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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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January 2005 Volume 26 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2005 Volume 26 Issue 1

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Article

Characterization of chromosome 3q and 12q amplicons in nasopharyngeal carcinoma cell lines

  • Authors:
    • Yan-Yan Or
    • Angela Bik-Yu Hui
    • Ka-Ying Tam
    • Dolly P. Huang
    • Kwok-Wai Lo

  • View Affiliations / Copyright

    Affiliations: Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong, P.R. China
  • Pages: 49-56
    |
    Published online on: January 1, 2005
       https://doi.org/10.3892/ijo.26.1.49
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Abstract

Nasopharyngeal carcinoma (NPC) is a distinct geographical disease with high incidence in Southeast Asia. Previous CGH studies have located multiple regions of chromosomal gains and losses in NPC. To elucidate the regions of gain and amplification, a high-resolution array comparative genomic hybridization (array CGH) was applied to characterize the common amplicons in NPC cell lines and xenografts. Consistent with our previous CGH findings, frequent gains at chromosomes 1q, 3q, 7, 8, 9q, 12q and 20q were detected. High incidence of gains were identified on chromosome 3q and 12q. The findings were further confirmed by FISH analysis. Using 16 BAC clones on 3q26-28 and 6 BAC clones on 12q13, the smallest regions of gain at 3q and 12q were defined on five NPC cell lines. Chromosome 3q26.33 (RP11-510K16) and 12q13.2-q13.3 (RP11-183H16) showed the highest amplification frequency in FISH analysis with 100 and 66.7%, respectively. PIK3CA, a candidate oncogene located at 3q26.32 adjacent to this 3q amplicon was investigated by real-time quantitative reverse transcriptase-polymerase chain reaction (RT-PCR). Overexpression of this gene was found in 4 NPC cell lines and 3 xenografts. The findings implied that PIK3CA may be a putative oncogene involved in the tumorigenesis of NPC.

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Copy and paste a formatted citation
Spandidos Publications style
Or Y, Hui AB, Tam K, Huang DP and Lo K: Characterization of chromosome 3q and 12q amplicons in nasopharyngeal carcinoma cell lines. Int J Oncol 26: 49-56, 2005.
APA
Or, Y., Hui, A.B., Tam, K., Huang, D.P., & Lo, K. (2005). Characterization of chromosome 3q and 12q amplicons in nasopharyngeal carcinoma cell lines. International Journal of Oncology, 26, 49-56. https://doi.org/10.3892/ijo.26.1.49
MLA
Or, Y., Hui, A. B., Tam, K., Huang, D. P., Lo, K."Characterization of chromosome 3q and 12q amplicons in nasopharyngeal carcinoma cell lines". International Journal of Oncology 26.1 (2005): 49-56.
Chicago
Or, Y., Hui, A. B., Tam, K., Huang, D. P., Lo, K."Characterization of chromosome 3q and 12q amplicons in nasopharyngeal carcinoma cell lines". International Journal of Oncology 26, no. 1 (2005): 49-56. https://doi.org/10.3892/ijo.26.1.49
Copy and paste a formatted citation
x
Spandidos Publications style
Or Y, Hui AB, Tam K, Huang DP and Lo K: Characterization of chromosome 3q and 12q amplicons in nasopharyngeal carcinoma cell lines. Int J Oncol 26: 49-56, 2005.
APA
Or, Y., Hui, A.B., Tam, K., Huang, D.P., & Lo, K. (2005). Characterization of chromosome 3q and 12q amplicons in nasopharyngeal carcinoma cell lines. International Journal of Oncology, 26, 49-56. https://doi.org/10.3892/ijo.26.1.49
MLA
Or, Y., Hui, A. B., Tam, K., Huang, D. P., Lo, K."Characterization of chromosome 3q and 12q amplicons in nasopharyngeal carcinoma cell lines". International Journal of Oncology 26.1 (2005): 49-56.
Chicago
Or, Y., Hui, A. B., Tam, K., Huang, D. P., Lo, K."Characterization of chromosome 3q and 12q amplicons in nasopharyngeal carcinoma cell lines". International Journal of Oncology 26, no. 1 (2005): 49-56. https://doi.org/10.3892/ijo.26.1.49
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