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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2004 Volume 25 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2004 Volume 25 Issue 6

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Article

MAP kinase pathways involved in glioblastoma response to erucylphosphocholine

  • Authors:
    • Wilfried Kugler
    • Bernhard Erdlenbruch
    • Karoline Otten
    • Verena Jendrossek
    • Hansjörg Eibl
    • Max Lakomek

  • View Affiliations / Copyright

    Affiliations: Universitäts-Kinderklinik, D-37099 Göttingen, Germany. wkugler@med.uni-goettingen.de
  • Pages: 1721-1727
    |
    Published online on: December 1, 2004
       https://doi.org/10.3892/ijo.25.6.1721
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Abstract

Erucylphosphocholine (ErPC) is a promising antineoplastic drug for the treatment of malignant brain tumors. It exerts strong anticancer activity and induces apoptosis even in chemoresistant glioma cells. In the present study, A172 and U373MG glioma cells were treated with ErPC to explore the contribution of MAP kinase family members ERK, JNK and p38 kinase to ErPC-induced cell death. The exposure to ErPC led to activation of JNK and concurrent inhibition of ERK in both cell lines. Using specific MAP kinase inhibitors we confirmed that in U373MG cells ERK was blocked and JNK was activated upon ErPC treatment. Both effects were dependent on caspase activation. In A172 cells, ErPC treatment resulted in an activation of the JNK pathway, whereas the situation with respect to ERK signalling was more complex. We conclude that inhibition of the ERK pathway by ErPC may be related to antiproliferative effects, while activation of the JNK pathway may be responsible for its pro-apoptotic action.

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Copy and paste a formatted citation
Spandidos Publications style
Kugler W, Erdlenbruch B, Otten K, Jendrossek V, Eibl H and Lakomek M: MAP kinase pathways involved in glioblastoma response to erucylphosphocholine. Int J Oncol 25: 1721-1727, 2004.
APA
Kugler, W., Erdlenbruch, B., Otten, K., Jendrossek, V., Eibl, H., & Lakomek, M. (2004). MAP kinase pathways involved in glioblastoma response to erucylphosphocholine. International Journal of Oncology, 25, 1721-1727. https://doi.org/10.3892/ijo.25.6.1721
MLA
Kugler, W., Erdlenbruch, B., Otten, K., Jendrossek, V., Eibl, H., Lakomek, M."MAP kinase pathways involved in glioblastoma response to erucylphosphocholine". International Journal of Oncology 25.6 (2004): 1721-1727.
Chicago
Kugler, W., Erdlenbruch, B., Otten, K., Jendrossek, V., Eibl, H., Lakomek, M."MAP kinase pathways involved in glioblastoma response to erucylphosphocholine". International Journal of Oncology 25, no. 6 (2004): 1721-1727. https://doi.org/10.3892/ijo.25.6.1721
Copy and paste a formatted citation
x
Spandidos Publications style
Kugler W, Erdlenbruch B, Otten K, Jendrossek V, Eibl H and Lakomek M: MAP kinase pathways involved in glioblastoma response to erucylphosphocholine. Int J Oncol 25: 1721-1727, 2004.
APA
Kugler, W., Erdlenbruch, B., Otten, K., Jendrossek, V., Eibl, H., & Lakomek, M. (2004). MAP kinase pathways involved in glioblastoma response to erucylphosphocholine. International Journal of Oncology, 25, 1721-1727. https://doi.org/10.3892/ijo.25.6.1721
MLA
Kugler, W., Erdlenbruch, B., Otten, K., Jendrossek, V., Eibl, H., Lakomek, M."MAP kinase pathways involved in glioblastoma response to erucylphosphocholine". International Journal of Oncology 25.6 (2004): 1721-1727.
Chicago
Kugler, W., Erdlenbruch, B., Otten, K., Jendrossek, V., Eibl, H., Lakomek, M."MAP kinase pathways involved in glioblastoma response to erucylphosphocholine". International Journal of Oncology 25, no. 6 (2004): 1721-1727. https://doi.org/10.3892/ijo.25.6.1721
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