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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2004 Volume 25 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2004 Volume 25 Issue 6

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Article

The BRAFT1796A transversion is a prevalent mutational event in human thyroid microcarcinoma

  • Authors:
    • Ilya Sedliarou
    • Vladimir Saenko
    • Dmitry Lantsov
    • Tatiana Rogounovitch
    • Hiroyuki Namba
    • Aleksandr Abrosimov
    • Eugeny Lushnikov
    • Atsushi Kumagai
    • Masahiro Nakashima
    • Serik Meirmanov
    • Mariko Mine
    • Tomayoshi Hayashi
    • Shunichi Yamashita
  • View Affiliations / Copyright

    Affiliations: Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan
  • Pages: 1729-1735
    |
    Published online on: December 1, 2004
       https://doi.org/10.3892/ijo.25.6.1729
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Abstract

Mutation in exon 15 of the BRAF gene is a characteristic feature of human thyroid papillary carcinoma (PTC). To determine the role of such mutation(s) in the neoplastic progression of thyroid papillary microcarcinoma (PMC), we analyzed 46 cases from 31 Russian and 15 Japanese patients with PMC. Mutated BRAF (the BRAFT1796A transversion in all cases) was detected in 13/46 (28.2%) of the tumors: 9/31 (29.0%) and 4/15 (26.6%) in Russian and Japanese individuals, respectively, displaying no signs of difference in the mutational rates in the PMCs from patients with diverse genetic background seen in PTCs. Occurrence of the BRAF mutation did not significantly correlate with the patients' gender, age at presentation, metastatic indices or with papillary, mixed papillary and follicular, and solid/trabecular PMC histotype. On the contrary, the tumors of follicular morphology significantly associated with the mutation-free genotype (P=0.018), and in the mixed-type tumors characterized by co-occurrence of well-differentiated and less differentiated components, the BRAF mutational frequency was significantly elevated (P=0.020). The results indicate the BRAFT1796A mutation is prevalent in PMCs, and thus these tumors may have a spectrum of genetic events partly overlapping with that of PTCs.

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Copy and paste a formatted citation
Spandidos Publications style
Sedliarou I, Saenko V, Lantsov D, Rogounovitch T, Namba H, Abrosimov A, Lushnikov E, Kumagai A, Nakashima M, Meirmanov S, Meirmanov S, et al: The BRAFT1796A transversion is a prevalent mutational event in human thyroid microcarcinoma. Int J Oncol 25: 1729-1735, 2004.
APA
Sedliarou, I., Saenko, V., Lantsov, D., Rogounovitch, T., Namba, H., Abrosimov, A. ... Yamashita, S. (2004). The BRAFT1796A transversion is a prevalent mutational event in human thyroid microcarcinoma. International Journal of Oncology, 25, 1729-1735. https://doi.org/10.3892/ijo.25.6.1729
MLA
Sedliarou, I., Saenko, V., Lantsov, D., Rogounovitch, T., Namba, H., Abrosimov, A., Lushnikov, E., Kumagai, A., Nakashima, M., Meirmanov, S., Mine, M., Hayashi, T., Yamashita, S."The BRAFT1796A transversion is a prevalent mutational event in human thyroid microcarcinoma". International Journal of Oncology 25.6 (2004): 1729-1735.
Chicago
Sedliarou, I., Saenko, V., Lantsov, D., Rogounovitch, T., Namba, H., Abrosimov, A., Lushnikov, E., Kumagai, A., Nakashima, M., Meirmanov, S., Mine, M., Hayashi, T., Yamashita, S."The BRAFT1796A transversion is a prevalent mutational event in human thyroid microcarcinoma". International Journal of Oncology 25, no. 6 (2004): 1729-1735. https://doi.org/10.3892/ijo.25.6.1729
Copy and paste a formatted citation
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Spandidos Publications style
Sedliarou I, Saenko V, Lantsov D, Rogounovitch T, Namba H, Abrosimov A, Lushnikov E, Kumagai A, Nakashima M, Meirmanov S, Meirmanov S, et al: The BRAFT1796A transversion is a prevalent mutational event in human thyroid microcarcinoma. Int J Oncol 25: 1729-1735, 2004.
APA
Sedliarou, I., Saenko, V., Lantsov, D., Rogounovitch, T., Namba, H., Abrosimov, A. ... Yamashita, S. (2004). The BRAFT1796A transversion is a prevalent mutational event in human thyroid microcarcinoma. International Journal of Oncology, 25, 1729-1735. https://doi.org/10.3892/ijo.25.6.1729
MLA
Sedliarou, I., Saenko, V., Lantsov, D., Rogounovitch, T., Namba, H., Abrosimov, A., Lushnikov, E., Kumagai, A., Nakashima, M., Meirmanov, S., Mine, M., Hayashi, T., Yamashita, S."The BRAFT1796A transversion is a prevalent mutational event in human thyroid microcarcinoma". International Journal of Oncology 25.6 (2004): 1729-1735.
Chicago
Sedliarou, I., Saenko, V., Lantsov, D., Rogounovitch, T., Namba, H., Abrosimov, A., Lushnikov, E., Kumagai, A., Nakashima, M., Meirmanov, S., Mine, M., Hayashi, T., Yamashita, S."The BRAFT1796A transversion is a prevalent mutational event in human thyroid microcarcinoma". International Journal of Oncology 25, no. 6 (2004): 1729-1735. https://doi.org/10.3892/ijo.25.6.1729
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