F., Yamada, Y., Liao, S., Khare, P.D., Kuroki, M., & Ono, J. (2004). Growth arrest and apoptosis in adult T cell leukemia cell lines following IL-2 deprivation. International Journal of Oncology, 25, 437-443. https://doi.org/10.3892/ijo.25.2.437
MLA
Fujimura, S., Arakawa, F., Yamada, Y., Liao, S., Khare, P. D., Kuroki, M., Ono, J."Growth arrest and apoptosis in adult T cell leukemia cell lines following IL-2 deprivation". International Journal of Oncology 25.2 (2004): 437-443.
Chicago
Fujimura, S., Arakawa, F., Yamada, Y., Liao, S., Khare, P. D., Kuroki, M., Ono, J."Growth arrest and apoptosis in adult T cell leukemia cell lines following IL-2 deprivation". International Journal of Oncology 25, no. 2 (2004): 437-443. https://doi.org/10.3892/ijo.25.2.437
Copy and paste a formatted citation
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Spandidos Publications style
Fujimura S, Arakawa F, Yamada Y, Liao S, Khare PD, Kuroki M and Ono J: Growth arrest and apoptosis in adult T cell leukemia cell lines following IL-2 deprivation. Int J Oncol 25: 437-443, 2004.
APA
Fujimura, S., Arakawa, F., Yamada, Y., Liao, S., Khare, P.D., Kuroki, M., & Ono, J. (2004). Growth arrest and apoptosis in adult T cell leukemia cell lines following IL-2 deprivation. International Journal of Oncology, 25, 437-443. https://doi.org/10.3892/ijo.25.2.437
MLA
Fujimura, S., Arakawa, F., Yamada, Y., Liao, S., Khare, P. D., Kuroki, M., Ono, J."Growth arrest and apoptosis in adult T cell leukemia cell lines following IL-2 deprivation". International Journal of Oncology 25.2 (2004): 437-443.
Chicago
Fujimura, S., Arakawa, F., Yamada, Y., Liao, S., Khare, P. D., Kuroki, M., Ono, J."Growth arrest and apoptosis in adult T cell leukemia cell lines following IL-2 deprivation". International Journal of Oncology 25, no. 2 (2004): 437-443. https://doi.org/10.3892/ijo.25.2.437
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