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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2004 Volume 25 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2004 Volume 25 Issue 6

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Article

Overexpression and amplification of STK15 in human gliomas

  • Authors:
    • Alexandra Klein
    • Wilfried Reichardt
    • Volker Jung
    • Klaus D. Zang
    • Eckart Meese
    • Steffi Urbschat

  • View Affiliations / Copyright

    Affiliations: Institute of Human Genetics, Saarland University, D-66421 Homburg/Saar, Germany
  • Pages: 1789-1794
    |
    Published online on: December 1, 2004
       https://doi.org/10.3892/ijo.25.6.1789
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Abstract

The serine/threonine kinase 15 (STK15) at chromosome 20q13.2 is frequently shown to be amplified and overexpressed in several human cancers. STK15 has been reported to act as a cell cycle regulator and its overexpression induces centrosome amplification and aneuploidy. Recently we showed that STK15 even plays a role in human malignant brain tumours and we described an amplification of the gene in 31% of the investigated gliomas. In this study we scrutinized the correlation of increased STK15 on DNA and mRNA levels in gliomas of different histological grades. Southern blotting confirmed the amplification frequency of the STK15 gene, which had been previously detected by comparative PCR. In total, DNA gains were found in 26% of the investigated gliomas. Interestingly, we detected overexpression of STK15 mRNA in 60% of the analyzed brain tumours. The elevated expression does not strongly correlate with gains on DNA level, but all cases with an amplification of the STK15 gene display overexpression. Gains of the STK15 gene seem to occur irrespectively of the histological grades of the tumours, so that STK15 probably is not a progression associated factor. Amplification and overexpression of the kinase rather represent a primary alteration in human gliomas, which could play an important role as an early event in all glioma subtypes.

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Copy and paste a formatted citation
Spandidos Publications style
Klein A, Reichardt W, Jung V, Zang KD, Meese E and Urbschat S: Overexpression and amplification of STK15 in human gliomas. Int J Oncol 25: 1789-1794, 2004.
APA
Klein, A., Reichardt, W., Jung, V., Zang, K.D., Meese, E., & Urbschat, S. (2004). Overexpression and amplification of STK15 in human gliomas. International Journal of Oncology, 25, 1789-1794. https://doi.org/10.3892/ijo.25.6.1789
MLA
Klein, A., Reichardt, W., Jung, V., Zang, K. D., Meese, E., Urbschat, S."Overexpression and amplification of STK15 in human gliomas". International Journal of Oncology 25.6 (2004): 1789-1794.
Chicago
Klein, A., Reichardt, W., Jung, V., Zang, K. D., Meese, E., Urbschat, S."Overexpression and amplification of STK15 in human gliomas". International Journal of Oncology 25, no. 6 (2004): 1789-1794. https://doi.org/10.3892/ijo.25.6.1789
Copy and paste a formatted citation
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Spandidos Publications style
Klein A, Reichardt W, Jung V, Zang KD, Meese E and Urbschat S: Overexpression and amplification of STK15 in human gliomas. Int J Oncol 25: 1789-1794, 2004.
APA
Klein, A., Reichardt, W., Jung, V., Zang, K.D., Meese, E., & Urbschat, S. (2004). Overexpression and amplification of STK15 in human gliomas. International Journal of Oncology, 25, 1789-1794. https://doi.org/10.3892/ijo.25.6.1789
MLA
Klein, A., Reichardt, W., Jung, V., Zang, K. D., Meese, E., Urbschat, S."Overexpression and amplification of STK15 in human gliomas". International Journal of Oncology 25.6 (2004): 1789-1794.
Chicago
Klein, A., Reichardt, W., Jung, V., Zang, K. D., Meese, E., Urbschat, S."Overexpression and amplification of STK15 in human gliomas". International Journal of Oncology 25, no. 6 (2004): 1789-1794. https://doi.org/10.3892/ijo.25.6.1789
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