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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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August 2004 Volume 25 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2004 Volume 25 Issue 2

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Article

Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer

  • Authors:
    • Yoshio Hosoi
    • Toshiaki Watanabe
    • Keiichi Nakagawa
    • Yoshihisa Matsumoto
    • Atsushi Enomoto
    • Akinori Morita
    • Hirokazu Nagawa
    • Norio Suzuki

  • View Affiliations / Copyright

    Affiliations: Department of Radiation Research, Faculty of Medicine, University of Tokyo, Tokyo 113-0033, Japan. hosoi@m.u-tokyo.ac.jp
  • Pages: 461-468
    |
    Published online on: August 1, 2004
       https://doi.org/10.3892/ijo.25.2.461
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Abstract

Tumor tissues and adjacent normal tissues in 12 colorectal cancers were examined for quantitative differences in: i) activity of DNA-dependent protein kinase (DNA-PK), which functions in DNA double-strand breads repair, and ii) protein and mRNA levels of Ku70, Ku80, DNA-PKcs and transcriptional factor Sp1. DNA-PK activity and protein/mRNA levels of Ku70, Ku80, DNA-PKcs and Sp1 were significantly higher in the tumor tissues compared with the normal tissues. Significant correlations between DNA-PK activity and protein/mRNA levels of Ku70, Ku80, DNA-PKcs and Sp1 were observed. Because Ku80 and DNA-PKcs have consensus Sp1 recognition elements in their promoter region, the DNA sequence of Ku70 promoter region was analyzed. Analysis of Ku70 promoter region reveled that Ku70 gene has consensus Sp1 recognition elements in its promoter region. mRNA levels of Ku70, Ku80 and DNA-PKcs were correlated with one another, and significant correlations between Sp1 protein level and mRNA levels of Ku70 and Ku80 were observed. These results suggest that DNA-PK activity and protein- and mRNA-levels of Ku70, Ku80 and DNA-PKcs were elevated in tumor tissues in patients with colorectal cancer because of elevated Sp1 protein levels in tumor tissues.

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Copy and paste a formatted citation
Spandidos Publications style
Hosoi Y, Watanabe T, Nakagawa K, Matsumoto Y, Enomoto A, Morita A, Nagawa H and Suzuki N: Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer. Int J Oncol 25: 461-468, 2004.
APA
Hosoi, Y., Watanabe, T., Nakagawa, K., Matsumoto, Y., Enomoto, A., Morita, A. ... Suzuki, N. (2004). Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer. International Journal of Oncology, 25, 461-468. https://doi.org/10.3892/ijo.25.2.461
MLA
Hosoi, Y., Watanabe, T., Nakagawa, K., Matsumoto, Y., Enomoto, A., Morita, A., Nagawa, H., Suzuki, N."Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer". International Journal of Oncology 25.2 (2004): 461-468.
Chicago
Hosoi, Y., Watanabe, T., Nakagawa, K., Matsumoto, Y., Enomoto, A., Morita, A., Nagawa, H., Suzuki, N."Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer". International Journal of Oncology 25, no. 2 (2004): 461-468. https://doi.org/10.3892/ijo.25.2.461
Copy and paste a formatted citation
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Spandidos Publications style
Hosoi Y, Watanabe T, Nakagawa K, Matsumoto Y, Enomoto A, Morita A, Nagawa H and Suzuki N: Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer. Int J Oncol 25: 461-468, 2004.
APA
Hosoi, Y., Watanabe, T., Nakagawa, K., Matsumoto, Y., Enomoto, A., Morita, A. ... Suzuki, N. (2004). Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer. International Journal of Oncology, 25, 461-468. https://doi.org/10.3892/ijo.25.2.461
MLA
Hosoi, Y., Watanabe, T., Nakagawa, K., Matsumoto, Y., Enomoto, A., Morita, A., Nagawa, H., Suzuki, N."Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer". International Journal of Oncology 25.2 (2004): 461-468.
Chicago
Hosoi, Y., Watanabe, T., Nakagawa, K., Matsumoto, Y., Enomoto, A., Morita, A., Nagawa, H., Suzuki, N."Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer". International Journal of Oncology 25, no. 2 (2004): 461-468. https://doi.org/10.3892/ijo.25.2.461
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